Journal
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
Volume 35, Issue 2, Pages 325-331Publisher
SPRINGER INDIA
DOI: 10.1007/s12288-018-1003-4
Keywords
Thromboelastography; Point-of-care systems; Blood coagulation tests; TraumaticBrain injuries
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To evaluate the efficacy of point-of-care thromboelastography (TEG) to predict acute trauma-induced coagulopathy (ATIC) in isolated severe TBI (iSTBI). We conducted an observational diagnostic cohort. Patients for whom TEG was performed before blood transfusion were stratified by conventional coagulation tests (CCTs) on admission and classified as ATIC (prothrombin time >= 16.70s; international normalized ratio >= 1.27; activated partial thromboplastin time >= 28.80s) (n=24) or no ATIC (n=34). Univariate analysis to compare groups, receiver operating characteristic analysis to establish cut-off and diagnostic validation was done. Fifty-eight patients were included [32(25-45) years; 97% male; GCS 6.3 +/- 1.5]. 41% developed ATIC. Compared to no-ATIC, ATIC group had significantly prolonged kappa-time (4.6 vs. 2.5min; p=0.01) and shortened alpha-angle (40.2 degrees vs. 56.3 degrees; p=0.03). A cut-off for kappa-time >= 3.7 (AUC 0.68 95% CI 0.54-0.82, specificity 70%, sensitivity 63%) and alpha angle <= 48.0 (AUC 0.66, 95% CI 0.51-0.81, specificity 67%, sensitivity 67%) was established. The diagnostic accuracy of this cut-off for identifying ATIC, was 55.6% with sensitivity (81.8%) and specificity (14.3%). TEG may be a clinically sensitive test for identifying the underlying coagulopathy following TBI. However confirmation with CCTs is recommended.
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