Journal
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
Volume 80, Issue 3, Pages 204-213Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0378-6323.132247
Keywords
Acanthosis; hypogranulosis; lymphomononuclear cells; parakeratosis; psoriasis; severe combined immunodeficiency mice
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Psoriasis is a multifactorial chronic inflammatory disease. Research into the pathogenesis of this disease is hindered by the lack of a proper animal model. Over the past two decades, many scientists were involved in the development of animal models that nearly mirror the immunopathogenesis of psoriasis. One such model, which has opened doors to the study of molecular complexities of psoriasis as well as its treatment, is the severe combined immunodeficiency (SCID) mouse-human skin chimera model. This model not only mirrors the clinical and histopathological features of psoriasis but also help in the study of cell proliferation, angiogenesis, function of T cells, neurogenic inflammation and cytokines involved in inflammatory reactions. In this article, we have reviewed the prospects and the limitations of the SCID mouse model of psoriasis.
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