Article
Medicine, General & Internal
Renee Heffron, Timothy R. Muwonge, Katherine K. Thomas, Florence Nambi, Lylianne Nakabugo, Joseph Kibuuka, Dorothy Thomas, Erika Feutz, Allison Meisner, Norma C. Ware, Monique A. Wyatt, Jane M. Simoni, Ingrid T. Katz, Herbert Kadama, Jared M. Baeten, Andrew Mujugira
Summary: Integration of PrEP into ART clinics reached a high proportion of people in HIV-serodifferent relationships and did not improve the already high frequency of HIV viral suppression among partners living with HIV.
Article
Public, Environmental & Occupational Health
Elizabeth M. Irungu, Kenneth K. Mugwanya, Nelly R. Mugo, Elizabeth A. Bukusi, Deborah Donnell, Josephine Odoyo, Elizabeth Wamoni, Sue Peacock, Jennifer F. Morton, Kenneth Ngure, Mary Mugambi, Irene Mukui, Gabrielle O'Malley, Jared M. Baeten
Summary: Through a trial integrating PrEP delivery in public HIV care clinics in Kenya, high uptake, reasonable continuation with high adherence, frequent PrEP restarts, and low HIV incidence were observed, demonstrating the feasibility of integrating PrEP services within public HIV care clinics in Africa.
LANCET GLOBAL HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Xiaoming Li, Shan Qiao, Xueying Yang, Sayward E. Harrison, Cheuk Chi Tam, Zhiyong Shen, Yuejiao Zhou
Summary: Despite long-standing global efforts to address HIV-related stigma, previous interventions have shown limited effectiveness. Recent studies suggest that resilience-based approaches may hold promise for reducing HIV-related stigma, but large-scale empirical testing in resource-limited settings is rare.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pediatrics
Katherine Merseth King, Seng Yeng, Claire Brennan, Darryl Creel, John W. Ames, Gwyneth Cotes, Carla M. Bann, Maureen M. Black
Summary: This article introduces a cluster randomized controlled trial conducted in Cambodia to evaluate the impact of an integrated, multisector intervention on children's development. By partnering with the Royal Government of Cambodia and addressing intervention pathways and moderators, this trial aims to provide guidance for policies and programs to promote early childhood development.
Article
Public, Environmental & Occupational Health
Yongjie Sha, Chunyan Li, Yuan Xiong, Aniruddha Hazra, Jonathan Lio, Ivy Jiang, Haojie Huang, Jared Kerman, Jannelle Molina, Linghua Li, Ke Liang, Dandan Gong, Quanmin Li, Songjie Wu, Renslow Sherer, Joseph D. Tucker, Weiming Tang
Summary: This study aims to develop interventions to increase PrEP adherence among key populations in China using co-creation methods. The efficacy of the co-created interventions will be evaluated through a stepped-wedge randomized controlled trial. The study design addresses barriers such as low PrEP uptake and lack of effective service delivery models, and embeds the study in the local healthcare system.
Article
Health Care Sciences & Services
Richard Hooper
Summary: A stepped wedge trial is an evaluation method of implementing interventions over a staggered timetable, usually cluster randomized, with various designs and conduct practices. The analysis of this trial assumes a constant intervention effect and the need to adjust for period effects, underlying trends, and clustering of outcomes. The advantage lies in practicality or statistical efficiency.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Geriatrics & Gerontology
Anders Fournaise, Jorgen T. Lauridsen, Mickael Bech, Uffe K. Wiil, Jesper B. Rasmussen, Kristian Kidholm, Kurt Espersen, Karen Andersen-Ranberg
Summary: The PATINA study aims to evaluate the effect of the 'PATINA algorithm and decision support tool' in alerting community nurses of older citizens showing subtle signs of declining health and increased risk of acute admission. A stepped-wedge cluster randomized controlled trial will be conducted in 20 home care teams across three Danish municipalities. The primary outcome is acute admission with secondary outcomes including readmissions, preventable admissions, death, and costs of health care utilization.
Article
Multidisciplinary Sciences
Sugy M. Choi, Megan O'Grady, Charles Cleland, Elizabeth Knopf, Sueun Hong, Thomas S. D'Aunno, Yuhua J. Bao, Kelly Ramsey, Charles Neighbors
Summary: This study aims to develop and test a multidimensional intervention for opioid treatment programs (OTPs) in order to improve their ability to appropriately use take-home dosing (THD) of methadone during the COVID-19 pandemic. By analyzing large state administrative data and conducting qualitative interviews, the researchers will develop and refine the intervention and evaluate its impact on both organizational and patient outcomes. This research is important for improving medication treatment and informing policy making.
Article
Mathematical & Computational Biology
Satya Prakash Singh
Summary: This study discusses the use of Bayesian methods in designing stepped wedge trials to address the issue of dependency among individuals. The robustness of Bayesian design is demonstrated by exploring various choices of priors, and its superiority over the commonly used balanced design is numerically demonstrated using hypothetical and real scenarios.
BIOMETRICAL JOURNAL
(2023)
Article
Nursing
Xiaoxia Qiao, Lili Ji, Yaru Jin, Huaxin Si, Yanhui Bian, Wenyu Wang, Qinqin Liu, Jiaqi Yu, Cuili Wang
Summary: This study aims to evaluate the effectiveness of a theory-driven exercise intervention for frail older adults in Chinese communities and clarify its underlying mechanisms. The study will be conducted through a stepped-wedge cluster-randomized trial in six communities in a county in central China. The exercise intervention will be based on the integration of the Health Belief Model and the Theory of Planned Behaviour. The study is expected to provide an effective and practical mode for exercise interventions among frail older adults and contribute to existing evidence in this field.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Immunology
Elizabeth M. Irungu, Josephine Odoyo, Elizabeth Wamoni, Elizabeth A. Bukusi, Nelly R. Mugo, Kenneth Ngure, Jennifer F. Morton, Kenneth K. Mugwanya, Jared M. Baeten, Gabrielle O'Malley
Summary: Public HIV care clinics in Kenya made various adaptations to integrate PrEP delivery, such as initiating clients on PrEP without creatinine testing and providing two to three months of pills at a time. These adaptations helped reduce barriers for clients and staff and may facilitate the scale-up of PrEP delivery.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2021)
Article
Substance Abuse
Maja Weemes Grotting, Daniel Bergsvik, Ingeborg Rossow
Summary: This study aims to evaluate the effects of extending sales hours on Saturdays in Norwegian monopoly outlets, including the impact on alcohol sales and potential substitution effects. The study is designed as a stepped wedge cluster-randomized trial with a high power level for detecting causal effects of a relatively small policy change in alcohol sales.
Article
Mathematical & Computational Biology
Jessica Kasza, Rhys Bowden, Richard Hooper, Andrew B. Forbes
Summary: Batched stepped wedge designs allow for staggered cluster recruitment, providing greater flexibility compared to standard designs. This approach helps reduce delays before a trial can start, improving efficiency in testing interventions across clusters.
STATISTICS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Kelly M. Doran, Allison Torsiglieri, Stephanie Blaufarb, Patricia Hernandez, Emily Melnick, Lauren Velez, Charles M. Cleland, Charles Neighbors, Megan A. O'Grady, Donna Shelley
Summary: This is a protocol for a hybrid type 3 stepped-wedge cluster randomized controlled trial on overdose prevention practice implementation in permanent supportive housing (PSH). The study aims to evaluate the effectiveness and factors influencing implementation using various measures such as training, implementation support, and surveys. The findings from this research will have significant implications for overdose prevention, particularly in the homeless population.
IMPLEMENTATION SCIENCE
(2023)
Article
Medicine, General & Internal
Tobias N. Bonten, Sanne Marije Verkleij, Rianne M. J. J. van der Kleij, Karin Busch, Wilbert B. van den Hout, Niels H. Chavannes, Mattijs E. Numans
Summary: This study aims to evaluate the (cost-)effectiveness of implementing an integrated group-based lifestyle programme in primary care practices, identify effective intervention elements, and determine implementation determinants of an integrated group-based lifestyle intervention for patients with high cardiovascular risk.
Article
Public, Environmental & Occupational Health
Ingrid T. Katz, Kenneth Ngure, Kevin Kamolloh, Vallery Ogello, Moses Okombo, Nicholas B. Thuo, Esther Owino, Lindsey E. Garrison, Yeonsoo S. Lee, Maria F. Nardell, Chiemelie Anyacheblu, Elizabeth Bukusi, Nelly Mugo, Jared M. Baeten, Jessica E. Haberer
Summary: This study aimed to understand why young, high-risk women in Kenya chose not to enroll in a PrEP adherence trial. The findings suggest that social norms and moral beliefs are the main barriers preventing women from accepting PrEP. To increase PrEP uptake among young Kenyan women, approaches addressing social norms and de-medicalizing HIV prevention services are needed.
Article
Public, Environmental & Occupational Health
Vallery Ogello, Kenneth Ngure, Nicholas Thuo, Bridget Burns, Bernard Rono, Kevin Oware, Catherine Kiptiness, Nelly Mugo, Elizabeth Bukusi, Lindsey Garrison, Jared M. Baeten, Jessica E. Haberer
Summary: Qualitative methods were used to explore the experiences of trial participants with SMS reminders. Initially, the reminders were highly acceptable, but over time, concerns about privacy, self-efficacy, responsibility, and SMS fatigue emerged. Challenges such as phone loss, poor network, and lack of electricity were also reported.
Review
Public, Environmental & Occupational Health
Madeleine Goldstein, Moherndran Archary, Julian Adong, Jessica E. Haberer, Lisa M. Kuhns, Ann Kurth, Keshet Ronen, Marguerita Lightfoot, Irene Inwani, Grace John-Stewart, Robert Garofalo, Brian C. Zanoni
Summary: Adolescents and young adults in low to middle income countries have poorer outcomes in HIV prevention and care compared to other age groups. The use of mHealth interventions shows promise in addressing these disparities, but more large-scale randomized trials are needed.
Editorial Material
Medicine, General & Internal
Jessica E. Haberer, Yap Boum
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Immunology
Mary E. Tabatneck, Wei He, Gabriella S. Lamb, Mingwei Sun, Don Goldmann, Vishakha Sabharwal, Thomas J. Sandora, Jessica E. Haberer, Jeffrey I. Campbell
Summary: This retrospective cohort study analyzed 321 IGRA results, of which 308 were valid and 13 were invalid/indeterminate. The study found a significantly higher proportion of invalid/indeterminate results among immunocompromised patients compared to immunocompetent patients. Discordant results were more common in bacille Calmette-Guerin-vaccinated patients. IGRAs should be considered as a diagnostic method for tuberculosis infection in certain clinical scenarios for children under 2 years of age.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Editorial Material
Medicine, General & Internal
Suzanne Koven, Jessica E. Haberer, Deborah Gomez Kwolek
Summary: Residents who want to get pregnant often have few options to adjust their schedules without interrupting their careers. This situation highlights the need for both structural and cultural changes.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Lauren Jennings, Rebecca L. West, Nafisa Halim, Jeanette L. Kaiser, Marya Gwadz, William B. MacLeod, Allen L. Gifford, Jessica E. Haberer, Catherine Orrell, Lora L. Sabin
Summary: This study aims to use the multiphase optimization strategy (MOST) framework to determine the most effective combination of HIV adherence monitoring and support intervention components for implementation in resource-limited clinics in South Africa. The study will evaluate factors such as acceptability, feasibility, and cost-effectiveness, and validate the results through a randomized controlled trial. The findings of this study will be crucial for pragmatic adherence support to end the HIV epidemic.
Article
Infectious Diseases
Abubaker Ibrahim Elbur, Musie Ghebremichael, Deborah Konkle-Parker, Deborah L. Jones, Shelby Collins, Adaora A. Adimora, Michael F. Schneider, Mardge H. Cohen, Bani Tamraz, Michael Plankey, Tracey Wilson, Adebola Adedimeji, Jessica E. Haberer, Denise L. Jacobson
Summary: This study aimed to investigate the interrelationship between adherence to antiretroviral therapy (ART) and polypharmacy. The results showed no significant interrelationship between ART adherence and polypharmacy. Future research should consider using objective measures of adherence to examine the relationship between these two variables.
AIDS RESEARCH AND THERAPY
(2023)
Review
Immunology
Jessica E. Haberer, Andrew Mujugira, Kenneth H. Mayer
Summary: The effectiveness of HIV pre-exposure prophylaxis (PrEP) is hindered by barriers such as poor access, discrimination, stigma, and lack of understanding. Barriers to adherence and persistence include individual factors (such as depression) and community support. However, opportunities to improve PrEP adherence exist through innovative delivery systems, tailored interventions, and monitoring strategies. Person-centred approaches to service delivery are crucial for improving PrEP adherence and facilitating healthcare access.
Article
Immunology
Jose R. Castillo-Mancilla, Mary Morrow, Peter W. Hunt, Samuel R. Schnittman, Andrew N. Phillips, Jason Baker, Jessica E. Haberer, Maria Joao Janeiro, Filipa Aragao, Cal Cohen, Nicholas Musinguzi, Todd T. Brown, Matthias Cavassini, Tracy R. Glass, Sergio Serrano-Villar, Samantha Mawhinney, Mark Siedner
Summary: Incomplete antiretroviral therapy (ART) adherence has been linked to adverse outcomes in people with HIV. The impact of improving adherence on the risk of severe non-AIDS events (SNAEs) and death is unknown.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Health Care Sciences & Services
Edith K. Wakida, Celestino Obua, Jessica E. Haberer, Stephen J. Bartels
Summary: This study aims to understand the role and challenges of the district health management teams (DHMT) in mental health integration in Uganda, and propose solutions for improvement. The findings suggest that DHMT members lack knowledge and data on mental health integration, and recommend training, standard outcome reports, and practical tools for better support and supervision.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Public, Environmental & Occupational Health
Beatriz Grinsztejn, Thiago Silva Torres, Brenda Hoagland, Emilia Moreira Jalil, Ronaldo Ismerio Moreira, Gabrielle O'Malley, Starley B. Shade, Marcos R. Benedetti, Julio Moreira, Keila Simpson, Maria Cristina Pimenta, Valdilea Goncalves Veloso, ImPrEP CAB Brasil Study Team
Summary: ImPrEP CAB Brasil is an implementation study in Brazil aiming to evaluate the effectiveness of long-acting injectable cabotegravir (CAB-LA) for preexposure prophylaxis (PrEP) and identify effective implementation approaches, especially among young sexual and gender minorities (SGMs). The study includes formative work, qualitative assessments, and clinical steps 1 to 4. The outcomes of interest include PrEP acceptability, choice, effectiveness, implementation, and feasibility. This study is important for designing programmatic strategies for PrEP programs and reducing HIV incidence among SGMs in Brazil and other countries in the Global South.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Public, Environmental & Occupational Health
Nicholas Musinguzi, Kenneth Ngure, Elizabeth A. Bukusi, Nelly R. Mugo, Jared M. Baeten, Peter L. Anderson, Jessica E. Haberer
Summary: Understanding PrEP adherence is crucial for HIV prevention strategies, but measuring adherence is challenging. In a two-year study, various adherence measures were compared among high-risk Kenyan women. The study found moderate concordance between electronic adherence monitoring (EAM) and tenofovir diphosphate (TFV-DP) levels in blood spots. The correlation between EAM and self-reported measures was low, while the correlation within self-reported measures was moderate. These findings suggest the usefulness of both TFV-DP and EAM as PrEP adherence tools.
Meeting Abstract
Obstetrics & Gynecology
Adeline A. Boatin, Paola Del Cueto, Lisa M. Bebell, Henry Mark Mark Lugobe, Kenia Martinez, Sudi Mohamed, Blair Wylie, Godfrey R. Mugengyi, Nicholas Musinguzi, Joshua Metlay, Bethany Hedt-Gauthier, Jessica Haberer, Joseph Ngonzi
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Health Care Sciences & Services
Joseph Ngonzi, Lisa Bebell, Adline Boatin, Aspihas Owaraganise, Leevan Tiibajuka, Yarine Fajardo, Henry Lugobe, Blair Wylie, Yves Jacquemyn, Celestino Obua, Jessica Haberer, Jean-Pierre Van Geertruyden
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
(2023)