Optimizing NKT cell ligands as vaccine adjuvants

In-vivostimulation of macaque natural killer T cells with α-galactosylceramide

(2013) C. S. Fernandez et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology

(2013) Fatima Tahiri et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells

(2013) You Jeong Lee et al.   NATURE IMMUNOLOGY

A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates

(2013) Neal N. Padte et al.   PLoS One

Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells

(2013) X. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides

(2013) L. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

(2013) R. V. V. Tatituri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma

(2012) J. Richter et al.   BLOOD

CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells

(2012) Joseph P. Sanderson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

New ways to turn on NKT cells: Figure 1.

(2011) Dale Ian Godfrey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Rapid Fluorescence-Based Assay for Classification of iNKT Cell Activating Glycolipids

(2011) Pooja Arora et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

(2011) Patrick J Brennan et al.   NATURE IMMUNOLOGY

V 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen

(2011) O. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NKT Cells in Sepsis

(2010) Briana Leung et al.   Clinical & Developmental Immunology

Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant

(2010) Neal N. Padte et al.   CLINICAL IMMUNOLOGY

Induction of Th1-biased cytokine production by  -carba-GalCer, a neoglycolipid ligand for NKT cells

(2010) T. Tashiro et al.   INTERNATIONAL IMMUNOLOGY

Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant

(2010) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA vaccine with α-galactosylceramide at prime phase enhances anti-tumor immunity after boosting with antigen-expressing dendritic cells

(2010) Daejin Kim et al.   VACCINE

An α-GalCer analogue with branched acyl chain enhances protective immune responses in a nasal influenza vaccine

(2010) Yoon-Sook Lee et al.   VACCINE

Combination therapy ofin vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma

(2009) Naoki Kunii et al.   CANCER SCIENCE

Natural Killer T Cells and Autoimmune Disease

(2009) Lan Wu et al.   CURRENT MOLECULAR MEDICINE

Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation

(2009) Jin S. Im et al.   IMMUNITY

Incorporation of NKT Cell-Activating Glycolipids Enhances Immunogenicity and Vaccine Efficacy of Mycobacterium bovis Bacillus Calmette-Guerin

(2009) M. M. Venkataswamy et al.   JOURNAL OF IMMUNOLOGY

T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC

(2009) L. J. Carreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid and glycolipid antigens of CD1d-restricted natural killer T cells

(2009) Manjunatha M. Venkataswamy et al.   SEMINARS IN IMMUNOLOGY

Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy

(2009) Prakash Thapa et al.   VACCINE

Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine

(2009) Sarah A. Kopecky-Bromberg et al.   VACCINE

Murine NKT cells produce Th17 cytokine interleukin-22

(2008) Megumi Goto et al.   CELLULAR IMMUNOLOGY

Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

(2008) Jin S. Im et al.   CLINICAL IMMUNOLOGY

Glycolipid-activated NKT cells support the induction of persistent plasma cell responses and antibody titers

(2008) T. Scott Devera et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanism of NKT cell activation by intranasal coadministration of α-galactosylceramide, which can induce cross-protection against influenza viruses

(2008) H Kamijuku et al.   Mucosal Immunology

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population

(2008) J. M. Coquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, α-galactosylceramide

(2008) Yaoxing Huang et al.   VACCINE

Humans Lack iGb3 Due to the Absence of Functional iGb3-Synthase: Implications for NKT Cell Development and Transplantation

(2008) Dale Christiansen et al.   PLOS BIOLOGY