Article
Allergy
Alexandra Chabot, Claudia Lang, Thomas M. Kundig, Peter Schmid-Grendelmeier, Pal Johansen
Summary: AIT can be used to treat IgE-mediated bee venom allergy, with SCIT being time and cost intensive. ILIT offers a potential reduction in treatment costs due to fewer injections and shorter therapy duration. This study shows a potential two-fold reduction in treatment costs when switching from SCIT to ILIT for bee venom allergy.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Wenlong Liu, Qingxiang Zeng, Chunhui He, Rongshan Chen, Yiquan Tang, Shengbao Yan, Xi Luo, Renzhong Luo
Summary: The study compared the efficacy, safety, and compliance of SCIT and SLIT in children with allergic rhinitis. Results indicated that SCIT was more effective than SLIT to a certain degree but had higher occurrence of adverse events. Individuals can choose the appropriate AIT route based on their specific conditions.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Claire Monge, Camille Ayad, Anne-Lise Paris, Renaud Rovera, Evelyne Colomb, Bernard Verrier
Summary: This study developed a mucoadhesive patch that can effectively deliver viral proteins to the epithelium of the sublingual mucosa through mucosal administration. By encapsulating adjuvants 3M-052 and mifamurtide in nanoparticles, targeted activation of TLR-7/8 and NOD2 was achieved, showing a cytokine/chemokine signature similar to the cholera toxin during the activation of innate immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Jin Youp Kim, Myoung-Jin Jang, Dong-Young Kim, Seok-Won Park, Doo Hee Han
Summary: This study compared the efficacy of SLIT drops, SLIT tablets, and SCIT in patients with perennial allergic rhinitis through network analysis. The results demonstrated that all immunotherapy modalities significantly reduced symptom and medication scores, with SCIT possibly being more effective in controlling symptoms compared to SLIT drops or tablets.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Letter
Public, Environmental & Occupational Health
Luis Furuya-Kanamori, Deborah J. Mills, Colleen L. Lau
Summary: Research has shown that administering smaller doses of JE vaccine intradermally is as effective as standard doses given subcutaneously, potentially increasing vaccination uptake due to the cheaper and still effective method of administration.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Immunology
Tiffany Kirkaldy Spaanager Sztuk, Neil Marcus Rigby, Lasse Norskov-Nielsen, Stef J. Koppelman, Ana Isabel Sancho, Niels-Peter Hell Knudsen, Justin Marsh, Philip Johnson, Shashank Gupta, Alan Robert Mackie, Jeppe Madura Larsen, Katrine Lindholm Bogh
Summary: This study compared the preventive effect of allergen-specific immunotherapy through different routes of peanut allergen delivery in rats. Results showed that high dose oral and sublingual administration, as well as high and medium dose intragastric administration, prevented peanut allergy. Therefore, the route of allergen delivery plays a significant role in preventing peanut allergy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Food Science & Technology
Erika Gamulin, Sanja Mateljak Lukacevic, Beata Halassy, Tihana Kurtovic
Summary: Envenomations from animal bites and stings are a significant public health issue. While there is no standardized protocol, parenteral administration of polyclonal antivenoms is the main treatment for snakebites. It is believed that intramuscular administration is not very effective, and intravenous administration is preferred for better therapeutic activity. Recent research has shown that neutralization in the lymphatic system also plays a role in clinical outcomes, as it is another route through which venom is absorbed.
Article
Allergy
Mohamed H. Shamji, David Larson, Aarif Eifan, Guy W. Scadding, Tielin Qin, Kaitie Lawson, Michelle L. Sever, Ellen Macfarlane, Janice A. Layhadi, Peter A. Wurtzen, Rebecca Parkin, Srinath Sanda, Kristina M. Harris, Gerald T. Nepom, Alkis Togias, Stephen R. Durham
Summary: The study compared allergic responses in nasal and systemic fluids during sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) for grass pollen allergy, suggesting key differences in immunological mechanisms between the two treatments.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Shaobing Xie, Ruohao Fan, Qingping Tang, Xiao Cai, Hua Zhang, Fengjun Wang, Shumin Xie, Kelei Gao, Junyi Zhang, Zhihai Xie, Weihong Jiang
Summary: This study identifies IL-4, eotaxin, and IFN-γ as potential biomarkers for predicting the efficacy of subcutaneous immunotherapy in children with house dust mite-induced allergic rhinitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Zao Ji, Feifei Jiang
Summary: This study systematically evaluated the clinical efficacy and safety of sublingual immunotherapy for allergic rhinitis. The findings showed that sublingual immunotherapy has better efficacy and safety compared to traditional medicine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sara Puente-Marin, Fabricia Dietrich, Peter Achenbach, Hugo Barcenilla, Johnny Ludvigsson, Rosaura Casas
Summary: GAD-alum injections into lymph nodes had a positive effect on T1D patients with DR3DQ2 haplotype, showing better preservation of C-peptide. Patients receiving GAD-alum had higher levels of GADA, GADA subclasses, GAD(65)-induced proliferation, and cytokine secretion compared to the placebo group. Good responders with DR3DQ2 haplotype had a distinct cellular immune response to GAD-alum injections, associated with increased IL13 secretion and proliferation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Masaaki Hamada, Keigo Saeki, Ichiro Tanaka
Summary: This study compared the effectiveness and safety of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) for allergic rhinitis. The results showed that the HDM SCIT group had an earlier therapeutic effect and a lower discontinuation rate compared to the HDM SLIT group, although more severe systemic reactions were observed during the maintenance phase.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Nanki Hura, Sophia Song, Rebecca J. Kamil, Gerdline Pierre, Sandra Y. Lin
Summary: Sublingual immunotherapy (SLIT) is an effective alternative to subcutaneous immunotherapy (SCIT) with a better safety profile, but patient completion still relies on factors such as clinic visits and dosage adjustment. Patients younger than 12 with asthma are more likely to complete therapy. Increasing clinic visits and addressing concerns about therapy efficacy may improve patient completion rates.
Article
Allergy
Marie-Lee Simard, Natalija Novak, Jean-Philippe Drolet, Marie-Claude Joly, Hendrik Nolte, Eike Wuestenberg, Remi Gagnon
Summary: This study evaluated the tolerability of vestibular administration route of AIT-tablets compared with the sublingual route in adult subjects with AR/C. The results showed that the frequencies of subjects experiencing severe TRAEs, at least one TRAE, and discontinuations due to AEs at the initiation of AIT-tablets were numerically higher with vestibular administration than sublingual administration. Sublingual administration should remain the standard of care for subjects treated with AIT-tablets for AR/C.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Immunology
Franco Frati, Noemi De Beni, Laura Marastoni, Enrico Compalati, Giorgio Ciprandi
Summary: This study evaluated the safety of allergen-specific immunotherapy using carbamylated monomeric allergoids and found that adverse reactions were extremely rare. Both sublingual and subcutaneous routes of administration were shown to have excellent safety profiles in children.
Article
Allergy
S. Manti, F. Galdo, G. F. Parisi, M. Napolitano, F. Decimo, S. Leonardi, M. Miraglia Del Giudice
Summary: The study found that preschool children born with extremely low birth weight show an increase in impedance and resistance of small airways. There were no significant differences in lung function and bronchial reversibility between the BPD group and non-BPD group. However, factors such as gestational age, duration of oxygen therapy, and sepsis significantly affected respiratory function in the BPD group.
Article
Medicine, General & Internal
D. Araiza-Garaygordobil, C. Montalto, P. Martinez-Amezcua, A. Cabello-Lopez, R. Gopar-Nieto, R. Alabrese, A. Almaghraby, S. Catoya-Villa, M. Chacon-Diaz, C. C. Kaufmann, M. Corbi-Pascual, P. Deharo, M. El-Tahlawi, A. Elgohari-Abdelwahab, F. Guerra, M. Jarakovic, E. Martinez-Gomez, L. Moderato, S. Montero, P. Morejon-Barragan, A. M. Omar, P. Jorge-Perez, P. Przybylo, E. Selim, U. Y. Sinan, M. Stratinaki, O. Tica, M. Trepa, A. Uribarri, J. Uzokov, K. Wilk, K. Czerwinska-Jelonkiewicz, A. Sionis, M. Gierlotka, S. Leonardi, K. A. Krychtiuk, G. Tavazzi
Summary: The study found a significant decrease in the rate of ACS hospitalizations, an increase in total ischemic time, and a higher rate of mechanical complications associated with the COVID-19 pandemic on an international scale.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2021)
Editorial Material
Immunology
Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Gian Luigi Marseglia, Amelia Licari, Salvatore Leonardi
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Giuseppe Fabio Parisi, Giuseppe Carota, Carlo Castruccio Castracani, Mariarita Spampinato, Sara Manti, Maria Papale, Michelino Di Rosa, Ignazio Barbagallo, Salvatore Leonardi
Summary: In recent years, there has been a growing scientific interest in nutraceuticals, especially in their potential antiviral properties, particularly within the pediatric population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Enza Mule, Donatella Aloisio, Novella Rotolo, Salvatore Leonardi
Summary: Research suggests that focusing on endothelial dysfunction rather than respiratory disease in COVID-19 infection could be key in identifying therapeutic methods that stabilize the endothelium instead of the lungs.
MEDICAL HYPOTHESES
(2021)
Article
Otorhinolaryngology
Giuseppe Fabio Parisi, Sara Manti, Maria Papale, Melania Amato, Amelia Licari, Gian Luigi Marseglia, Salvatore Leonardi
Summary: The study demonstrates that sublingual immunotherapy (SLIT) effectively improves symptoms of allergic rhinitis in children, especially after 6 months of treatment. By measuring nasal nitric oxide (nNO) and nasal cytology, it can predict the efficacy of SLIT treatment.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Article
Infectious Diseases
Carla Colombo, Marco Cipolli, Valeria Dacco, Paola Medino, Federico Alghisi, Maura Ambroni, Raffaele Badolato, Fiorella Battistini, Elisabetta Bignamini, Rosaria Casciaro, Fabiana Ciciriello, Mirella Collura, Isabella Comello, Michela Francalanci, Francesca Ficili, Anna Folino, Salvatore Leonardi, Giuseppina Leonetti, Maria Cristina Lucanto, Francesca Lucca, Massimo Maschio, Valeria Mencarini, Barbara Messore, Giovanna Pisi, Giovanna Pizzamiglio, Piercarlo Poli, Valeria Raia, Luca Riberi, Mirco Ros, Novella Rotolo, Angela Sepe, Giovanni Taccetti, Pamela Vitullo, Gianfranco Alicandro
Summary: This study aimed to describe the clinical course of COVID-19 in cystic fibrosis patients and identify risk factors for severe COVID-19. The study found that certain clinical features were associated with an increased risk of COVID-19 hospitalization.
Article
Allergy
Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Gian Luigi Marseglia, Amelia Licari, Salvatore Leonardi
Summary: Type 2 inflammation is recognized as a critical contributor to cystic fibrosis, and understanding its pathways can help identify targets for treating inflammation and fibrosis in patients with CF.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Oncology
Lucia Spicuzza, Emanuela Cannata, Lisa Angileri, Marialuisa Giuffrida, Giovanna Russo, Andrea Di Cataldo, Nunzio Crimi
Summary: The study found that in a group of young adults who survived common pediatric malignancies, most patients had preserved lung function with only a small percentage showing mild abnormalities.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Cristina Russo, Maria Stella Valle, Antonino Casabona, Lucia Spicuzza, Gianluca Sambataro, Lucia Malaguarnera
Summary: Skeletal muscle dysfunction is often associated with COPD, which is characterized by chronic inflammation and oxidative stress. Vitamin D deficiency also affects oxidative stress and mitochondrial function, impacting muscle function in COPD patients.
Review
Biochemistry & Molecular Biology
Cristina Russo, Valeria Colaianni, Giuseppe Ielo, Maria Stella Valle, Lucia Spicuzza, Lucia Malaguarnera
Summary: This review highlights the relationship between lung microbiota and chronic obstructive pulmonary disease (COPD). Inflammation, dysbiosis, and imbalance in the immune system may contribute to the development of lung diseases. Interventions targeting lung microbiota could potentially improve these conditions.
Article
Public, Environmental & Occupational Health
Lucia Spicuzza, Raffaele Campisi, Stefano Alia, Simone Prestifilippo, Maria Luisa Giuffrida, Lisa Angileri, Nicola Ciancio, Carlo Vancheri
Summary: The study found that at 4 months follow-up, women recovered from COVID-19 pneumonia are more likely to exhibit reduced alveolar diffusion capacity and exercise tolerance than men, despite a similar severity of the acute disease.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Public, Environmental & Occupational Health
D. Ponticelli, L. Losa, D. Campagna, R. Magliuolo, A. Vitale, D. Cacciapuoti, A. Zampella, L. Alleanza, B. Schiavone, L. Spicuzza, P. Ferrara
Summary: This research aimed to investigate the possible association between smoking habits and the incidence of adverse effects (AEs) after mRNA COVID-19 vaccine. A sample of Italian healthcare workers was longitudinally observed, and the occurrence of AEs after vaccination was evaluated. The study found a correlation between smoking habits and some adverse reactions after COVID-19 vaccination.
Article
Health Care Sciences & Services
Lucia Spicuzza, Salvatore Mancuso, Raffaele Campisi, Carlo Vancheri
Summary: The COVID-19 pandemic has had a remarkable impact on the sleep quality and mental health of patients with obstructive sleep apnea (OSA). The reported sleep disturbance rate in these patients is one of the highest documented so far. There is a close link between perceived sleep quality and psychological distress caused by the pandemic.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2022)
Letter
Pediatrics
Annarita Bongiovanni, Massimo Spina, Maria Papale, Ilaria Brambilla, Amelia Licari, Giuseppe F. Parisi, Salvatore Leonardi
MINERVA PEDIATRICS
(2021)
Review
Immunology
Xiangye Zhao, Kewei Ma, Xiaobo Ma, Xu Wang, Chao Sun, Shi Qiu, Ye Guo, Zhiguang Yang, Yunpeng Liu, Yinghui Xu
Summary: Immunotherapy may lead to pseudoprogression, where tumors initially grow but shrink with continued treatment. This article reports a case of pseudoprogression in a lung cancer patient receiving immunotherapy, and reviews the mechanisms, clinical manifestations, and prognostic indicators of pseudoprogression.
Article
Immunology
Ling-zhijie Kong, Ying Zheng, Kaichun Li
Summary: Treatment options for metastatic colorectal cancer are limited after second-line chemotherapy failure. In this case report, a 59-year-old male patient achieved remarkable response to fruquintinib and toripalimab combination therapy after multiple lines of chemotherapy failed. The patient had partial response within 3 months and complete response of pulmonary masses within 12 months. The combination of fruquintinib and PD-1 inhibitors improves the prognosis of metastatic colorectal cancer, with a progression-free survival of over 17 months.
