Journal
IMMUNOTHERAPY
Volume 4, Issue 3, Pages 283-290Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/IMT.12.3
Keywords
cytotoxic T lymphocyte; dendritic cell; immune-specific response; immunotherapy; intratumoral; neoadjuvant; radiation therapy; soft tissue sarcoma
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Funding
- NCI NIH HHS [P30 CA076292] Funding Source: Medline
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Soft tissue sarcomas are rare neoplasms, with approximately 9000 new cases in the USA every year. Unfortunately, during the past two decades, there has been little progress in the treatment of metastatic soft tissue sarcomas beyond the standard approaches of surgery, chemotherapy and radiation. Immunotherapy is a modality complementary to conventional therapy. It is appealing because functional antitumor activity could effect both local regional and systemic disease, and act over a prolonged period of time. In this report, we review immunotherapeutic investigative strategies that are being developed, including several tumor vaccine, antigen vaccine and dendritic cell vaccine strategies.
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