Activated charcoal and baking soda to reduce odor associated with extensive blistering disorders

Summary: This study retrospectively reported eight cases of severe mucocutaneous blistering eruptions associated with SARS-CoV-2 infection, with a clinical diagnosis mainly of RIME. Oral mucosal involvement was the most common, followed by ocular and urogenital involvement. Additionally, evidence of concurrent or previous infections was found in some patients.

Summary: Although the identification of genes involved in NDDs has improved our understanding of their causes, obstacles still remain in developing therapies for ID and other NDDs due to clinical and genetic heterogeneity, rarity of recurrent pathogenic variants, and comorbidity with psychiatric traits. A broad range of clinical symptoms in some NDDs is caused by a large intragenic mutational landscape, with different DNA variations affecting protein functions and downstream processes. This review focuses on understanding the molecular changes of group I PAKs and their contribution to the clinical spectrum of NDDs. By identifying differences in PAK structure, regulation, and expression, we can uncover the mechanisms underlying mutation pathogenicity and develop personalized therapeutic approaches.

Summary: This meta-analysis identified increased immune activation, inflammation, neurotoxicity, and decreased neuroprotection in patients with suicide attempts compared to healthy controls and patients with fewer suicide attempts.

Summary: This case report describes a patient with LETM associated with Dengue virus infection who responded well to treatment. A systematic review of published cases found three additional cases meeting criteria for NMOSD. The study suggests that early appropriate immunotherapy is crucial for patients suspected of having NMOSD.

Summary: BIA-ALCL, though declining clinically, is still an important topic in breast implant safety discussions. Plastic surgeons need to understand the disease progression and classification, use high-level surgical techniques to reduce bacterial load, and practice evidence-based surgery with vigilant postoperative follow-up care to improve outcomes.