Journal
INDIAN JOURNAL OF PHARMACOLOGY
Volume 42, Issue 1, Pages 2-8Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0253-7613.62395
Keywords
Angiogenesis; antiangiogenic drugs; vascular endothelial growth factor
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Angiogenesis is a fundamental biological process that is regulated by a fine balance between pro-and antiangiogenic molecules, and is deranged in various diseases. Historically, angiogenesis was only implicated in few diseases, such as, cancer, arthritis, and psoriasis. However, in recent years, it has been increasingly evident that excessive, insufficient or abnormal angiogenesis contributes to the pathogenesis of many more disorders. Research in angiogenesis offers a potential to cure a variety of diseases such as Alzheimer's and AIDS. Modulation of angiogenesis may have an impact on diseases in the twenty-first century similar to that which the discovery of antibiotics had in the twentieth century.
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