Clinical development of combination strategies in immunotherapy: are we ready for more than one investigational product in an early clinical trial?

Palettes of Vaccines and Immunostimulatory Monoclonal Antibodies for Combination

(2009) I. Melero et al.   CLINICAL CANCER RESEARCH

Anti-Programmed Death-1 Synergizes with Granulocyte Macrophage Colony-Stimulating Factor-Secreting Tumor Cell Immunotherapy Providing Therapeutic Benefit to Mice with Established Tumors

(2009) B. Li et al.   CLINICAL CANCER RESEARCH

OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis

(2009) Daniel Hirschhorn-Cymerman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy

(2009) Y. H. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer

(2009) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy

(2008) R. Houot et al.   BLOOD

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

(2008) M. A. Morse et al.   BLOOD

Combination Therapy with Cisplatin and Anti-4-1BB: Synergistic Anticancer Effects and Amelioration of Cisplatin-Induced Nephrotoxicity

(2008) Y. H. Kim et al.   CANCER RESEARCH

Translational Research Working Group Developmental Pathway for Immune Response Modifiers

(2008) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Immunogenic cancer cell death: a key-lock paradigm

(2008) Antoine Tesniere et al.   CURRENT OPINION IN IMMUNOLOGY

Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies

(2008) Juliet C. Gray et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation

(2008) Jasmin T. Ney et al.   HEPATOLOGY

Cancer Immunotherapy by Dendritic Cells

(2008) Cornelis J.M. Melief   IMMUNITY

Twelve immunotherapy drugs that could cure cancers

(2008) Martin A. ‘Mac’ Cheever   IMMUNOLOGICAL REVIEWS

The anticancer immune response: indispensable for therapeutic success?

(2008) Laurence Zitvogel et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

(2008) David Sancho et al.   JOURNAL OF CLINICAL INVESTIGATION

The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells

(2008) Godwin Nchinda et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness

(2008) Gerald Willimsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural killer cell–directed therapies: moving from unexpected results to successful strategies

(2008) Magali Terme et al.   NATURE IMMUNOLOGY

Cancer Immunology

(2008) Olivera J. Finn   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of Vulvar Intraepithelial Neoplasia with Topical Imiquimod

(2008) Manon van Seters et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas

(2008) A. Kruschinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA