Alternatives to calcineurin inhibition in renal transplantation: belatacept, the first co-stimulation blocker

A Randomized, Multicenter Study of Steroid Avoidance, Early Steroid Withdrawal or Standard Steroid Therapy in Kidney Transplant Recipients

(2010) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Sotrastaurin, a Novel Small Molecule Inhibiting Protein Kinase C: First Clinical Results in Renal-Transplant Recipients

(2010) K. Budde et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Phase III Study of Belatacept Versus Cyclosporine in Kidney Transplants from Extended Criteria Donors (BENEFIT-EXT Study)

(2010) A. Durrbach et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)

(2010) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Inducing CTLA-4-Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation

(2010) N. Poirier et al.   Science Translational Medicine

Memory T-cell-specific therapeutics in organ transplantation

(2009) Andrew J Page et al.   Current Opinion in Organ Transplantation

Abatacept Does Not Induce Direct Gene Expression Changes in Antigen-Presenting Cells

(2009) Julie A. Carman et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Dendritic Cells Secrete the Immunosuppressive HLA-G Molecule upon CTLA4-Ig Treatment: Implication in Human Renal Transplant Acceptance

(2009) R. Bahri et al.   JOURNAL OF IMMUNOLOGY

Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates

(2009) Tim A Weaver et al.   NATURE MEDICINE

Assessment of Belatacept-Mediated Costimulation Blockade Through Evaluation of CD80/86-Receptor Saturation

(2009) Robert Latek et al.   TRANSPLANTATION

Monitoring of the Immunomodulatory Effect of CP-690,550 by Analysis of the JAK/STAT Pathway in Kidney Transplant Patients

(2009) Monique E. Quaedackers et al.   TRANSPLANTATION

What's Next in the Pipeline

(2008) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation

(2008) J. A. Bluestone et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chronic allograft dysfunction: can we use mammalian target of rapamycin inhibitors to replace calcineurin inhibitors to preserve graft function?

(2008) Ravinder K Wali et al.   Current Opinion in Organ Transplantation

Interaction of human PD-L1 and B7-1

(2008) Manish J. Butte et al.   MOLECULAR IMMUNOLOGY

HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression

(2008) Tatsuo Kawai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tolerance and Chimerism after Renal and Hematopoietic-Cell Transplantation

(2008) John D. Scandling et al.   NEW ENGLAND JOURNAL OF MEDICINE

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction

(2007) Patricia M. Davis et al.   CLINICAL IMMUNOLOGY

CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization

(2007) Helga Schneider et al.   EUROPEAN JOURNAL OF IMMUNOLOGY