Review
Biotechnology & Applied Microbiology
Rongxin Zhang, Meiya Jiang, Wenyi Lei, Aoxue Wang
Summary: Acanthosis nigricans (AN) is a rare cutaneous condition that may indicate certain endocrinological or autoimmune diseases, as well as undiagnosed cancer. Malignant acanthosis nigricans (MAN) is associated with advanced cancer, typically intra-abdominal malignancies.
ONCOTARGETS AND THERAPY
(2021)
Review
Medicine, General & Internal
Andreea-Maria Radu, Mara Carsote, Mihai Cristian Dumitrascu, Florica Sandru
Summary: Acanthosis nigricans (AN) is associated with insulin resistance (IR), typically manifesting as metabolic complications such as obesity, diabetes mellitus, and metabolic syndrome. The prevalence of AN varies among different populations, but there is a concerning increase in cases of obesity and metabolic syndrome in younger populations.
Review
Dermatology
Ahmed I. Mourad, Richard M. Haber
Summary: Drug-induced acanthosis nigricans is a rare subtype of acanthosis nigricans with limited data in the literature. A comprehensive literature search identified 13 drugs that can induce acanthosis nigricans, with nicotinic acid and insulin being the most significant. This study created a revised classification system for clinicians to refer to.
DERMATOLOGIC THERAPY
(2021)
Article
Pediatrics
Valeria Calcaterra, Annalisa De Silvestri, Laura Schneider, Miriam Acunzo, Viola Vittoni, Giulia Meraviglia, Francesco Bergamaschi, Gianvincenzo Zuccotti, Chiara Mameli
Summary: The prevalence of Acanthosis nigricans (AN) is higher in patients with type 1 diabetes and obesity compared to controls. Individuals with AN tend to be older, have higher BMI, waist circumference, fasting triglycerides, and blood pressure. The presence of AN is associated with insulin resistance in patients with obesity, while in type 1 diabetes, it is linked to being overweight or obese independent of insulin resistance. The interplay between impaired insulin signaling, insulin resistance, and excess weight plays a role in the pathogenic mechanism of AN.
Article
Dermatology
Rama Godse, Corinne Rauck, Rachel Woods, Katherine T. Steele, Rosalie Elenitsas
Summary: In this article, two rare cases of insulin-derived amyloidosis (AIns) accompanied by acanthosis nigricans (AN)-like changes are described. Additionally, the first case of an AIns nodule being misdiagnosed as a keloid is reported. Accurate diagnosis is crucial due to the potential impact on glycemic control.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Jinling Wang, Hu Lin, Valentina Chiavaroli, Binghan Jin, Jinna Yuan, Ke Huang, Wei Wu, Guanping Dong, Jose G. B. Derraik, Junfen Fu
Summary: This study describes the clinical characteristics and prevalence of cardiometabolic comorbidities among children and adolescents with obesity in China over a 10-year period. The findings highlight the high incidence of obesity-related comorbidities and the concerning increase in rates over time, emphasizing the importance of early intervention to prevent the development of obesity-related complications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dermatology
Chawan Kritsanaviparkporn, Arucha Treesirichod
Summary: The study compares the efficacy and safety profile of 0.025% and 0.05% tretinoin creams in managing acanthosis nigricans (AN). Both concentrations were found to be effective in treating AN, with no significant differences in efficacy, scoring, and local irritations.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Alex Hines, Afsaneh Alavi, Mark D. P. Davis
Summary: Diabetes mellitus is a significant global health issue, with increasing prevalence worldwide, especially in high-income countries. It negatively impacts quality of life and increases mortality rates, with Type 2 DM being the most common form. Cutaneous manifestations of diabetes are common and range from benign to life-threatening conditions.
MEDICAL CLINICS OF NORTH AMERICA
(2021)
Article
Endocrinology & Metabolism
Laura Hasse, Dagmar Jamiolkowski, Felix Reschke, Kerstin Kapitzke, Jantje Weiskorn, Olga Kordonouri, Torben Biester, Hagen Ott
Summary: This study reveals a high prevalence of skin lesions in children and adolescents with obesity, which are associated with increasing BMI and age. The HOMA score is associated with acanthosis nigricans, keratosis pilaris, and acne vulgaris, indicating that skin manifestations are a marker of insulin resistance. Thorough skin examinations and interdisciplinary cooperation are necessary for the prevention and improvement of quality of life.
ENDOCRINE CONNECTIONS
(2023)
Review
Medicine, General & Internal
Atif Munir, Miqdad Haider, Aijaz Zeeshan Khan Chachar
Summary: BSCL is a rare genetic disorder that leads to an absolute deficiency of adipose tissue and can cause severe insulin resistance. It is important to consider this condition when managing young patients with insulin resistance.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Endocrinology & Metabolism
Waldemar B. Minich, Brent S. Abel, Christian Schwiebert, Tim Welsink, Petra Seemann, Rebecca J. Brown, Lutz Schomburg
Summary: This study aimed to establish a robust in vitro method for quantification of insulin receptor autoantibodies (InsR-aAb). A bridge assay for the detection of InsR-aAb was established using recombinant human insulin receptor as bait and detector in longitudinal serum samples from TBIR patients. The novel assay proved to be sensitive, robust, and passed quality control, allowing for identification of TBIR and monitoring of successful therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Public, Environmental & Occupational Health
Ahmad Kamil Nur Zati Iwani, Muhammad Yazid Jalaludin, Farah Aqilah Roslan, Fazliana Mansor, Fuziah Md Zain, Janet Yeow Hua Hong, Ruziana Mona Wan Mohd Zin, Abqariyah Yahya, Zahari Ishak, Rusidah Selamat, Abdul Halim Mokhtar
Summary: This study investigated the prevalence and clinical characteristics of cardiometabolic risk factors among severely obese children in Malaysia. The results showed that severely obese children had a higher prevalence of these risk factors compared to overweight and obese children. This highlights the importance of regular screening and intervention for this group of children.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Genetics & Heredity
Umi Tahara, Masahito Yasuda, Yozo Yamada, Satomi Aoki, Showbu Sato, Masayuki Amagai, Akiharu Kubo
Summary: Mutations in FGFR3 can cause familial acanthosis nigricans, with the c.2302G>T (p.E768*) mutation being a unique autosomal dominant nonsense mutation.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Surgery
Cuiling Zhu, Xin Wen, Hui You, Liesheng Lu, Lei Du, Chunhua Qian
Summary: This study aimed to investigate insulin secretion patterns, beta-cell function, and serum prolactin (PRL) concentrations in Chinese morbidly obese patients with Acanthosis nigricans (AN) and their alterations after laparoscopic sleeve gastrectomy (LSG). The results showed that AN patients had delayed and impaired insulin secretion before surgery, but these were significantly improved after LSG. Serum PRL decreased in the AN group at baseline but increased post-LSG. Elevated PRL was associated with improved insulin secretion and decreased insulin resistance.
Article
Dermatology
Fatma Eldeeb, Reham M. Wahid, Rania Alakad
Summary: Both fractional CO2 laser and TCA peel were effective in treating pseudo-acanthosis nigricans, but the fractional CO2 laser group showed significantly higher therapeutic response and fewer adverse effects compared to the TCA peel group.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
