Article
Immunology
Shinichiro Saeki, Atsushi Fukui, Chuxian Mai, Ryu Takeyama, Ayano Yamaya, Hiroaki Shibahara
Summary: This study investigates the role of NK cells in endometriosis and finds that the expression of activating receptors and inhibitory receptors on NK cells is decreased in endometriosis patients, while the production of TNF-alpha and IFN-gamma is increased. These findings suggest that the cytotoxic function of NK cells is inhibited in endometriosis, leading to the accumulation of endometrial cells in the abdominal cavity and the production of excessive TNF-alpha and IFN-gamma.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Immunology
Lu Yang, Li Sun, Yalan Cao, Qi Wang, Anni Song, Ru Zhu, Wenqi Liu, Shengjun Lu
Summary: This study provides the first in vivo evidence that MULT1 is a favorable anti-fibrosis factor in the context of schistosomiasis-associated hepatic fibrosis. By modulating the proportion and function of immune cells, MULT1 can improve the immune microenvironment affected by schistosomiasis infection and inhibit liver fibrosis.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Tsukasa Nabekura, Akira Shibuya
Summary: Innate lymphoid cells (ILCs) play vital roles in host protection and immune modulation, with ILC1s producing cytokines against pathogens and promoting tissue protection and metabolism.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Abrar Ul Haq Khan, Melinda Blimkie, Doo Seok Yang, Mandy Serran, Tyler Pack, Jin Wu, Ji-Young Kang, Holly Laakso, Seung-Hwan Lee, Yevgeniya Le
Summary: LDR significantly influenced the proportion, proliferation, activation, and function of immune cells, particularly NK and T cells, but had no noticeable impact on mammary cancer development. The study also demonstrated the modulation of the cross-talk between NKG2D receptor and its ligands by LDR exposure at different time points.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Marina Saresella, Federica Piancone, Ivana Marventano, Ambra Hernis, Daria Trabattoni, Mattia Invernizzi, Francesca La Rosa, Mario Clerici
Summary: The study found that receiving the BNT162b2 vaccine significantly increased the number of inflammatory monocytes and various types of NK cells, as well as enhanced the production of interferon-gamma and the content of perforin and granzyme in NK cells. The vaccine also reduced the expression of the inhibitory receptor ILT-2 and increased the expression of the stimulatory molecule 2DS2. These effects were long-lasting and were further enhanced with each vaccine dose. It is worth noting that the reduction of ILT-2 expressing NK cells was more significant in individuals who had recovered from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Nadine Landolina, Francesca Romana Mariotti, Tiziano Ingegnere, Claudia Alicata, Biancamaria Ricci, Andrea Pelosi, Irene Veneziani, Bruno Giuseppe Azzarone, Cecilia Garlanda, Alberto Mantovani, Lorenzo Moretta, Enrico Maggi
Summary: This study aimed to investigate the role of IL-1R8 in human NK cells and optimize its silencing conditions. The results showed that silencing IL-1R8 can enhance the activity and anti-tumor response of NK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Farshad Babaeijandaghi, Adrianna Paiero, Reece Long, Lin Wei Tung, Shannon Percival Smith, Ryan Cheng, Joshua Smandych, Nasim Kajabadi, Chih-Kai Chang, Amirhossein Ghassemi, William D. M. Kennedy, Hesham Soliman, Peter W. Schutz, Fabio M. Rossi
Summary: In this study, it is found that natural killer (NK) cells are the main source of IFN gamma in regenerating muscle. The production of IFN gamma is also limited to a small population of T cells. However, NK cells do not play a major role in muscle regeneration. The absence of IFN gamma per se has no effect on muscle regeneration, but its role is partially unmasked when TNF alpha is also neutralized.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Baige Yao, Qinglan Yang, Yao Yang, Yana Li, Hongyan Peng, Shuting Wu, Lili Wang, Shuju Zhang, Minghui Huang, Erqiang Wang, Peiwen Xiong, Ting Luo, Liping Li, Sujie Jia, Yafei Deng, Youcai Deng
Summary: The study identified Daphnetin as a natural product capable of promoting human NK cell activation via the PI3K-Akt-mTOR signaling pathway in the presence of IL-12, also enhancing its direct cytotoxicity against tumor cells. The findings suggest a potential application for Daphnetin as a complementary immunomodulator in cancer treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Cheng Cao, Junfeng Jiang, Min Liu, Yaping Dai, Tianzhi Chang, Tuo Ji, Fang Gong
Summary: This study investigated the impact of COVID-19 inactivated vaccine on innate immune cells and found that the distribution of monocytes and NK cells was altered, and robust IFN-gamma-producing NK cell response was elicited by CoronaVac vaccination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Reem Alkhayer, Viviane Ponath, Miriam Frech, Till Adhikary, Johannes Graumann, Andreas Neubauer, Elke Pogge von Strandmann
Summary: This study identifies the transcription factor KLF4 as associated with the MICA promoter, and demonstrates that pharmacological activation of KLF4 leads to increased expression of MICA in AML cells. The small compound APTO253, which activates KLF4, also inhibits MYC expression and causes DNA damage in AML cells. The induction of MICA expression renders AML cells more susceptible to NK cell-mediated killing, suggesting a potential therapeutic approach for targeting AML cells.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Rui-Ting Liu, Wei Li, Dong Guo, Chun-Lin Yang, Jie Ding, Jian-Xin Xu, Rui-Sheng Duan
Summary: The study found that NK cells in patients with myasthenia gravis have abnormal immune-regulation on CD4(+) T cells and Tfh cells, which may contribute to the immune-pathological mechanism of MG.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Hanna Kim, Jae-Eun Byun, Suk Ran Yoon, Hashem Koohy, Haiyoung Jung, Inpyo Choi
Summary: The study found that SARS-CoV-2 S protein peptides can bind to the NKG2D receptor on NK cells, enhancing immune responses by increasing NK cytotoxicity towards lung cancer cells and stimulating IFN-gamma production. This novel interaction between SARS-CoV-2 and NK cells may have potential clinical applications as a therapeutic target for COVID-19.
CELLULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elisabetta Vulpis, Luisa Loconte, Chiara Cassone, Fabrizio Antonangeli, Giulio Caracciolo, Laura Masuelli, Francesca Fazio, Maria Teresa Petrucci, Cinzia Fionda, Alessandra Soriani, Cristina Cerboni, Marco Cippitelli, Angela Santoni, Alessandra Zingoni
Summary: Natural Killer (NK) cells are innate cytotoxic lymphoid cells that play a crucial role in cancer immunosurveillance. The secretion of NKG2D ligands (NKG2DLs) through extracellular vesicles (EVs) is a mechanism used by cancer cells to evade NKG2D-mediated immunosurveillance. This study investigates the spreading of NKG2DLs through EV-mediated cross-dressing on multiple myeloma (MM) cells and the potential therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Xiulan Ao, Qiaorong Gan, Xuan Huang, Dongpeng Bao, Xuwei Wu, Qiuxiang Lin, Aifang Lin, Yating Ding, Lingxia Wang, Yanping Chen, Zuxiong Huang
Summary: TLR8 expression was up-regulated in NK cells of patients with CHB, but accompanied by insufficient IFN-gamma production. The response of NK cells to TLR8 agonist stimulation was inhibitory in CHB patients. Targeting TLR8 partially rescued the IFN-gamma insufficiency in NK cells, and combining TLR8 agonist with NA therapy could enhance the antiviral effect of NK cells.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Immunology
Qinglan Yang, Shuju Zhang, Shuting Wu, Baige Yao, Lili Wang, Yana Li, Hongyan Peng, Minghui Huang, Qinghua Bi, Peiwen Xiong, Liping Li, Yafei Deng, Youcai Deng
Summary: This study identified nafamostat mesylate (NM) as a selective stimulator of IFN-gamma production by NK cells, providing a new strategy for the prevention and treatment of infection or cancer in select populations.
IMMUNOLOGIC RESEARCH
(2022)
Article
Oncology
A. Jafarzadeh, H. Fooladseresht, M. Nemati, Z. Assadollahi, A. Sheikhi, A. Ghaderi
Letter
Dermatology
Abdolkarim Sheikhi, Mohsen Azarbeig, Hamid Karimi
ANNALS OF DERMATOLOGY
(2014)
Article
Pharmacology & Pharmacy
Abdolkarim Sheikhi, Sara Razdar, Haleh Rahmanpour, Nouraddin Mousavinasab, Hossein Barzegar Ganji, Abdollah Jafarzadeh
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2015)
Article
Biochemistry & Molecular Biology
A. Jafarzadeh, M. Jamali, R. Mahdavi, H. A. Ebrahimi, H. Hajghani, A. Khosravimashizi, M. Nemati, H. Najafipour, A. Sheikhi, M. M. Mohammadi, H. Daneshvar
JOURNAL OF MOLECULAR NEUROSCIENCE
(2015)
Article
Andrology
A. Sheikhi, M. Jalali, M. Gholamian, A. Jafarzadeh, S. Jannati, N. Mousavifar
Article
Oncology
Elisa C. Toffoli, Abdolkarim Sheikhi, Roeland Lameris, Lisa A. King, Amanda van Vliet, Bruce Walcheck, Henk M. W. Verheul, Jan Spanholtz, Jurriaan Tuynman, Tanja D. de Gruijl, Hans J. van der Vliet
Summary: A novel bispecific single domain antibody (VHH) targeting CD16 on NK cells and EGFR on tumor cells enhanced NK cell activation and cytotoxicity, showing potential for cancer therapy. This approach demonstrated efficacy in controlling tumor growth in colorectal cancer cell co-cultures, suggesting promise for further exploration in NK cell-based therapeutic approaches.
Review
Virology
Leili Baghaie, Fleur Leroy, Mehdi Sheikhi, Abdollah Jafarzadeh, Myron R. Szewczuk, Abdolkarim Sheikhi
Summary: Mutations and glycosylation can decrease the sensitivity of immunogenic epitopes to neutralizing antibodies. Despite this, previous antibodies or T cell receptors can still bind and neutralize the virus, even with reduced affinity. The paper argues for universal vaccination to prevent further mutations and suggests the development of vaccines and drugs targeting new epitopes.
Article
Public, Environmental & Occupational Health
Shadi Akbarian, Mehdi Sheikhi, Parichehr Khedri, Narges Baharifar, Fatemeh Khalaf Shamsabadi, Mohammad Reza Davidi, Hossein Ali Khazaei, Hamidali Assarian, Abdolkarim Sheikhi
Summary: The study aims to investigate the association between clinical manifestations and humoral immune responses in COVID-19 patients. The findings reveal that serum IgG levels are significantly elevated in moderate and severe cases compared to mild cases. The production of IgG is also significantly heightened in severe cases. IgM and IgG levels peak initially and decrease over time.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Chemistry, Medicinal
Forough Saki, Abdolkarim Sheikhi, Gholam Hosein Ranjbar Omrani, Hamid Karimi, Mohammad Hossein Dabbaghmanesh, Seyed Nouraddin Mousavinasab
Review
Immunology
Abdolkarim Sheikhi, Abdollah Jafarzadeh, Parviz Kokhaei, Mohammad Hojjat-Farsangi
IRANIAN JOURNAL OF IMMUNOLOGY
(2016)
Article
Chemistry, Medicinal
A. Sheikhi, M. Shakerian, H. Giti, M. Baghaeifar, A. Jafarzadeh, V. Ghaed, M. R. Heibor, N. Baharifar, Z. Dadafarin, G. Bashirpour
Article
Medicine, Research & Experimental
Abdollah Jafarzadeh, Kayhan Minaee, Ali-Reza Farsinejad, Maryam Nemati, Arezu Khosravimashizi, Hamid Daneshvar, Mohammad Mehdi Mohammadi, Abdolkarim Sheikhi, Abbas Ghaderi
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2015)
Article
Endocrinology & Metabolism
Faranak Sharifi, Abdolkarim Sheikhi, Mahnaz Behdad, Nouraddin Mousavinasab
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2010)