Article
Chemistry, Applied
Yan-Hong Xue, Ao Li, Hui Li, Chao Liu, Hua-Jun Luo, Cheng-Xiong Liu, Jian-Feng Chen, Kun Zou, Shi-Ping Liu
Summary: The biocontrol fungus Chaetomium globosum QY-1 near the orchard was found to have antimicrobial, antioxidant, and tyrosinase inhibition activity, with metabolites showing strong inhibition to Penicillium digitatum and high antioxidant and tyrosinase inhibitory activity. This suggests that the metabolites of C. globosum have the potential to be used as natural preservatives with comprehensive effects.
Article
Chemistry, Medicinal
Jiacheng Ji, Chang Liu, Xuhui He, Guilin Chen, Luping Qin, Chengjian Zheng
Summary: Two new 19,20-seco-chaetoglobosins, salchaetoglobosins A and B, along with three known analogues, were isolated from the solid rice culture of Chaetomium globosum D38, an endophytic fungus derived from Salvia miltiorrhiza, and their structures and biological activities were evaluated.
Article
Biochemical Research Methods
Sunayana Ningaraju, Uzma Munawer, Vinay Basavegowda Raghavendra, Kyathegowdanadoddi Srinivasa Balaji, Govindappa Melappa, Kathirvel Brindhadevi, Arivalagan Pugazhendhi
Summary: The study focused on synthesizing gold nanoparticles using the fungal endophyte Chaetomium globosum isolated from Vitex negundo. The nanoparticles showed potential cytotoxicity against HeLa cells and significant anti-inflammatory activity, offering insights for future clinical studies.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Plant Sciences
Yingdan Yuan, Mengting Zu, Jiajia Zuo, Runze Li, Liping Yang, Jun Tao
Summary: Plants can enhance their resistance to environmental stress by interacting with beneficial endophytic fungi. Salt stress is a major threat to plant growth worldwide. In this study, we investigated the response mechanism of the salt-tolerant fungus Chaetomium globosum D5 and its role in helping Paeonia lactiflora alleviate salt stress. We found that C. globosum D5 can resist salt stress by forming dense hyphae and producing more pigments, soluble proteins, and antioxidants. It also helps P. lactiflora promote growth and photosynthesis by increasing nutrient uptake and reducing ion stress in the roots and leaves.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Li Zhang, Li Ma, Yaping Pan, Xinxin Zheng, Qi Sun, Zichao Wang, Qi Wang, Hanzhen Qiao
Summary: The study found that low molecular weight polysaccharides have higher inhibitory effects against Escherichia coli and Staphylococcus aureus compared to high molecular weight polysaccharides, with stronger activity against the latter. Additionally, the minimum inhibitory concentrations of low molecular weight polysaccharides were lower than those of high molecular weight polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Jiaxin Zhang, Md. Samiul Islam, Jieyu Wang, Yang Zhao, Wubei Dong
Summary: In this study, two antimicrobial peptides (CgR2150 and CgR3101) with broad-spectrum antibacterial activities were identified from endophytes isolated from potato tubers. These peptides showed excellent stability and could significantly inhibit the growth of various bacteria and fungi. Scanning electron microscopy revealed that these peptides disrupt bacterial cell membranes. The findings suggest that CgR2150 and CgR3101 have potential as new antibacterial agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Yan Zhang, Xiang-Mei Tan, Meng Yu, Jian Yang, Bing-Da Sun, Jian-Chun Qin, Lan-Ping Guo, Gang Ding
Summary: New metabolites globosumin and globosumone were isolated from the endophytic fungus Chaetomium globosum, showing inhibitory effects on Arabidopsis thaliana seedling growth and cancer cell lines A549 and HepG2, with Chaetoglobosin A demonstrating dose-dependent biological activity.
Article
Nutrition & Dietetics
Li Ma, Xueliang Guo, Jiaoyang Yang, Xiangru Zeng, Kaili Ma, Lu Wang, Qi Sun, Zichao Wang
Summary: In this study, a polysaccharide was successfully produced from sugarcane molasses. The polysaccharide contained various sugars and exhibited crystalline and amorphous structures. It showed antibacterial activity, with higher inhibitory effect on Staphylococcus aureus than on Escherichia coli. This work provides a green method for the production of bioactive polysaccharide from sugarcane molasses.
FRONTIERS IN NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Tolga Demir, Ayse Baris, Serhat Sigirci, Buket Bambul Sigirci, Elif Seren Tanriverdi, Ismail Koramaz
Summary: This case report describes the first documented tricuspid endocarditis caused by Chaetomium species and emphasizes the importance of molecular tools in the diagnosis of culture-negative endocarditis.
CARDIOVASCULAR PATHOLOGY
(2023)
Article
Chemistry, Medicinal
Tantan Li, Yun Wang, Li Li, Mengyue Tang, Qinghong Meng, Cun Zhang, Erbing Hua, Yuehu Pei, Yi Sun
Summary: In this study, four new cytochalasans and twelve known cytochalasans were isolated from a mangrove-associated fungus. The newly discovered compounds showed moderate cytotoxicity against A549 and HeLa cell lines. These findings provide valuable insights into the potential medicinal properties of these cytochalasans.
Article
Biotechnology & Applied Microbiology
Shanshan Zhao, Congyu Lin, Ming Cheng, Kai Zhang, Zhengran Wang, Tong Zhao, Qian Yang
Summary: Chaetoglobosin A is a complex macrocyclic alkaloid with potent antimycotic, antiparasitic, and antitumor properties. This study identified the crucial role of the CgMfs1 gene in chaetoglobosin A biosynthesis, showing that inactivation of CgMfs1 decreases yield while overexpression increases it. Additionally, using cornstalk as a fermentation substrate can enhance chaetoglobosin A production, offering a novel strategy for high-yielding strain construction.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zichao Wang, Xueyan Zhou, Xiaona Liang, Xinxin Zheng, Zhihan Shu, Qi Sun, Qi Wang, Na Li
Summary: In this study, a polysaccharide (GCP-TS) derived from tapioca starch by the endophytic fungus Chaetomium globosum CGMCC 6882 in Gynostemma pentaphyllum herb was analyzed. GCP-TS exhibited concentration-dependent scavenging ability against various radicals and enhanced antibacterial activity against Staphylococcus aureus and Escherichia coli with increasing concentrations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yun Zhang, Heqin Zhu, Yonghao Ye, Canming Tang
Summary: The biocontrol agent CEF-082 and its metabolic products can reduce the incidence of Cotton Verticillium wilt and enhance the sensitivity of Verticillium dahliae to stress. The active compound chaetoviridin A is highly effective against V. dahliae and enhances the defense response of cotton plants.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Article
Plant Sciences
Nicholas J. J. Morehouse, Trevor N. N. Clark, Russell G. G. Kerr, John A. A. Johnson, Christopher A. A. Gray
Summary: Two new caryophyllenesesquiterpenes, Punctaporonins T and U, along with three known punctaporonins A, B, and C, were isolated from the endophytic fungus Chaetomium globosum (TC2-041). The structures and relative configurations of Punctaporonins T and U were determined using HRESIMS, 1D/2D NMR spectroscopy, and X-ray diffraction analysis. The absolute configuration of these compounds was presumed based on the biogenetic arguments with the co-isolated compounds 3-5. Compound 1 exhibited weak inhibitory activity against both Mycobacterium tuberculosis and Staphylococcus aureus.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Applied
Li Cheng, Xi Zheng, Qin Li, Meng-Sha Wei, Chun-Mei Chen, Hu-Cheng Zhu, Chang-Li Zeng, Xin-Cai Hao, Yong-Hui Zhang
Summary: Two novel cytochalasans, armochaetoglasin J and armochaetoglasin K, were isolated from Chaetomium globosum along with 14 known analogues. Their structures were elucidated using various techniques, but both armochaetoglasins J and K were found to be inactive against several cancer cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Xiang-hui Zhang, Dong-jing Zhang, Jin-liang Liu, Hong-yu Pan, Jian-chun Qin, Yan-hua Zhang
BIOCONTROL SCIENCE AND TECHNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Chenggang Song, Gang Ding, Gang Wu, Jian Yang, Mingzhe Zhang, Haoyu Wang, Dongsheng Wei, Jianchun Qin, Lanping Guo
CHEMISTRY & BIODIVERSITY
(2020)
Article
Biochemistry & Molecular Biology
Chenggang Song, Juan Liu, Haoyu Wang, Xiang Li, Bing Liu, Mingzhe Zhang, Xiaohui Shan, He Li, Jinming Gao, Jianchun Qin
CHEMISTRY & BIODIVERSITY
(2020)
Article
Food Science & Technology
Sheng-xiang Yang, Bing Liu, Mei Tang, Jian Yang, Yi Kuang, Ming-zhe Zhang, Chun-ying Zhang, Chao-yi Wang, Jian-chun Qin, Lan-ping Guo, Li-chun Zhao
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2020)
Review
Biochemistry & Molecular Biology
Chenggang Song, Jian Yang, Mingzhe Zhang, Gang Ding, Chengguo Jia, Jianchun Qin, Lanping Guo
Summary: Marine habitats harbor a rich diversity of biological resources, including marine plants, animals, and microorganisms. Marine natural products with diverse structures and insecticidal activity have broad applications for future research in agriculture and health.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Agriculture, Multidisciplinary
Chenggang Song, Mingyue Wu, Yanxin Zhang, Jie Li, Jian Yang, Dongsheng Wei, He Li, Lanping Guo, Jianchun Qin
Summary: Two new polyketides and a new natural product, along with 13 known compounds, were isolated from the edible mushroom Cortinarius purpurascens. These compounds exhibited excellent inhibition effects on glutamate dehydrogenase and significant antioxidant activities. Cortinarius caerulescens could be a novel resource for food selection and drug discovery.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Correction
Agriculture, Multidisciplinary
Chenggang Song, Mingyue Wu, Yanxin Zhang, Jie Li, Jian Yang, Dongsheng Wei, He Li, Lanping Guo, Jianchun Qin
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yan-Duo Wang, Cheng-Gang Song, Jian Yang, Tao Zhou, Yu-Yang Zhao, Jian-Chun Qin, Lan-Ping Guo, Gang Ding
Summary: Analysis, purification, and characterization of AFB(1) degraded products are essential for understanding the photocatalytic mechanism. The integrated approach of UPLC-Q-TOF-MS/MS technique, purification, NMR spectral experiments, and biological tests proved effective for analysis, characterization, and toxic evaluation of AFB(1) degraded products, with potential applications in other mycotoxin degradation processes.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Wei Chen, Jinglei Xiao, Chenggang Song, Mingyue Wu, Xinglin Du, Dongsheng Wei, Yilin Qiao, Xianghui Zhang, Jianchun Qin
Summary: Eleven compounds were isolated from M. polymorpha, including a previously undescribed compound and ten known compounds. The structures of compound 1 were determined and identified as pentacyclic triterpenoid derivative. Compound 7 showed significant antifungal and insecticidal activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Food Science & Technology
Chenggang Song, Jianchun Qin
Summary: Mycotoxins are highly toxic secondary metabolites produced by food-borne fungi that can contaminate food and feed, posing serious health risks. Nano-adsorbents, particularly in combination forms, show promising results for removing mycotoxins. This study presents a systematic review of the latest literature on various nano-adsorbents for mycotoxin elimination, summarizing their synthesis, performance, security, and adsorption mechanisms. It aims to provide an extensive overview, highlight limitations in current research, and inspire future research on mycotoxin control.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoqing Hu, Yimeng Yang, Shi Tang, Qiuyan Chen, Meiyu Zhang, Jiaoyan Ma, Jianchun Qin, Huimei Yu
Summary: This study evaluated the anti-aging effects of anthocyanin extracted from the fruits of Sambucus canadensis. The results showed that anthocyanin can significantly reduce cell senescence and aging of the lens by inhibiting the activity of the PI3K/AKT/mTOR signaling pathway. It promotes the apoptosis of senescent cells, increases autophagic and mitophagic flux, enhances mitochondrial renewal and cell homeostasis, thus attenuating aging. Therefore, anthocyanin can be used as a potential senolytic in anti-aging therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuanyang Li, Yubin Zhang, Bin Li, Liyuan Hou, Jianing Yu, Chengguo Jia, Zhe Wang, Siqi Chen, Mingzhe Zhang, Jianchun Qin, Ning Cao, Jinhu Cui, Wuliang Shi
Summary: This study investigated the biological functions of the maize OSCA gene family using bioinformatics and expression analysis. The results revealed significant expression differences of the ZmOSCA genes in different tissues and under various abiotic stress conditions. Protein interaction prediction was conducted, providing new findings. These results contribute to the understanding of the molecular mechanisms involved in plant osmotic stress and response, as well as providing a theoretical basis for crop breeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Cheng-Gang Song, Yu-Qing Liu, Gang Ding, Jian Yang, Chun-Yu Wang, Jia-Rui Wu, Gengxin Wu, Meng-Hao Li, Lan-Ping Guo, Jian-Chun Qin, Ying-Wei Yang
Summary: A novel class of metal-organic framework nanoplatforms has been designed for efficient removal of organic pollutant AFB1. The material exhibits high adsorption and photodegradation capabilities, reducing toxicity and achieving over 90% removal rate. Additionally, the catalysts can be easily recycled while maintaining high catalytic activity.
ACS APPLIED NANO MATERIALS
(2022)
Review
Agriculture, Multidisciplinary
Chao-Yi Wang, Jian-Chun Qin, Ying-Wei Yang
Summary: Phytopathogens, pests, weeds, and nutrient deficiencies are major causes of crop losses worldwide. Agrochemicals play a crucial role in modern agriculture but also contribute to environmental burden due to inefficient use. By introducing nanomaterials into agriculture, nanotechnology offers new opportunities for precise and targeted delivery of agrochemicals, supporting sustainable development in green agriculture. Metal-Organic frameworks (MOFs) have shown great potential in constructing stimuli-responsive nanoplatforms for controlled agrochemical delivery. This review focuses on the recent advancements of MOF-based nanoplatforms in crop protection and growth promotion, including control of phytopathogens, pests, and weeds, and delivery of fertilizers and plant hormones. The challenges and future prospects of MOF-based nanoplatforms in crop protection and growth promotion are also discussed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Applied
Yanxin Zhang, Jinlong Dai, Xiaoyun Ma, Chengguo Jia, Junyou Han, Chenggang Song, Yuqing Liu, Dongsheng Wei, Hongfei Xu, Jianchun Qin, Shengxiang Yang
Summary: The reduction in blueberry harvest due to pathogen infection was reported to reach 80%. Essential oil (EO) and its nano-emulsion (MNE) derived from Monarda didyma L were found to inhibit the growth of pathogenic fungi isolated from blueberries, with MNE exhibiting superior antimicrobial activity and causing morphological changes in the fungi, as well as reducing the rot and weight loss rate of blueberries.
