Directing dendritic cell immunotherapy towards successful cancer treatment

Vaccination of a Melanoma Patient with Mature Dendritic Cells Pulsed with MAGE-3 Peptides Triggers the Activity of Nonvaccine Anti-Tumor Cells

(2014) J. Carrasco et al.   JOURNAL OF IMMUNOLOGY

Immunization of Malignant Melanoma Patients with Full-Length NY-ESO-1 Protein Using TLR7 Agonist Imiquimod as Vaccine Adjuvant

(2014) S. Adams et al.   JOURNAL OF IMMUNOLOGY

The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

(2014) W. Chen et al.   JOURNAL OF IMMUNOLOGY

Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

(2009) Celestia S. Higano et al.   CANCER

Metastatic tumour cells favour the generation of a tolerogenic milieu in tumour draining lymph node in patients with early cervical cancer

(2009) Alessandra Battaglia et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inhibition of Transforming Growth Factor- -Mediated Immunosuppression in Tumor-Draining Lymph Nodes Augments Antitumor Responses by Various Immunologic Cell Types

(2009) T. Fujita et al.   CANCER RESEARCH

Cytokine gene-mediated immunotherapy: Current status and future perspectives

(2009) Masahisa Jinushi et al.   CANCER SCIENCE

Limited Amounts of Dendritic Cells Migrate into the T-Cell Area of Lymph Nodes but Have High Immune Activating Potential in Melanoma Patients

(2009) P. Verdijk et al.   CLINICAL CANCER RESEARCH

Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer

(2009) F. M. Speetjens et al.   CLINICAL CANCER RESEARCH

Sensing pathogens and danger signals by the inflammasome

(2009) Joao HF Pedra et al.   CURRENT OPINION IN IMMUNOLOGY

In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb

(2009) Oihana Murillo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Improving vaccines by targeting antigens to dendritic cells

(2009) Ken Shortman et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Harnessing human CD1d restricted T cells for tumor immunity: progress and challenges

(2009) Madhav et al.   Frontiers in Bioscience-Landmark

Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines

(2009) Eynav Klechevsky et al.   HUMAN IMMUNOLOGY

Immune regulation by 4-1BB and 4-1BBL: complexities and challenges

(2009) Chao Wang et al.   IMMUNOLOGICAL REVIEWS

Molecular mechanism and function of CD40/CD40L engagement in the immune system

(2009) Raul Elgueta et al.   IMMUNOLOGICAL REVIEWS

Prolonged Survival of Dendritic Cell–Vaccinated Melanoma Patients Correlates With Tumor-Specific Delayed Type IV Hypersensitivity Response and Reduction of Tumor Growth Factor β-Expressing T Cells

(2009) Mercedes N. López et al.   JOURNAL OF CLINICAL ONCOLOGY

Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant

(2009) M. Paula Longhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phase Ib Trial Assessing Autologous, Tumor-pulsed Dendritic Cells as a Vaccine Administered With or Without IL-2 in Patients With Metastatic Melanoma

(2009) Bruce G. Redman et al.   JOURNAL OF IMMUNOTHERAPY

Adenovirus MART-1–engineered Autologous Dendritic Cell Vaccine for Metastatic Melanoma

(2009) Lisa H. Butterfield et al.   JOURNAL OF IMMUNOTHERAPY

Human Papillomavirus Type 16 (HPV-16) Virus-Like Particle L1-Specific CD8+ Cytotoxic T Lymphocytes (CTLs) Are Equally Effective as E7-Specific CD8+ CTLs in Killing Autologous HPV-16-Positive Tumor Cells in Cervical Cancer Patients: Implications for L1 Dendritic Cell-Based Therapeutic Vaccines

(2009) S. Bellone et al.   JOURNAL OF VIROLOGY

Human Th17 cells in infection and autoimmunity

(2009) Federica Sallusto et al.   MICROBES AND INFECTION

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

(2009) Caroline L Sokol et al.   NATURE IMMUNOLOGY

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy

(2009) Rajesh T. Gandhi et al.   VACCINE

C-type lectins on dendritic cells: key modulators for the induction of immune responses

(2008) Yvette van Kooyk   BIOCHEMICAL SOCIETY TRANSACTIONS

Prostaglandin E2 enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells

(2008) P. Krause et al.   BLOOD

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

(2008) I. Caminschi et al.   BLOOD

Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer

(2008) Celestia S. Higano et al.   CANCER

Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration

(2008) A. C. Inge Boullart et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dendritic cells dysfunction in tumour environment

(2008) Karim Bennaceur et al.   CANCER LETTERS

Type 2 Bias of T Cells Expanded from the Blood of Melanoma Patients Switched to Type 1 by IL-12p70 mRNA-Transfected Dendritic Cells

(2008) K. Minkis et al.   CANCER RESEARCH

Safety and Immunogenicity Study of NY-ESO-1b Peptide and Montanide ISA-51 Vaccination of Patients with Epithelial Ovarian Cancer in High-Risk First Remission

(2008) C. S.M. Diefenbach et al.   CLINICAL CANCER RESEARCH

Phase I Safety and Pharmacokinetic Study of CT-011, a Humanized Antibody Interacting with PD-1, in Patients with Advanced Hematologic Malignancies

(2008) R. Berger et al.   CLINICAL CANCER RESEARCH

Promises and challenges for the development ofListeria monocytogenes-based immunotherapies

(2008) Dirk G Brockstedt et al.   Expert Review of Vaccines

Intercellular Adhesion Molecule-1-Dependent Stable Interactions between T Cells and Dendritic Cells Determine CD8+ T Cell Memory

(2008) Alix Scholer et al.   IMMUNITY

Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy

(2008) Karl S. Peggs et al.   IMMUNOLOGICAL REVIEWS

Enhancing the clinical activity of granulocyte-macrophage colony-stimulating factor-secreting tumor cell vaccines

(2008) Masahisa Jinushi et al.   IMMUNOLOGICAL REVIEWS

Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses

(2008) Sandra J van Vliet et al.   IMMUNOLOGY AND CELL BIOLOGY

Presentation of lipid antigens to T cells

(2008) Lucia Mori et al.   IMMUNOLOGY LETTERS

KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity

(2008) Mojca Skoberne et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunization With Analog Peptide in Combination With CpG and Montanide Expands Tumor Antigen-specific CD8+ T Cells in Melanoma Patients

(2008) Julien Fourcade et al.   JOURNAL OF IMMUNOTHERAPY

Suppressive Influences in the Immune Response to Cancer

(2008) Vincenzo Bronte et al.   JOURNAL OF IMMUNOTHERAPY

Type 1-polarized dendritic cells loaded with autologous tumor are a potent immunogen against chronic lymphocytic leukemia

(2008) Je-Jung Lee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Engineered lentivector targeting of dendritic cells for in vivo immunization

(2008) Lili Yang et al.   NATURE BIOTECHNOLOGY

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

(2008) J. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SOCS regulation of the JAK/STAT signalling pathway

(2008) Ben A. Croker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

New horizons in adjuvants for vaccine development

(2008) Steven G. Reed et al.   TRENDS IN IMMUNOLOGY

Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers

(2008) Pierre Vandepapelière et al.   VACCINE