Article
Biochemistry & Molecular Biology
Wendy A. Goodman, Shrikanth C. Basavarajappa, Angela R. Liu, Franklin D. Staback Rodriguez, Tailor Mathes, Parameswaran Ramakrishnan
Summary: Studies have shown that Sam68 is an important inflammatory driver in experimental colitis, reducing the expression of proinflammatory genes and suggesting that targeting Sam68 may hold promise for treating UC patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Fisheries
Zhendong Qin, V. Sarath Babu, Yanan Li, Fei Shi, Fanbin Zhan, Chun Liu, Jun Li, Li Lin
Summary: This study reveals that hemorrhagic venereal infection or tissue injury can result in the release of hemoglobin, which induces oxidative stress and inflammation in head-kidney macrophages. The oxidative activity of hemoglobin upregulates proinflammatory cytokine expression and induces apoptosis in macrophages.
Article
Pharmacology & Pharmacy
Yuan Kang, Zhuangzhuang Liu, Wenjing Li, Ximeng Li, Xiaoyu Zhang, Zhenlu Xu, Yuan Gao, Yun Qi
Summary: In this study, the anti-inflammatory and anti-oxidative activities of wintersweet flower were explored. The results showed that wintersweet flower can reduce the production of inflammatory substances and inhibit the NF-kappa B signaling pathway. In addition, wintersweet flower also exhibited antioxidant activity and reduced intracellular reactive oxygen species level.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wanqing Li, Hongxiang Zeng, Min Xu, Chenglong Huang, Linfen Tao, Jun Li, Ting Zhang, Hong Chen, Jing Xia, Chunli Li, Xi Li
Summary: Oleanolic acid improves insulin resistance and reduces adipose tissue inflammation in obese mice by modulating macrophage activation and mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Wei Li, Xiangping Zhou, Jialun Cai, Feijun Zhao, Ting Cao, Lichang Ning, Chunyi Luo, Xinhua Xiao, Shuangquan Liu
Summary: Tp0768 stimulation of macrophages increases IL-1 beta, IL-6, and IL-8 expression levels in a dose- and time-dependent manner. This process is mediated through ER stress and the ROS/NF-kappa B pathway, leading to the secretion of proinflammatory cytokines.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Wenbin Nan, Fan Wang, Hao Wang, Wenchi Xiao, Linxiao Li, Chao Zhang, Yulu Zhang, Linna Dai, Zhihao Xu, Guoyun Wan, Yongxue Wang, Hongli Chen, Qiqing Zhang, Yongwei Hao
Summary: Treating diabetic refractory wounds involves transitioning from an overactive inflammatory state to an anti-inflammatory state. A hydrogel containing tumor extracellular vesicles and a nitric oxide donor was designed to release active substances in response to the high levels of reactive oxygen species in the wound site, promoting wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Environmental Sciences
Kai Liu, Ying Li, Mujahid Iqbal, Zhaoxin Tang, Hui Zhang
Summary: Thiram is widely used in agriculture and its improper handling or storage may lead to environmental contamination. This review summarizes the impacts of thiram on different organs in animals, including oxidative stress, mitochondrial damage, and apoptosis. The study also explores the effects of thiram on skeletal development, angiogenesis, fibroblasts, erythrocytes, fertility, neurodegeneration, and immune damage. Understanding the molecular mechanisms of thiram toxicity in animals will aid in the development of treatment methods for thiram poisoning.
Article
Microbiology
Yanyan Li, Shaojie Yin, Xiaolan Chen, Feifei Shi, Jing Wang, Haifeng Yang
Summary: This study reveals that Paeoniflorin can alleviate inflammatory responses by inhibiting the activation of multiple signaling pathways and the production of cytokines. Additionally, it has been shown to scavenge intracellular reactive oxygen species, contributing to its anti-inflammatory effects.
Review
Immunology
Lang Pan, Spiros Vlahopoulos, Lloyd Tanner, Jesper Bergwik, Attila Bacsi, Zsolt Radak, Arne Egesten, Xueqing Ba, Allan R. Brasier, Istvan Boldogh
Summary: Recent research has revealed the non-random distribution of 8-oxoguanine induced by reactive oxygen species, suggesting its epigenetic effects. 8-oxoguanine DNA glycosylase 1 (OGG1), the repair protein for 8-oxoGua, has been found to participate in transcriptional initiation and transmit acute inflammatory signals in airway epithelial cells. The interactions between epithelial-mesenchymal and epithelial-immune contribute to the development of chronic pulmonary diseases through inflammatory remodeling.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Qingxi Yue, Wen Zhang, Shumeng Lin, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Liduo Yue, Baigenzhin Abay, Ming Li, Lihong Fan
Summary: This study found that Ejiao has a protective effect and can reduce inflammation and oxidative stress, decrease cell pyroptosis, and improve lung injury. This finding may have important implications for the prevention and treatment of acute lung injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Guilhem Lalle, Julie Twardowski, Yenkel Grinberg-Bleyer
Summary: NF-kappa B plays a crucial role in immune responses to cancer and could be targeted by novel immunotherapies.
Article
Oncology
Olivia K. Provance, Eric S. Geanes, Asona J. Lui, Anuradha Roy, Sean M. Holloran, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Joan Lewis-Wambi
Summary: Overexpression of IFITM1 in TNBC promotes tumor progression, but targeting IFITM1 can inhibit cell proliferation and invasion through the NF-kappa B signaling pathway. Parthenolide, identified as an NF kappa B inhibitor, shows potential as a cytotoxic agent for TNBC treatment.
Article
Biochemistry & Molecular Biology
Shuyun Liu, Ling Li, Peng Lou, Meng Zhao, Yizhuo Wang, Minghai Tang, Meng Gong, Guangneng Liao, Yujia Yuan, Lan Li, Jie Zhang, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu
Summary: Impaired BCAA catabolism is strongly associated with chronic inflammation and tissue damage in T2DM, and this effect is at least partly due to the BCKAs-induced macrophage oxidative stress. Targeting BCAA catabolism is a potential strategy to attenuate T2DM and its complications.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Angela Rose Liu, Parameswaran Ramakrishnan
Summary: NF-kappa B is a crucial transcription factor family that plays a central role in regulating immune responses, inflammation, cell survival, and apoptosis. O-GlcNAcylation controls NF-kappa B activity, affecting cancer cell proliferation, survival, and metastasis, acting as a link between inflammation and cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Virology
Raymond Tshepiso Makola, Joe Kgaladi, Garland Kgosi More, Petrus Jansen van Vuren, Janusz Tadeusz Paweska, Thabe Moses Matsebatlela
Summary: This study demonstrates that lithium inhibits NF-kB nuclear translocation and modulates inflammation profiles in RVFV-infected Raw 264.7 macrophage cells.
Article
Dermatology
Katarzyna Osipowicz, Agnieszka Kalinska-Bienias, Cezary Kowalewski, Katarzyna Wozniak
INTERNATIONAL WOUND JOURNAL
(2017)
Letter
Dermatology
Bartlomiej Kwiek, Anna Lesniewska, Cezary Kowalewski, Katarzyna Wozniak
JOURNAL OF DERMATOLOGICAL SCIENCE
(2017)
Article
Dermatology
Nina van Beek, Cornelia Daehnrich, Nora Johannsen, Susanne Lemcke, Stephanie Goletz, Franziska Huebner, Giovanni Di Zenzo, Marian Dmochowski, Kossara Drenovska, Shamir Geller, Michael Horn, Cezary Kowalewski, Ljiljana Medenica, Dedee F. Murrell, Aikaterini Patsatsi, Soner Uzun, Snejina Vassileva, Detlef Zillikens, Wolfgang Schlumberger, Enno Schmidt
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2017)
Article
Dermatology
Bartlomiej Kwiek, Marcin Ambroziak, Katarzyna Osipowicz, Cezary Kowalewski, Michal Rozalski
DERMATOLOGIC SURGERY
(2018)
Article
Biochemistry & Molecular Biology
Jolanta Czerwiriska, Malgorzata Nowak, Patrycja Wojtczak, Dorota Dziuban-Lech, Jaroslaw M. Ciesla, Daria Kolata, Beata Gajewska, Anna Baranczyk-Kuzma, Andria R. Robinson, Hillary L. Shane, Siobhan Q. Gregg, Lora H. Rigatti, Matthew J. Yousefzadeh, Aditi U. Gurkar, Sara J. McGowan, Konrad Kosicki, Malgorzata Bednarek, Ewelina Zarakowska, Daniel Gackowski, Ryszard Olinski, Elzbieta Speina, Laura J. Niedernhofer, Barbara Tudek
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Letter
Allergy
Dominik Ludew, Katarzyna Wertheim-Tysarowska, Katarzyna Budnik, Alicja Grabarczyk, Cezary Kowalewski, Monika Kapinska-Mrowiecka
POSTEPY DERMATOLOGII I ALERGOLOGII
(2018)
Letter
Allergy
Alicja Adaszewska, Norito Ishii, Jadwiga Dwilewicz-Trojaczek, Katarzyna Wozniak, Takashi Hashimoto, Cezary Kowalewski
POSTEPY DERMATOLOGII I ALERGOLOGII
(2018)
Letter
Allergy
Katarzyna Osipowicz, Cezary Kowalewski, Katarzyna Wozniak
POSTEPY DERMATOLOGII I ALERGOLOGII
(2018)
Review
Dermatology
Beata Jakubowska, Cezary Kowalewski, Norito Ishii, Takashi Hashimoto, Katarzyna Wozniak
INTERNATIONAL WOUND JOURNAL
(2018)
Article
Dermatology
Agnieszka Kalinska-Bienias, Emilia Kowalczyk, Pawel Jagielski, Cezary Kowalewski, Katarzyna Wozniak
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Emilia Grosicka-Maciag, Dagmara Kurpios-Piec, Katarzyna Wozniak, Cezary Kowalewski, Maria Szumilo, Nadzieja Drela, Ewelina Kiernozek, Piotr Suchocki, Iwonna Rahden-Staron
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2019)
Article
Genetics & Heredity
Agnieszka Kalinska-Bienias, Agnieszka Pollak, Cezary Kowalewski, Urszula Lechowicz, Piotr Stawinski, Aleksandra Gergont, Joanna Kosinska, Ewa Pronicka, Pawel Kowalski, Katarzyna Wozniak, Rafal Ploski
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2017)
Article
Dermatology
Agnieszka Kalinska-Bienias, Katarzyna Lukowska-Smorawska, Pawel Jagielski, Cezary Kowalewski, Katarzyna Wozniak
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2017)
Article
Medicine, Research & Experimental
Agnieszka Kalinska-Bienias, Beata Jakubowska, Cezary Kowalewski, Dedee F. Murrell, Katarzyna Wozniak
ADVANCES IN MEDICAL SCIENCES
(2017)