Article
Orthopedics
Adele Changoor, R. Peter Suderman, Ibrahim Alshaygy, Ariel Fuhrmann, Margarete K. Akens, Oleg Safir, Marc D. Grynpas, Paul R. T. Kuzyk
Summary: Two commercially available porous coatings, Gription and Porocoat, were compared for the first time in a challenging intra-articular, weight-bearing, ovine model. The study found that Gription coating provided superior fixation strength and bone ingrowth compared to Porocoat.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Zhengqing Zhu, Xin Li, Youbin Li, Liwei Zhu, Chenyi Zhu, Zhenjia Che, Lanfeng Huang
Summary: The study evaluated a porous titanium implant prepared using EBM technology with a composite scaffold containing temperature-sensitive collagen and rhBMP9 to enhance osteogenesis in rabbit femoral defects. In vitro experiments demonstrated cell proliferation, release of temperature-sensitive collagen to rhBMP9, and osteogenesis-inducing effect on bone marrow mesenchymal stem cells, while in vivo evaluation showed good biocompatibility and enhanced osteogenesis around the porous scaffolds.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Yi-Tong Yao, Yue Yang, Qi Ye, Shan-Shan Cao, Xin-Ping Zhang, Ke Zhao, Yutao Jian
Summary: The study fabricated six groups of porous Ti samples with different porosities and pore sizes using powder metallurgy process. It was found that porous Ti with high porosity and small pore size facilitated protein absorption, cell differentiation, and calcification. The mechanical properties of porous Ti with a porosity of 53.3 +/- 1.2% and an average pore size of 191.6 +/- 3.7 mu m were suitable for osseointegration as dental implants.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Changgui Zhang, Yangjing Lin, Liu Yang, Xiaojun Duan
Summary: The use of 3D printing technology to assist supramalleolar osteotomy in the treatment of ankle osteoarthritis can reduce the operation time, intraoperative bleeding, and frequency of fluoroscopy. Personalized 3D printed osteotomy guides and models can aid in the accurate correction of ankle deformities, restore limb alignment, and improve biomechanical status.
Article
Biotechnology & Applied Microbiology
Jian-Tong Cui, Xin-Yuan Wang, Xiao-Dan Mu, Meng Huang, Ya-Di Wang, Qiang Luo, Hui-Xia He
Summary: This study establishes a sustainably releasing system of exosomes-fibrin combinate loaded on tantalum-coating titanium implants. The system has potential effects on osseointegration between tantalum coating titanium implants and the surrounding bone tissue. The study demonstrates that the exosome sustained-release system with fibrin loading on the tantalum coating successfully promotes adhesion, proliferation, and osteogenic differentiation of BMSCs, and significantly enhances the osseointegrative capacity of the implants in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Juyang Jiao, Qimin Hong, Dachen Zhang, Minqi Wang, Haozheng Tang, Jingzhou Yang, Xinhua Qu, Bing Yue
Summary: Porous tantalum scaffolds with three different porosities (60%, 70%, and 80%) were prepared using laser powder bed fusing technique to investigate the effects on the adhesion, proliferation, and osteogenic differentiation of rat mesenchymal stem cells in vitro. The in vivo bone ingrowth and osseointegration effects of each scaffold were evaluated in a rat femoral bone defect model. The results showed that scaffolds with 70% and 80% porosity exhibited better osteogenic proliferation and differentiation capacity, as well as bone ingrowth, suggesting that the 3D printed trabecular tantalum scaffold with 70% porosity could be the optimal choice for implant design.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Joseph Deering, Dalia Mahmoud, Elyse Rier, Yujing Lin, Anna Cecilia do Nascimento Pereira, Silvia Titotto, Qiyin Fang, Gregory R. Wohl, Feilong Deng, Kathryn Grandfield, Mohamed A. Elbestawi, Jianyu Chen
Summary: This study utilized selective laser melting to produce scaffolds with different pore sizes, and evaluated their cell proliferation and bone deposition through in vitro and in vivo experiments. The results showed that the scaffold with 300 mu m pores had better bone deposition compared to the functionally graded specimens, and the porous structure of the scaffold guided the direction of bone growth. Further in vivo experiments and parameter optimization are needed to predict bone apposition.
BIOMATERIALS ADVANCES
(2023)
Article
Engineering, Manufacturing
Yu-Tzu Wang, Chun-Ming Chang, Pei-Hsin Liu, Chun-Li Lin
Summary: Porous titanium implant surfaces fabricated using additive manufacturing can enhance bone-implant stability. A new lattice type implant was designed to improve bone ingrowth efficiency and interfacial bonded strength. The experiment showed that the new lattice implant had significantly higher bonded strength compared to the traditional implant.
ADDITIVE MANUFACTURING
(2023)
Article
Nanoscience & Nanotechnology
Zhiyi Zhang, Yuzhou Li, Ping He, Fengyi Liu, Lingjie Li, He Zhang, Ping Ji, Sheng Yang
Summary: This study aimed to fabricate a hierarchical tantalum scaffold mimicking natural bone structure to enhance osseointegration. Results demonstrated that the hierarchical tantalum structure could improve biocompatibility, promote bone cell proliferation, enhance transcription of bone formation genes, and facilitate early bone-scaffold integration.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Biomedical
Xinglong Hu, Shiqi Mei, Fan Wang, Jun Qian, Dong Xie, Jun Zhao, Lili Yang, Zhaoying Wu, Jie Wei
Summary: The implantable composites of PEKK/Ta, especially PT40 with higher Ta content, showed improved surface performance and biological activity, as well as mechanical properties close to human cortical bone.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Biomaterials
Xueying Wang, Dachen Zhang, Haitao Peng, Jingzhou Yang, Yan Li, Jianxia Xu
Summary: This study investigated the effects of pore structure characteristics on osteoblast behaviors and bone regeneration using 3D-printed porous tantalum scaffolds. The results showed that a bionic trabecular structure with both large and small pores facilitated cell permeation, proliferation, and differentiation, and had the best potential for critical bone defect repair.
BIOMATERIALS ADVANCES
(2023)
Article
Biophysics
Rongxin Wan, Xiaojuan Wang, Li Lei, Guoying Hu, Huiqing Tang, Hanqing Gu
Summary: Polyetheretherketone (PEEK) surface was modified with Ta/Cu ion co-implantation using plasma immersion ion-implantation technology. The modified surface showed improved antimicrobial activity and promoted osseointegration. Ta ion-treated surface enhanced the adhesion, proliferation, and osteogenic differentiation of BMSCs, while Cu ion-treated surface inhibited bacterial adhesion and proliferation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biophysics
Julia Augustin, Franziska Feichtner, Anja-Christina Waselau, Stefan Julmi, Christian Klose, Peter Wriggers, Hans Juergen Maier, Andrea Meyer-Lindenberg
Summary: This study compares the performance of two different pore-sized magnesium alloy scaffolds and finds that the larger pore size scaffold has better osseointegration and biocompatibility.
JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Biomedical
Hu Qian, Ting Lei, Long Hua, Yu Zhang, Dongyu Wang, Jiangyu Nan, Wenbin Liu, Yan Sun, Yihe Hu, Pengfei Lei
Summary: In this study, a novel scaffold composed of gelatin methacryloyl (GelMA) hydrogel and poly(lactic co-glycolic acid) (PLGA) microspheres encapsulating vancomycin (Van) was developed for one-stage repair of infected bone defects (IBDs). The scaffold exhibited sustained release of Van for over 2 weeks and demonstrated good biocompatibility, bacteriostasis, and osteointegration properties, showing great potential for clinical application. The construction of this scaffold provides new insights into the development of orthopaedic implants and offers a novel approach for the treatment of IBDs.
BIOACTIVE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Bolun Liu, Huizhi Wang, Ningze Zhang, Min Zhang, Cheng-Kung Cheng
Summary: Cementless femoral stems can lead to stress shielding and implant loosening, but using porous structures and lower stiffness can reduce this effect and improve long-term stability. Advances in additive manufacturing have enabled the fabrication of femoral stems with internal porous lattices.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hany Emam, Daniel Leach, Zongyang Sun, Boon Ching Tee, Berfin Karatas, Do-Gyoon Kim, Courtney Jatana
JOURNAL OF ORAL IMPLANTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Samer A. Faraj, Ahmad Kutkut, Robert C. Taylor, Alejandro Villasante-Tezanos, Sarandeep S. Huja, Dolphus R. Dawson, Nehal Almehmadi, Mohanad Al-Sabbagh
Summary: The study compared the use of human amnion-chorion membrane with collagen membrane in exposed-barrier ridge preservation technique for implant placement. Intentional membrane exposure did not compromise ridge dimensions or bone vitality, and there was no significant difference in bone formation between the two membrane types.
JOURNAL OF ORAL IMPLANTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Soorya Srinivasan, Boon Ching Tee, Amy Wang, Anita Gohel, Do-Gyoon Kim, Toru Deguchi, Zongyang Sun
Summary: This study investigates the reliability and accuracy of CBCT diagnosis of contact between TAD and tooth root, revealing good reliability but low accuracy, with a likelihood of high false-positive diagnoses.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2021)
Review
Endocrinology & Metabolism
Fazal-Ur-Rehman Bhatti, Anastasios Karydis, Beth S. Lee, Toru Deguchi, Do-Gyoon Kim, Hongsik Cho
Summary: This review discusses the prevalence of posttraumatic osteoarthritis (PTOA) in load-bearing joints, especially the knee joint and temporomandibular joint (TMJ), and the potential of using mouse models to study early PTOA. While knee joint PTOA has been extensively studied, early diagnostic methods for TMJ PTOA are still lacking. The review also highlights the use of near-infrared imaging for early diagnosis of TMJ-PTOA.
CURRENT OSTEOPOROSIS REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hannah B. Lucas, Ian McKnight, Regan Raines, Abdullah Hijazi, Christoph Hart, Chan Lee, Do-Gyoon Kim, Wei Li, Peter H. U. Lee, Joon W. Shim
Summary: In cardiovascular diseases, 64 genetic loci involving genetic mutations matched with specific factors related to monogenic hypertension, resulting in a matching rate of 81%. However, this high matching rate was not observed in genes associated with essential hypertension, thoracic aortic aneurysm, and congenital heart disease, with matching rates of 53%, 70%, and 75% respectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Juyeon Cho, Jie Liu, Esraa A. Bukhari, Fengyuan Zheng, Do-Gyoon Kim, Damian J. Lee
Summary: This in vitro study compared post space volume changes after removal of glass fiber posts in endodontically treated teeth using Er,Cr:YSGG laser and conventional ultrasonic method. Results showed that there was no significant difference in post space volume changes between the two methods, but less dentin loss was observed in the coronal portion of the post space when laser was used for removal. Both methods were effective in increasing post space volume following removal.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2022)
Article
Biophysics
Kyle A. Bodnyk, Do-Gyoon Kim, Xueliang Pan, Richard T. Hart
Summary: Low-magnitude mechanical stimulation (LMMS) has shown short-term benefits for skeletal health and could be used to increase long-term mechanical integrity of bone. This study aimed to investigate the long-term effects of whole body vibration therapy on the elastic and viscoelastic properties of bone. Results showed that LMMS led to an increase in bending stiffness and damping, tan delta, and loss stiffness. Finite element models also indicated decreased stress in the mid-diaphyseal region. These findings suggest that LMMS has the potential to improve bone health over the long term.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Dentistry, Oral Surgery & Medicine
Keiichiro Watanabe, Bobby Mitchell, Takuma Sakamaki, Yuzo Hirai, Do-Gyoon Kim, Toru Deguchi, Masakazu Suzuki, Kanji Ueda, Eiji Tanaka
Summary: This study examined the mechanical stability of orthodontic miniscrews with different thread shapes in bone. The results showed that miniscrews with a novel thread shape had higher initial stability in thinner artificial bone. Therefore, it is important to consider the thickness of the cortical bone when selecting the type of screw thread.
JOURNAL OF DENTAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Keiichiro Watanabe, Sanghee Lee, Damian Lee, Fengyuan Zheng, Hee-Moon Kyung, Do-Gyoon Kim, Toru Deguchi
Summary: This study compared the effects of different insertion techniques on mechanical and clinical parameters of two types of miniscrews. The results showed that self-drilling produced higher Periotest values at the time of placement and after 4 weeks. Drilling, on the other hand, avoided root contact and enhanced the primary stability, resulting in lower Periotest values.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Chemistry, Multidisciplinary
Eun-Sang Moon, Seora Kim, Nathan Kim, Minjoung Jang, Toru Deguchi, Fengyuan Zheng, Damian J. Lee, Do-Gyoon Kim
Summary: By analyzing 136 clinical CBCT images, this study found that females had significantly higher gray level parameter values of C2 and C3 compared to males across all age groups. Additionally, the Mean and Low5 parameter values of C2 and C3 in the female 60-age group were significantly lower than those in the female 40- and 50-age groups, likely due to postmenopausal demineralization of bone. These findings suggest that dental CBCT can detect age-dependent changes of cervical vertebral BMD.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
K. Nagasaki, M. B. Chavez, A. Nagasaki, J. M. Taylor, M. H. Tan, M. Ma, E. Ralston, M. E. Thew, D-G Kim, M. J. Somerman, B. L. Foster
Summary: Bone sialoprotein plays an important role in periodontal development and mineralization, particularly through its RGD domain.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jie Liu, Keiichiro Watanabe, Shareef M. Dabdoub, Beth S. Lee, Do-Gyoon Kim
Summary: One-third of postmenopausal women experience osteoporotic bone fractures, but jaw bone fractures are rare. The mechanisms behind the differences between jaw bone and limb bone during postmenopause are largely unknown. This study examined the effects of estrogen deficiency on bone quantity and quality, and found that mandibular bone marrow stem cells had greater differentiation capacity than femur bone marrow stem cells.
Article
Dentistry, Oral Surgery & Medicine
Paul J. Kim, Zachary Skabelund, Sonya Kalim, Christine H. Lee, Nathan Kim, Kristen Nguyen, Hany Emam, Lisa Knobloch, Toru Deguchi, Minji Kim, Do-Gyoon Kim
Summary: This study investigates the association between bone mineral density distribution in the mandibular condyle and facial morphology with temporomandibular joint osteoarthritis (TMJ OA) using clinical cone beam computed tomography (CBCT) images. The results show that female participants had higher values in certain parameters compared to the male participants.
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Fazal-Ur-Rehman Bhatti, Yong-Hoon Jeong, Do-Gyoon Kim, Ae-Kyung Yi, David D. Brand, Karen A. Hasty, Hongsik Cho
Summary: The pathophysiology of post-traumatic arthritis (PTOA) was investigated using mouse models. The study found significant biochemical, biomechanical, and pain-related behavioral changes in loaded knee joints compared to non-loaded control joints. These findings provide important insights for studying PTOA.
Article
Dentistry, Oral Surgery & Medicine
Damian Jae-whan Lee, Eun-sang Moon, Kenneth Stephen, Jie Liu, Do-Gyoon Kim
Summary: This pilot study aimed to investigate the effect of dental implantation on bone mineral density (BMD) distribution by comparing dentate, edentulous, and edentulous patients with implants. The results showed that edentulous patients with implants had higher BMD distribution parameters compared to edentulous patients, and the mean, HSD, and High(5) values of BMD significantly increased after receiving implants. Therefore, dental implants can promote oral bone mineralization in edentulous patients.
JOURNAL OF ADVANCED PROSTHODONTICS
(2022)
