Review
Allergy
Sander Vandeweege, Britt Debaene, Hilde Lapeere, Hans Verstraelen
Summary: This study reviewed the literature on vulvar allergic contact dermatitis (vACD) and irritative contact dermatitis (vICD), providing a comprehensive reference list of potential vulvar allergens and irritants, and emphasizing the importance of patch testing for identifying causal allergens. Multiple allergens were identified, but not all positive reactions were relevant to the disease. Additional testing methods and late readings should be considered in standard practice. Limited information was found on irritants, highlighting the need for further research.
CONTACT DERMATITIS
(2023)
Article
Dermatology
Jonathan Silverberg, Alexander Hou, Erin M. Warshaw, Howard Maibach, Donald Belsito, Joel G. DeKoven, Kathryn A. Zug, James S. Taylor, Denis Sasseville, Anthony F. Fransway, Vincent A. DeLeo, Melanie D. Pratt, Margo J. Reeder, Amber R. Atwater, Joseph F. Fowler, Matthew J. Zirwas, James G. Marks
Summary: Nearly half of patients with a final diagnosis of SD were also diagnosed with ACD, indicating the importance of patch testing in select SD patients. Patients with a final SD diagnosis had higher odds of allergic reactions to specific allergens compared to those without a final SD diagnosis. The most common relevant allergens in patients with final SD diagnosis were fragrance mix I, Myroxylon pereirae, bacitracin, quaternium-15, and formaldehyde.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Allergy
Jonathan I. Silverberg, Alexander Hou, Erin M. Warshaw, Joel G. DeKoven, Howard I. Maibach, Donald V. Belsito, James S. Taylor, Kathryn A. Zug, Denis Sasseville, Anthony F. Fransway, Vincent A. DeLeo, Melanie D. Pratt, Margo J. Reeder, Joseph F. Fowler, Matthew J. Zirwas, James G. Marks, Amber R. Atwater
Summary: The association between AD and ACD is controversial, with this study analyzing the prevalence, reaction strength, and trends of the most common and relevant allergens in AD patients. Most patients with a history of AD were diagnosed with ACD, and adults with AD history had a higher number of positive patch test reactions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Dermatology
Jonathan Silverberg, Nisha Patel, Erin M. Warshaw, Joel G. DeKoven, Donald Belsito, Amber Reck Atwater, Marie-Claude Houle, James S. Taylor, Margo J. Reeder, Kathryn A. Zug, Denis Sasseville, Vincent A. DeLeo, Melanie D. Pratt, Joseph F. Fowler, Howard Maibach
Summary: This study retrospectively analyzed patch testing data and found differences in patient characteristics, etiologies, and allergens between hand dermatitis, foot dermatitis, and hand-foot dermatitis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
A. Dizdarevic, W. Troensegaard, A. Uldahl, O. Bergendorff, I. Siemund, A. Svensson, A. Sonesson
Summary: In patients with contact dermatitis, an intervention program providing extensive information on specific contact allergies did not significantly improve participants' ability to remember their contact allergy. Efforts to inform and educate should focus on individuals with multiple positive patch test reactions, specific allergens, those over 60 years old, and males for better knowledge and lifestyle changes.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
S. Sahana, S. G. Chethana, G. R. Kanthraj, Jayadev Betkerur
Summary: Hand eczema (HE), foot eczema (FE), and hand-foot eczema (HFE) are commonly caused by various allergens, with nickel being the most common allergen in all three groups. Multiple contact allergies and concurrent reactions with nickel sulfate, potassium dichromate, and cobalt chloride were observed in the study. No significant differences in allergen pattern were observed among HE, FE, and HFE patients.
INDIAN JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Jonathan Silverberg, Erin M. Warshaw, Amber R. Atwater, Howard Maibach, Kathryn A. Zug, Margo J. Reeder, Denis Sasseville, James S. Taylor, Joseph F. Fowler, Melanie D. Pratt, Anthony F. Fransway, Matthew J. Zirwas, Donald Belsito, James G. Marks, Vincent A. DeLeo, Joel G. DeKoven
Summary: This study retrospectively analyzed data from a large number of patients with hand eczema (HE), and found that HE was associated with higher proportions of positive patch tests, with a heterogeneous profile of allergens.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Allergy
Jonathan I. Silverberg, Alexander Hou, Erin M. Warshaw, Howard I. Maibach, Donald V. Belsito, Joel G. DeKoven, Kathryn A. Zug, James S. Taylor, Denis Sasseville, Anthony F. Fransway, Vincent A. DeLeo, Melanie D. Pratt, Margo J. Reeder, Amber R. Atwater, Joseph F. Fowler, Matthew J. Zirwas, James G. Marks
Summary: This retrospective analysis of 38,723 patients from the North American Contact Dermatitis Group found that 23.9% of NE patients were also diagnosed with ACD. The prevalence of NE increased steadily with age and was associated with male sex and Asian ethnicity, but inversely associated with a history of atopic dermatitis and hay fever. NE patients had lower proportions of positive allergic reactions and lower odds of positive reactions to multiple individual allergens.
CONTACT DERMATITIS
(2021)
Article
Multidisciplinary Sciences
Elisabeth A. George, Leslie Castelo-Soccio, Elana Putterman, Helena Kuhn, Carlos Wambier, Abrar Qureshi, Eunyoung Cho
Summary: This study revealed significant associations between AA flare frequency and UV index, precipitation, number of days with rain, number of days with sun, and air pressure. Patients with atopic comorbidities showed stronger correlations with UV index and precipitation, suggesting they may be more susceptible to climate influences. New correlations appeared with temperature, wind speed, and UV index of the prior month, indicating potential mediating effects of climate factors on the seasonal pattern of AA flares. Patients without atopic comorbidities generally exhibited weaker and non-significant correlations between climate and AA flare frequency.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, G. Avila Valle, S. Barbarot, T. Bieber, H. A. Brough, P. Calzavara Pinton, S. Christen-Zach, M. Deleuran, M. Dittmann, C. Dressler, A. H. Fink-Wagner, N. Fosse, K. Gaspar, L. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, C. G. Mortz, A. Nast, U. Nygaard, M. Redding, E. M. Rehbinder, J. Ring, M. Rossi, E. Serra-Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, C. Flohr
Summary: The evidence- and consensus-based guideline on atopic eczema, developed according to the EuroGuiDerm Guideline and Consensus Statement Development Manual, involves the participation of 29 experts from 12 European countries. The first part of the guideline provides general information, guidance, and detailed information on systemic treatment options, including conventional immunosuppressive drugs, biologics, and janus kinase inhibitors. The second part will cover other aspects of treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Letter
Dermatology
Nicole S. Stefanko, Victor L. Quan, Raj Chovatiya
Summary: This study investigates the diagnostic delay in an autoimmune skin disease. The use of C3d and C4d immunohistochemistry is found to be a valuable tool in the diagnosis of inflammatory skin diseases.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Allergy
Aude Clement, Marie-Christine Ferrier le Bouedec, Marie-Noelle Crepy, Nadia Raison-Peyron, Florence Tetart, Pierre Marcant, Pauline Pralong, Aude Valois, Justine Pasteur, Haudrey Assier, Claire Bernier, Marie-Therese Le Cam, Florence Hacard, Audrey Nosbaum, Francoise Giordano Labadie, Cecile Morice, Camille Leleu, Brigitte Milpied, Anne-Sophie Darrigade, Juliette Delaunay, Annick Barbaud, Florence Castelain, Evelyne Collet, Emmanuelle Amsler
Summary: This study investigated the clinical profile of glove-wearing patients with hand eczema and evaluated their sensitization profile to glove allergens and the value of testing the patients' own gloves. The results showed that testing with the European rubber series (ERS) is more effective in detecting glove allergy compared to the European baseline series (EBS). It is recommended to test all patients' gloves, including PVC gloves.
CONTACT DERMATITIS
(2023)
Article
Allergy
Victoria L. Murphy, Denesh C. Patel, Steven R. Lamb, Harriet S. Cheng
Summary: The study found a sensitization rate of 4.4% to at least one corticosteroid tested in Auckland, New Zealand through patch testing. Using the full steroid series, in addition to the European Baseline Series, was able to detect one additional case of corticosteroid allergy with a number needed to test of 107. Up to 11 out of 14 corticosteroid reactions were to tixocortol pivalate or budesonide.
CONTACT DERMATITIS
(2021)
Review
Biochemistry & Molecular Biology
Jamie Afghani, Claudia Traidl-Hoffmann, Philippe Schmitt-Kopplin, Matthias Reiger, Constanze Mueller
Summary: Atopic eczema is an inflammatory skin disorder that affects approximately 20% of children worldwide, and early onset can lead to other allergic diseases. Metabolomics can be used to observe the mechanisms of this disease and potentially discover new drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Laura Loman, Wolfgang Uter, Jose C. Armario-Hita, Fabio Ayala, Anna Balato, Barbara K. Ballmer-Weber, Andrea Bauer, Andreas J. Bircher, Timo Buhl, Magdalena Czarnecka-Operacz, Heinrich Dickel, Thomas Fuchs, Ana Gimenez Arnau, Swen M. John, Birger Kraenke, Beata Krecisz, Vera Mahler, Thomas Rustemeyer, Anna Sadowska-Przytocka, Javier Sanchez-Perez, Kathrin Scherer Hofmeier, Sibylle Schliemann, Dagmar Simon, Radoslaw Spiewak, Philip Spring, Skaidra Valiukeviciene, Nicola Wagner, Elke Weisshaar, Maria Pesonen, Marie L. A. Schuttelaar
Summary: ICD is primarily located in the hands and face, with a significant proportion of occupational ICD occurring in metal turners, bakers, pastry cooks, and confectionery makers. Additionally, a portion of patients diagnosed with ICD were found to have sensitization unrelated to their current disease.
CONTACT DERMATITIS
(2021)