Novel routes for allergen immunotherapy: safety, efficacy and mode of action

Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF -Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis

(2014) M.-L. Chen et al.   JOURNAL OF IMMUNOLOGY

B Lymphocytes Promote Expansion of Regulatory T Cells in Oral Tolerance: Powerful Induction by Antigen Coupled to Cholera Toxin B Subunit

(2014) J.-B. Sun et al.   JOURNAL OF IMMUNOLOGY

Epicutaneous allergen administration: is this the future of allergen-specific immunotherapy?

(2011) G. Senti et al.   ALLERGY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

Adjuvants and Vector Systems for Allergy Vaccines

(2011) Philippe Moingeon et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response

(2011) Pooja Varshney et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epicutaneous Immunotherapy Results in Rapid Allergen Uptake by Dendritic Cells through Intact Skin and Downregulates the Allergen-Specific Response in Sensitized Mice

(2011) V. Dioszeghy et al.   JOURNAL OF IMMUNOLOGY

Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice

(2011) L Mascarell et al.   Mucosal Immunology

Tolerogenic T cells, Th1/Th17 cytokines and TLR2/TLR4 expressing dendritic cells predominate the microenvironment within distinct oral mucosal sites

(2010) J.-P. Allam et al.   ALLERGY

Local nasal immunotherapy

(2010) Luigi Andri et al.   ALLERGY

Epicutaneous immunotherapy on intact skin using a new delivery system in a murine model of allergy

(2010) L. Mondoulet et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Subcutaneous and sublingual immunotherapy and T regulatory cells: there is clinical relevance

(2010) G. Ciprandi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Sublingual Allergen-Specific Immunotherapy Adjuvanted with Monophosphoryl Lipid A: A Phase I/IIa Study

(2010) Oliver Pfaar et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Epicutaneous Immunotherapy Using a New Epicutaneous Delivery System in Mice Sensitized to Peanuts

(2010) Lucie Mondoulet et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Cow's milk epicutaneous immunotherapy in children: A pilot trial of safety, acceptability, and impact on allergic reactivity

(2010) Christophe Dupont et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nasal application of rBet v 1 or non–IgE-reactive T-cell epitope–containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses

(2010) Cornelia Egger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-β1 and IL-10–producing properties

(2010) Jean-Pierre Allam et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision

(2010) Jan L. Brożek et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Consolidated Standards of Reporting Trials (CONSORT) Statement applied to allergen-specific immunotherapy with inhalant allergens: A Global Allergy and Asthma European Network (GA2LEN) article

(2010) Philippe J. Bousquet et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen-specific immunotherapy for respiratory allergies: From meta-analysis to registration and beyond

(2010) Moisés A. Calderón et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunological Effects of Sublingual Immunotherapy: Clinical Efficacy Is Associated with Modulation of Programmed Cell Death Ligand 1, IL-10, and IgG4

(2010) S. Piconi et al.   JOURNAL OF IMMUNOLOGY

Lactic acid bacteria as adjuvants for sublingual allergy vaccines

(2010) Laurence Van Overtvelt et al.   VACCINE

Targeting the allergen to oral dendritic cells with mucoadhesive chitosan particles enhances tolerance induction

(2009) N. Saint-Lu et al.   ALLERGY

Mapping of the lingual immune system reveals the presence of both regulatory and effector CD4+T cells

(2009) L. Mascarell et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Efficacy and safety of 5-grass pollen sublingual immunotherapy tablets in patients with different clinical profiles of allergic rhinoconjunctivitis

(2009) H-J. Malling et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Implementation of pre-seasonal sublingual immunotherapy with a five-grass pollen tablet during optimal dosage assessment

(2009) F. Horak et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial

(2009) G. Senti et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Sublingual immunotherapy in children: complete and updated review supporting evidence of effect

(2009) Désirée Larenas-Linnemann   Current Opinion in Allergy and Clinical Immunology

Dendritic cells as potential targets for mucosal immunotherapy

(2009) Jean-Pierre Allam et al.   Current Opinion in Allergy and Clinical Immunology

Intralymphatic immunotherapy

(2009) Gabriela Senti et al.   Current Opinion in Allergy and Clinical Immunology

Local Nasal Immunotherapy: Efficacy of Dermatophagoides farinae-Chitosan Vaccine in Murine Asthma

(2009) Zhigang Liu et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Epicutaneous allergen administration: A novel approach for allergen-specific immunotherapy?

(2009) Thomas Werfel   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epicutaneous allergen administration as a novel method of allergen-specific immunotherapy

(2009) Gabriela Senti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Effect of Local Nasal Immunotherapy in Allergic Rhinitis: Using Strips of the AllergenDermatophagoides pteronyssinus

(2009) Jaw-Ji Tsai et al.   JOURNAL OF ASTHMA

Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy?

(2008) J.-P. Allam et al.   ALLERGY

Agreement of efficacy assessments for five-grass pollen sublingual tablet immunotherapy

(2008) A. Didier et al.   ALLERGY

Airway inflammation induced after allergic poly-sensitization can be prevented by mucosal but not by systemic administration of poly-peptides

(2008) K. Hufnagl et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy

(2008) Justin M. Skripak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oral tolerance, food allergy, and immunotherapy: Implications for future treatment

(2008) A. Wesley Burks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Specific oral tolerance induction in children with very severe cow's milk–induced reactions

(2008) Giorgio Longo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4+ T cells

(2008) Laurent Mascarell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years

(2008) Ronald Dahl et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity

(2008) James N. Francis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis

(2008) Ulrich Wahn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

(2008) Flurina Meiler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oral desensitization in children with immunoglobulin E-mediated cows milk allergy follow-up at 4yr and 8months

(2008) Paolo Meglio et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial

(2008) G. Senti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells

(2007) Jean-Pierre Allam et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY