Review
Biochemistry & Molecular Biology
Walia Zahra, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Priyanka Kumari Keshri, Priyanka Gautam, Surya Pratap Singh
Summary: This article discusses the medicinal importance of Mucuna pruriens in the treatment of neurological disorders such as Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis, and stroke. Mucuna pruriens is known for its anti-oxidative and anti-inflammatory properties and has been widely used in Ayurveda.
NEUROCHEMICAL RESEARCH
(2022)
Article
Plant Sciences
Sitthichai Iamsaard, Somboon Kietinun, Jintana Sattayasai, Kingkan Bunluepuech, Alexander Tsang-Hsien Wu, Pannawat Choowong-In
Summary: This study investigates the preventive effects of Thai Mucuna pruriens (T-MP) seed extract against seminal vesicle damage, apoptotic and Nrf2 protein expression in mice under chronic unpredictable mild stress (CUMS). The results show that T-MP extract can improve seminal epithelial damage and secretion of fluid containing essential substances and proteins in CUMS mice, increase the expression of AR and TyrPho proteins, inhibit seminal vesicular apoptosis through the suppression of Hsp70 and caspase expression, and increase Nrf2 expression. This study demonstrates that T-MP seeds have antiapoptotic properties and can be used to enhance seminal plasma quality.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Renata Leite Tavares, Maria Helena de Araujo Vasconcelos, Victor Augusto Mathias Dorand, Emanuel Ubaldino Torres Junior, Lydiane de Lima Tavares Toscano, Rubens Teixeira de Queiroz, Adriano Francisco Alves, Marciane Magnani, Omar Guzman-Quevedo, Jailane Aquino
Summary: The study found that obese rats treated with MP showed lower caloric intake and body weight, as well as improved fat, triglycerides, insulin, leptin, and other biochemical parameters, increased levels of HDL, and helped reverse changes in liver and adipose tissues caused by obesity, promoting intestinal health.
Article
Biochemistry & Molecular Biology
Sagar Seetharamaiah, Vidya Shimoga Muddappa, Manjunatha Bukkambudhi Krishnaswamy, Rashmi Kanugodu Vasappa
Summary: Mucuna pruriens (MP), a traditional plant used for treating Parkinson's disease and male fertility issues, has been found to have antioxidant and anticancer effects. In this study, methanolic seed extracts of two common varieties of MP were compared for their anticancer and antioxidant potentials, and Mucuna pruriens var. pruriens (MPP) showed the highest antioxidant potential and better apoptotic efficacy compared to Mucuna pruriens var. utilis (MPU). MPP also exhibited the highest apoptosis and cell cycle arrest, and upregulated p53 expression.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Nareelak Tangsrisakda, Therachon Kamollerd, Chayakorn Taoto, Sudtida Bunsueb, Chadaporn Chaimontri, Pannawat Choowong-In, Natthapol Lapyuneyong, Alexander Th Wu, Wipawee Thukhammee, Jintanaporn Wattanathorn, Supatcharee Arun, Tarinee Sawatpanich, Sitthichai Iamsaard
Summary: The study found that Mucuna pruriens seed extract can improve sexual behavior dysfunction in rats treated with ethanol and protect the reproductive system from damage. This may be achieved through improving the expression of testicular functional proteins.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Aungkana Rachsee, Natthakarn Chiranthanut, Phraepakaporn Kunnaja, Seewaboon Sireeratawong, Parirat Khonsung, Sunee Chansakaow, Ampai Panthong
Summary: Mucuna pruriens seed extract demonstrated significant anti-inflammatory effects in LPS-stimulated BV2 microglial cells by inhibiting the release of inflammatory mediators such as NO, IL-1 beta, IL-6, and TNF-alpha, and by suppressing the NF-kappa B signaling pathway. These findings suggest the potential use of M. pruriens seeds in traditional and alternative medicine for treating PD and other inflammation-associated diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Engineering, Chemical
Jordana Benfica, Eduarda S. Morais, Julia S. Miranda, Mara G. Freire, Rita de Cassia Superbi de Sousa, Joao A. P. Coutinho
Summary: By investigating different solvents and optimizing extraction conditions, citric acid aqueous solution was identified as an effective solvent for extracting levodopa from Mucuna pruriens seeds, achieving an extraction efficiency of 9.2%. Recovery of levodopa was successfully done using an ion exchange column, and the solvent was reusable for three extraction cycles without significant losses in efficiency.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Shravan D. Kumbhare, Sanghadeep S. Ukey, Dayanand P. Gogle
Summary: Globally, 15-24% of couples are unable to conceive naturally, and half of these cases are due to male infertility. Reactive oxygen species (ROS) have a negative impact on male fertility, and are involved in 80% of idiopathic male infertility cases. Medicinal plants are considered as an alternative approach for improving male infertility symptoms caused by ROS. Mucuna pruriens and Flemingia praecox are two plants that show potential for improving male fertility.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Jafar K. Lone, Mandapanda A. Lekha, Rajiv P. Bharadwaj, Fasil Ali, M. Arumugam Pillai, Shabir H. Wani, Jeshima Khan Yasin, K. S. Chandrashekharaiah
Summary: A Bowman-Birk protease, Mucuna pruriens trypsin inhibitor (MPTI), was purified from seeds, showing high stability and functional efficiency as a competitive inhibitor. Various analyses revealed the structural features and mechanisms underlying the potent anti-inflammatory activity of MPTI, confirming its belonging to the BBI family of inhibitors.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Yanca Araujo Frias, Edivaldo Wilson Lima, Munick Beato Aragao, Laura Silva Nantes, Bruno Rafael Almeida Moreira, Victor Hugo Cruz, Rafael Simoes Tomaz, Paulo Renato Matos Lopes
Summary: Pesticides are cost-effective solutions to control weeds, but they can become severe environmental pollutants when escaping into natural ecosystems. This study investigated whether Mucuna pruriens could be used as a phytoremediator for tebuthiuron in soil with vinasse. It was found that M. pruriens could not effectively remove tebuthiuron from the soil and the pesticide caused phytotoxicity, limiting its growth. The introduction of vinasse intensified the damage and decreased biomass production.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dong-Geun Han, Min-Jun Bae, Bong-Jeon An
Summary: This study verified the application of Mucuna pruriens extracts as a natural-based raw material with anti-inflammatory function. The extracts exhibited nitric oxide inhibition activity, with the extracts obtained using hot water and 70% ethanol showing the best activity. Western blot analysis confirmed the inhibitory effects of these extracts on inflammation-related proteins. Furthermore, high levels of L-DOPA were detected in the extracts. Therefore, Mucuna pruriens extracts have the potential to be used as anti-inflammatory materials.
Article
Plant Sciences
Natthapol Lapyuneyong, Nareelak Tangsrisakda, Pannawat Choowong-In, Kowit Chaisiwamongkol, Nongnut Uabundit, Tarinee Sawatpanich, Supatcharee Arun, Alexander Tsang-Hsien Wu, Sitthichai Iamsaard
Summary: The study found that seed extract of Thai Mucuna pruriens (L.) DC. var. pruriens could improve cortisol level, protect reproductive tissues and sperm parameters, and protect against adverse reproductive parameters in chronic stress through improvements of functionally testicular markers and reductions of apoptotic proteins.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chayarit Vilairat, Khwanlada Kobtrakul, Sornkanok Vimolmangkang
Summary: L-DOPA is an essential drug for treating Parkinson's disease, which can be synthesized chemically or extracted naturally from herbs like Mucuna Pruriens (MP). Clinical research shows that MP extract containing L-DOPA reduces side effects compared to the synthetic one. However, MP extracts are prone to degradation, so it is necessary to develop a stable extraction procedure.
Article
Biochemistry & Molecular Biology
Narisa Kamkaen, Chuda Chittasupho, Suwanna Vorarat, Sarin Tadtong, Watoo Phrompittayarat, Siriporn Okonogi, Pakakrong Kwankhao
Summary: L-dopa derived from Mucuna pruriens seed extract shows significant neuroprotective activity and may be a more beneficial treatment for Parkinson's disease compared to synthetic L-dopa.
Article
Food Science & Technology
Stephanie Vazquez Encalada, Maira Rubi Segura Campos
Summary: The evaluation of fiber residues from Mucuna pruriens bean revealed high nutritional value, strong functional properties including water holding capacity, and significant antioxidant potential attributed to phenols and flavonoids. The fiber demonstrated promising dietary benefits and could be a valuable ingredient in food and nutrition industries.
FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Chita Ranjan Sahoo, Jyotirmaya Sahoo, Monalisa Mahapatra, Debananda Lenka, Pratap Kumar Sahu, Budheswar Dehury, Rabindra Nath Padhy, Sudhir Kumar Paidesetty
Summary: Bacterial infections are significant health threats worldwide, with antibiotic resistance posing a challenge. The development of new potential drug candidates is necessary to combat multidrug-resistant bacteria. Coumarin and its derivatives have been reported to have broad inhibitory properties, with substituents at positions C-3 and C-4 shown to be coveted for the development of newer antibacterial agents.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Debashish Mohapatra, Srikant Kanungo, Sweta Priyadarshini Pradhan, Susmita Jena, Shakti Ketan Prusty, Pratap Kumar Sahu
Summary: In this study, the effects of Captopril and Perindopril on cognitive dysfunction and amyloidogenesis induced by aluminium chloride were evaluated and compared. The results showed that both Captopril and Perindopril prevented and improved cognitive dysfunction, reduced amyloid-beta content, and improved antioxidant status. They also reversed the histopathological changes in the hippocampus region. Captopril was found to be more effective than Perindopril.
Article
Pharmacology & Pharmacy
Sweta Priyadarshini Pradhan, Sonali Sahoo, Anindita Behera, Rajesh Sahoo, Pratap Kumar Sahu
Summary: The present study aimed to investigate the potential and efficacy of hesperidin gold nanoparticles (HSP-AuNPs) for memory enhancement in a diabetes-induced cognitive impairment model. The results showed that HSP-AuNPs exhibited significant antioxidant activity and protective effects, and increased the availability of hesperidin in the brain.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Spectroscopy
Sweta Priyadarshini Pradhan, Sunsita Swain, Nishigandha Sa, Satya Narayan Pilla, Anindita Behera, Pratap Kumar Sahu, Sudam Chandra Si
Summary: Nanomaterials have unique properties that make them potentially useful in biomedical applications and environmental pollutant management. This research focuses on isolating hesperidin from orange peel and preparing hesperidin gold nanoparticles using a chemical reduction method. The gold nanoparticles have high substrate specificity and can be excited by visible light. They show excellent efficacy in managing and removing organic pollutants. The study also demonstrates that hesperidin gold nanoparticles have significant antioxidant and photocatalytic activity, making them valuable in disease management and wastewater treatment.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Pharmacology & Pharmacy
Nishigandha Sa, P. Tejaswani, Sweta Priyadarshini Pradhan, Khider Ali Alkhayer, Anindita Behera, Pratap Kumar Sahu
Summary: Diabetes is a chronic metabolic disorder that causes complications due to oxidative stress and cell damage. Plant-derived phytomolecules with super-antioxidant properties show promise in treating diabetes. Metal nanoparticles, synthesized using a green approach, exhibit significant anti-diabetic and antioxidant activities in a diabetic rat model.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sweta Priyadarshini Pradhan, P. Tejaswani, Nishigandha Sa, Anindita Behera, Rajesh Kumar Sahoo, Pratap Kumar Sahu
Summary: The present study investigates the efficacy of antidiabetic drug VLD and antioxidant VE against STZ-induced diabetic cognitive impairment. To enhance the efficacy of VLD, gold nanoparticles are conjugated with VLD for targeted brain delivery. The treatment with drug-conjugated Au NPs improves cognitive functions and shows neuroprotective action against diabetes-induced cognitive impairment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Cell Biology
Sweta Priyadarshini Pradhan, Pratap Kumar Sahu, Anindita Behera
Summary: Alzheimer's disease (AD) and type-II diabetes mellitus (DM) are mutually related chronic neurodegenerative disorders. Chronic DM increases the risk for AD due to insulin resistance and cognitive dysfunction. Repurposing of antidiabetic drugs and nanotechnological interventions show promise in the prevention and treatment of AD. This review explores the cellular and molecular pathophysiologies of AD and type-II DM, the use of in vivo DM models in AD studies, and the potential of antidiabetic drugs and nanodelivery systems for AD treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Neurosciences
Anindita Behera, Sweta Priyadarshini Pradhan, P. Tejaswani, Nishigandha Sa, Swagata Pattnaik, Pratap Kumar Sahu
Summary: Diabetes mellitus leads to cognitive dysfunction due to insulin deficiency. Hesperidin, a bioflavonoid, has poor solubility and a short half-life. To overcome these limitations, hesperidin was conjugated with gold, selenium, and core-shell bimetallic nanoparticles. The synthesized nanoparticles showed neuroprotective effects in a rat model of cognitive dysfunction induced by streptozotocin. Among the nanoparticles, the bimetallic Se@Au-HSP NPs exhibited the strongest neuroprotective action. Hesperidin-conjugated bimetallic nanoparticles could be a potential alternative for neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Anindita Behera, Nishigandha Sa, Sweta Priyadarshini Pradhan, Sunsita Swain, Pratap Kumar Sahu
Summary: Nanotechnology is being applied in various biomedical fields, such as lifestyle diseases and neurodegenerative diseases. Metal nanoparticles are widely used as drug delivery systems due to their enhanced physicochemical properties. This review article discusses the neuroprotective and neurotoxic effects of different metal nanoparticles on Alzheimer's disease, as well as their biocompatibility for brain targeting. It also analyzes the need for new drug delivery systems and offers guidance for researchers in brain-targeted drug delivery for Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE REPORTS
(2023)
Article
Medicine, General & Internal
Sunita Mishra, Shakti Ketan Prusty, Pratap Kumar Sahu, Debajyoti Das
Summary: This study evaluated the efficacy of Azilsartan against aluminium chloride induced Alzheimer's disease (AD). The results showed that both Azilsartan and Telmisartan significantly improved cognitive dysfunction, enhanced antioxidant status, and reduced A beta production. However, the protective effect of Azilsartan was found to be slightly weaker than Telmisartan.
CURRENT ISSUES IN PHARMACY AND MEDICAL SCIENCES
(2023)
Review
Multidisciplinary Sciences
Dhananjay Panigrahi, Pratap Kumar Sahu, Suryakanta Swain, Rajan Kumar Verma
Summary: The Quality by Design approach helps minimize experimental trials and time, identifying key factors impacting product quality. The double emulsion method for preparing PLGA nanoparticles is complex but remains an alternative pharmaceutical manufacturing operation for obtaining quality products.
SN APPLIED SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ranjit Prasad Swain, Pratap Kumar Sahu
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2020)
Article
Pharmacology & Pharmacy
Shakti Ketan Prusty, Pratap Kumar Sahu
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2020)
Article
Medicine, General & Internal
Sweta Priyadarshini Pradhan, Pratap Kumar Sahu
JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY
(2020)
Article
Education, Scientific Disciplines
Dibya Sundar Panda, Mohammed Gamal, Ameeduzzafar Zafar, Della Grace Thomas Parambi, Aswini Kumar Senapati, Soraja Kumar Patro, Pratap Kumar Sahoo, Anindya Bose
PHARMACY EDUCATION
(2020)
