Review
Immunology
Jonathan Bordat, Sebastien Maury, Mathieu Leclerc
Summary: Allo-HSCT recipients are highly vulnerable to COVID-19 due to immunodeficiency, and changes in clinical practice have been implemented to reduce the risk. mRNA vaccines have shown effectiveness in preventing severe forms of the disease, but Allo-HSCT recipients may have a poor response to vaccination. Challenges include adapting vaccine protection to emerging variants.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Pierre Gaudeaux, Ranjita Devi Moirangthem, Aurelie Bauquet, Laura Simons, Akshay Joshi, Marina Cavazzana, Olivier Negre, Shabi Soheili, Isabelle Andre
Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) is a preferred treatment for various blood diseases. However, this approach is hindered by graft-versus-host disease (GvHD), infections, and relapses due to persistent T-cell immunodeficiency. One major challenge is to accelerate T-cell recovery and shorten the period of immune deficiency. Adoptive transfer of cell populations that can generate mature T cells faster than hematopoietic stem cells (HSCs) is of great interest. This review summarizes current advances in the characterization of thymus seeding progenitors and discusses the opportunities for T-cell progenitor-based therapy manufacturing.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jintao Xia, Xuejie Li, Genyong Gui, Jian Wu, Shengnan Gong, Yuxin Shang, Jun Fan
Summary: This study evaluated the early immune response of recipients with disparate HCMV outcomes and found that HCMV-specific IFN-gamma secreting cells, HCMV IgG, and absolute lymphocyte count could represent the humoral and cellular immune response. Early monitoring of these immune markers could enable prediction of HCMV outcomes posttransplant and assessment of the severity of HCMV DNAemia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Richard J. Lin, Harold K. Elias, Marcel R. M. van den Brink
Summary: Older patients with hematologic malignancies are increasingly undergoing allogeneic hematopoietic cell transplantation, with aging-related thymic dysfunction and other aging hallmarks potentially impacting immune reconstitution post-transplantation. Mechanism-based therapeutic interventions are being discussed to address these issues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Jiayu Wang, Meng Yuan, Guanghua Zhu, Runhui Wu, Chenguang Jia, Bin Wang, Jie Zheng, Jie Ma, Maoquan Qin, Sidan Li
Summary: This study analyzed the immune reconstitution of pediatric patients with aplastic anemia after hematopoietic stem-cell transplantation (HSCT) and found that early rapid immune reconstitution is a good predictor of clinical prognosis in children with AA.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Mathieu Leclerc, Rabah Redjoul, Anne Le Bouter, Florence Beckerich, Christine Robin, Vincent Parinet, Cecile Pautas, Dehbia Menouche, Selwa Bouledroua, Lydia Roy, Ludovic Cabanne, Yakout Nait-Sidenas, Slim Fourati, Sebastien Maury
Summary: Hematopoietic stem cell transplant recipients show lower immune response to BNT162b2 mRNA vaccine after 6 months, with peak antibody levels predicting persistent protection. Immunosuppressive drugs and low lymphocyte counts correlate with lower antibody levels.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Cell & Tissue Engineering
Zheng-Li Xu, Xiao-Jun Huang
Summary: Allogeneic hematopoietic stem cell transplantation is widely used in treating hematological diseases, with optimized grafts being crucial for improving outcomes. However, there is currently no uniform standard for optimized grafts in transplantation. Future research may focus on identifying the cellular elements responsible for the effects of allo-HSCT.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Anna Soderstrom, Sofie Vonlanthen, Kerstin Jonsson-Videsater, Stephan Mielke, Hannes Lindahl, Johan Torlen, Michael Uhlin
Summary: This study found that measuring TREC levels can predict the prognosis of adult AML patients after bone marrow transplantation, especially overall survival. Lower TREC levels were associated with viral infections and CMV reactivation. KREC levels were not associated with clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Riccardo Masetti, Daniele Zama, Davide Leardini, Edoardo Muratore, Silvia Turroni, Patrizia Brigidi, Andrea Pession
Summary: The gut microbiome plays a significant role in hematopoietic stem cell transplantation, with its metabolites mediating interactions between intestinal microbial communities and the host. New data offer a fresh perspective on the role of microbiome-derived metabolites in transplant settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Sikemi Ibikunle, Dolores Grosso, Usama Gergis
Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative option for multiple hematological conditions. The two-step approach to HSCT, described here, aims to achieve an optimal balance in immune recovery, graft-versus-host disease control, and disease control. This review highlights key results from studies over the past two decades and discusses current strategies to optimize graft-versus-tumor effect and limit transplant-related toxicities.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Longmei Shang, Maxwell Duah, Yan Xu, Yiwen Liang, Dong Wang, Fan Xia, Lingling Li, Zengtian Sun, Zhiling Yan, Kailin Xu, Bin Pan
Summary: This study found a positive correlation between plasma IL-22 levels and blood TRECs levels at days 14 and 28 posttransplant in humans. Higher plasma IL-22 levels, occurrence of aGVHD, and age were significantly associated with higher blood TRECs levels at day 28 after allotransplant. An increase in plasma IL-22 levels during days 14 and 28 was linked to faster recovery of blood TRECs and naive T-cell levels in recipients. High TRECs levels at day 28 were associated with lower incidence of aGVHD, regardless of IL-22 levels. Other factors like age and infection also impacted plasma IL-22 levels in allotransplant recipients.
Article
Gastroenterology & Hepatology
Yosuke Okada, Hideki Nakasone, Yuhei Nakamura, Masakatsu Kawamura, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Yukiko Misaki, Kazuki Yoshimura, Shimpei Matsumi, Ayumi Gomyo, Aki Tanihara, Masaharu Tamaki, Machiko Kusuda, Kazuaki Kameda, Shun-Ichi Kimura, Shinichi Kako, Noriko Oyama-Manabe, Yoshinobu Kanda
Summary: Pancreatic atrophy is associated with chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation. The recovery of pancreatic thickness plays a crucial role in body weight recovery, but pancreatic atrophy may have a negative impact on prognosis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Leyre Bento, Mariana Canaro, Jose Maria Bastida, Antonia Sampol
Summary: Thrombopoietin receptor agonists have shown good tolerability and efficacy as a new strategy for treating post-transplant thrombocytopenia. Prospective trials are needed to confirm these results.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Infectious Diseases
Fatima Allaw, Sara F. Haddad, Johnny Zakhour, Souha S. Kanj
Summary: Cytomegalovirus (CMV) is a common infection in immunocompromised patients, especially those undergoing allo-HSCT. Recent management strategies include pre-emptive treatment with frequent CMV PCR monitoring and the use of new drugs like letermovir. Treatment of CMV disease is challenging due to drug resistance, but promising results have been seen with maribavir and other alternative treatments such as immunotherapy, artesunate, and leflunomide.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Clinical Neurology
Zhuo Wang, Munan Zhao, Sujun Gao
Summary: The incidence of epileptic seizures after allogeneic hematopoietic stem cell transplantation has raised concerns among clinicians for its impact on patient survival and quality of life. This review aims to elucidate the incidence, etiologies, mechanisms, clinical manifestations, therapeutic schedule, and prognosis of post-transplantation seizures to improve doctors' understanding and management of this complication for better patient outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arnab Ghosh, Melody Smith, Scott E. James, Marco L. Davila, Enrico Velardi, Kimon V. Argyropoulos, Gertrude Gunset, Fabiana Perna, Fabiana M. Kreines, Emily R. Levy, Sophie Lieberman, Hillary V. Jay, Andrea Z. Tuckett, Johannes L. Zakrzewski, Lisa Tan, Lauren F. Young, Kate Takvorian, Jarrod A. Dudakov, Robert R. Jenq, Alan M. Hanash, Ana Carolina F. Motta, George F. Murphy, Chen Liu, Andrea Schietinger, Michel Sadelain, Marcel R. M. van den Brink
Meeting Abstract
Hematology
Jennifer J. Tsai, Enrico Velardi, Yusuke Shono, Kimon Argyropoulos, Odette M. Smith, Amina Lazrak, Chen Liu, George F. Murphy, Ya-Yuan Fu, Alan M. Hanash, Robert R. Jenq, Jarrod A. Dudakov, Marcel R. M. van den Brink
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Meeting Abstract
Hematology
Anna Staffas, Marina Burgos da Silva, Ann E. Slingerland, Amino Lazrak, Melissa Docampo, Yusuke Shono, Benjamin Durham, Justin R. Cross, Amanda Pickard, Christoph Stein-Thoeringer, Enrico Velardi, Jennifer J. Tsai, Lorenz Jahn, Hillary Jay, Sophie Lieberman, Odette M. Smith, Eric G. Pamer, Jonathan U. Peled, Robert R. Jenq, Marcel R. M. van den Brink
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Microbiology
Anna Staffas, Marina Burgos da Silva, Ann E. Slingerland, Amina Lazrak, Curtis J. Bare, Corey D. Holman, Melissa D. Docampo, Yusuke Shono, Benjamin Durham, Amanda J. Pickard, Justin R. Cross, Christoph Stein-Thoeringer, Enrico Velardi, Jennifer J. Tsai, Lorenz Jahn, Hillary Jay, Sophie Lieberman, Odette M. Smith, Eric G. Pamer, Jonathan U. Peled, David E. Cohen, Robert R. Jenq, Marcel R. M. van den Brink
CELL HOST & MICROBE
(2018)
Correction
Biochemistry & Molecular Biology
Enrico Velardi, Jennifer J. Tsai, Stefan Radtke, Kirsten Cooper, Kimon V. Argyropoulos, Shieh Jae-Hung, Lauren F. Young, Amina Lazrak, Odette M. Smith, Sophie Lieberman, Fabiana Kreines, Yusuke Shono, Tobias Wertheimer, Robert R. Jenq, Alan M. Hanash, Prema Narayan, Zhenmin Lei, Malcolm A. Moore, Hans-Peter Kiem, Marcel R. M. van den Brink, Jarrod A. Dudakov
Article
Biochemistry & Molecular Biology
Enrico Velardi, Jennifer J. Tsai, Stefan Radtke, Kirsten Cooper, Kimon V. Argyropoulos, Shieh Jae-Hung, Lauren F. Young, Amina Lazrak, Odette M. Smith, Sophie Lieberman, Fabiana Kreines, Yusuke Shono, Tobias Wertheimer, Robert R. Jenq, Alan M. Hanash, Prema Narayan, Zhenmin Lei, Malcolm A. Moore, Hans-Peter Kiem, Marcel R. M. van den Brink, Jarrod A. Dudakov
Article
Hematology
Jennifer J. Tsai, Enrico Velardi, Yusuke Shono, Kimon V. Argyropoulos, Amanda M. Holland, Odette M. Smith, Nury L. Yim, Uttam K. Rao, Fabiana M. Kreines, Sophie R. Lieberman, Lauren F. Young, Amina Lazrak, Salma Youssef, Ya-Yuan Fu, Chen Liu, Cecilia Lezcano, George F. Murphy, Il-Kang Na, Robert R. Jenq, Alan M. Hanash, Jarrod A. Dudakov, Marcel R. M. van den Brink
Review
Immunology
Enrico Velardi, Emmanuel Clave, Lucas C. M. Arruda, Francesca Benini, Franco Locatelli, Antoine Toubert
Summary: The thymus plays a crucial role in T-cell development, but its function can be affected by various factors, including chemotherapy, conditioning regimen, graft-versus-host disease, and steroid therapy. Despite its remarkable capacity to recover after damage, the pathways governing its regeneration are poorly understood. Tools for measuring thymic output can help assess thymic function.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Review
Immunology
David Granadier, Lorenzo Iovino, Sinead Kinsella, Jarrod A. Dudakov
Summary: The diversity of the T cell receptor repertoire in the thymus is crucial for immune responses against pathogens and malignancies, but thymic function is sensitive to negative stimuli such as acute insult or chronic damage. These insults can lead to decreased immune responses, highlighting the importance of maintaining thymic function for overall immune health.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Cell Biology
Sinead Kinsella, Cindy A. Evandy, Kirsten Cooper, Lorenzo Iovino, Paul C. DeRoos, Kayla S. Hopwo, David W. Granadier, Colton W. Smith, Shahin Rafii, Jarrod A. Dudakov
Summary: The study identifies a complex signal pathway triggered by apoptotic thymocytes during tissue damage, leading to increased production of IL-23 and BMP4 and ultimately promoting thymic regeneration. Pharmacological inhibition targeting this pathway enhances thymic function and offers a new strategy for restoring immune competence in patients with compromised thymic function.
Article
Surgery
Mattia Algeri, Enrico Velardi, Marco Spada, Federica Galaverna, Roberto Carta, Luciana Vinti, Giuseppe Palumbo, Stefania Gaspari, Andrea Pietrobattista, Emilia Boccieri, Marco Becilli, Paola Francalanci, Valentina Bertaina, Pietro Merli, Franco Locatelli
Summary: This report describes a case of operational tolerance in a patient who received combined liver transplantation and hematopoietic stem cell transplantation (HSCT) from different donors, without causing any sign of liver graft dysfunction.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Immunology
Enrico Velardi, Jennifer J. Tsai, Marcel R. M. van den Brink
Summary: This article discusses the importance of immune reconstitution, specifically of T cells, following periods of haematopoietic cell stress. Delayed or defective recovery of T cells can have significant clinical consequences, highlighting the need for therapeutic strategies to restore immune function.
NATURE REVIEWS IMMUNOLOGY
(2021)
Meeting Abstract
Hematology
Enrico Velardi, Jennifer J. Tsai, Stefan Radtke, Kirsten Cooper, Kimon Argyropoulos, Shieh Jae-Hung, Robert R. Jenq, Alan M. Hanash, Malcolm Moore, Hans-Peter Kiem, Jarrod A. Dudakov, Marcel R. M. van den Brink
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Meeting Abstract
Hematology
Kimon Argyropoulos, Enrico Velardi, Jennifer J. Tsai, Amina Lazrak, Lorenz Jahn, Jarrod A. Dudakov, Marcel R. M. van den Brink
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Immunology
Tobias Wertheimer, Enrico Velardi, Jennifer Tsai, Kirsten Cooper, Shiyun Xiao, Christopher C. Kloss, Katja J. Ottmueller, Zeinab Mokhtari, Christian Brede, Paul deRoos, Sinead Kinsella, Brisa Palikuqi, Michael Ginsberg, Lauren F. Young, Fabiana Kreines, Sophia R. Lieberman, Amina Lazrak, Peipei Guo, Florent Malard, Odette M. Smith, Yusuke Shono, Robert R. Jenq, Alan M. Hanash, Daniel J. Nolan, Jason M. Butler, Andreas Beilhack, Nancy R. Manley, Shahin Rafe, Jarrod A. Dudakov, Marcel R. M. van den Brink
SCIENCE IMMUNOLOGY
(2018)
