Review
Oncology
Alexandre Delpla, Thierry de Baere, Eloi Varin, Frederic Deschamps, Charles Roux, Lambros Tselikas
Summary: Thermal ablation plays an important role in managing lung metastases of colorectal cancer, providing good outcomes in terms of local tumor control and survival extension. Factors such as tumor size, proximity to bronchi or vessels, and ablation margin size can influence the efficacy of thermal ablation in treating these metastases.
Article
Medicine, General & Internal
Thomas J. Vogl, Lars Hammann, Hamzah Adwan
Summary: This study evaluated the tumor response and survival of patients with colorectal pulmonary metastases treated by TPCE alone or TPCE combined with MWA. The results showed that TPCE is an effective treatment for colorectal lung metastases, which can be performed alone or combined with MWA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Katerina Jerabkova-Roda, Amandine Dupas, Nael Osmani, Vincent Hyenne, Jacky G. Goetz
Summary: The intravascular behavior of tumor-derived extracellular vesicles (EVs) and circulating tumor cells (CTCs) plays a crucial role in the metastatic cascade. Understanding the role of cellular adhesion molecules (CAMs) and their endothelial ligands in dictating the arrest site and exit capacity of EVs/CTCs could provide insight into novel targets for therapies. Exploring the differences and similarities between CAMs on CTCs and EVs may help in understanding their role in organotropism of different cancer types.
Article
Biochemistry & Molecular Biology
Lin Yan, Sneha Sundaram, Bret M. Rust, Matthew J. Picklo, Michael R. Bukowski
Summary: Metabolomic analysis revealed significant differences in amino acid and energy metabolism in Lewis lung carcinoma (LLC) metastases compared to the lungs, and alterations in lipid metabolism during LLC metastatic progression. Understanding these metabolic differences can inform targeted studies for cancer prevention and treatment.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Kuei-Yen Tsai, Yu-Jia Chang, Chien-Yu Huang, G. M. Shazzad Hossain Prince, Hsin-An Chen, Precious Takondwa Makondi, Ying-Rou Shen, Po-Li Wei
Summary: This study found that heavily fucosylated glycans (HFGs) are overexpressed in colorectal cancer tissues compared to normal tissues. Treatment with anti-HFG monoclonal antibody showed cytotoxic effects in colorectal cancer cells and inhibited tumor growth in a xenograft mouse model. HFGs could be a potential therapeutic target for colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nikita Yabbarov, Elena Nikolskaya, Maria Sokol, Mariia Mollaeva, Margarita Chirkina, Irina Seregina, Mikhail Gulyaev, Yury Pirogov, Rem Petrov
Summary: This study demonstrates a dual-targeting drug delivery strategy that enhances the therapeutic efficacy by simultaneously targeting tumor endothelium and cell surface receptors. By functionalizing the nanodevice with selectin ligand and alpha-fetoprotein receptor-binding peptide, the strategy increases the accumulation and antitumor effect of the drug in tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yue Han, Xue Yan, Weihua Zhi, Ye Liu, Fei Xu, Dong Yan
Summary: This study retrospectively evaluated the safety and efficacy of percutaneous CT-guided microwave ablation in colorectal cancer lung metastases. The results showed that MWA therapy can be safely and effectively used for the treatment of selected CRC pulmonary metastases, and patients without liver metastases at the diagnosis of lung metastases have better prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Esther Strating, Sjoerd Elias, Guus van Scharrenburg, Kaisa Luoto, Andre Verheem, Inne Borel Rinkes, Herman Steen, Onno Kranenburg
Summary: Colorectal cancer peritoneal metastases are difficult to detect using conventional imaging methods. This study explores the potential use of a PDGFRB-binding llama nanobody in detecting peritoneal metastases in mice. The results demonstrate the potential value of PDGFRB-targeted molecular imaging as a novel strategy for the non-invasive detection of peritoneal metastases in colorectal cancer.
Review
Biochemistry & Molecular Biology
Agnieszka Rybarczyk-Kasiuchnicz, Rodryg Ramlau, Katarzyna Stencel
Summary: Lung cancer is a common malignant neoplasm that may progress to metastasize to the central nervous system, affecting the prognosis unfavorably. The discovery of EGFR-activating mutations and ALK rearrangements in lung adenocarcinoma patients has led to the introduction of small-molecule tyrosine kinase inhibitors for advanced-stage treatment. These inhibitors target different pathways to improve progression-free survival in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Pernilla Hansdotter, Peter Scherman, Maziar Nikberg, Sune H. H. Petersen, Erik Holmberg, Magnus Rizell, Peter Naredi, Ingvar Syk, COLOFOL study grp
Summary: The lungs are the second most common site for metachronous metastases in colorectal cancer, and the role of adjuvant chemotherapy is unclear. This study aimed to evaluate pulmonary recurrences in a modern multimodal treated population and their survival depending on management. The results showed that a high proportion of lung recurrences were possible to resect, with better survival rates observed in patients treated with surgery combined with chemotherapy.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sami U. Khan, Ying Xia, David Goodale, Gabriella Schoettle, Alison L. Allan
Summary: The research found that lung-derived selectins can promote the metastatic behavior of TNBC, while selectin knockout can reduce the metastatic progression of TNBC in the lungs. Further studies are aimed at elucidating the pro-metastatic mechanisms of lung-derived selectins and developing a lung-directed therapeutic approach.
Article
Surgery
Byung Min Lee, Jee Suk Chang, Woong Sub Koom, Hwa Kyung Byun, Han Sang Kim, Seung-Hoon Beom, Caleb Oh, Young Joo Suh, Joong Bae Ahn, Sang Joon Shin, Byung Jo Park, Seong Yong Park
Summary: This study aimed to assess the effect of local ablative therapy (LAT) on overall survival in patients with lung metastases from colorectal cancer (CRC). The results showed that patients treated with LAT had significantly higher survival rates compared to those treated with systemic therapy alone.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruben P. J. Meijer, Hidde I. Galema, Robin I. Faber, Okker Bijlstra, Alexander P. W. M. Maat, Francoise Cailler, Jerry Braun, Stijn Keereweer, Denise Hilling, Jacobus Burggraaf, Alexander Vahrmeijer, Merlijn Hutteman, SGM CLM Study Grp
Summary: This study assessed the feasibility of targeting colorectal lung metastases (CLM) with the carcinoembryonic antigen (CEA) specific fluorescent tracer SGM-101. The results showed that SGM-101 can achieve good targeting of tumor nodules and can be used for closed-field imaging, but improvements in imaging systems and patient selection are needed.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Medicine, General & Internal
Meritxell Molla, Julen Fernandez-Plana, Santiago Albiol, Constantino Fondevila, Ivan Vollmer, Carla Cases, Angeles Garcia-Criado, Jaume Capdevila, Carles Conill, Yliam Fundora, Carlos Fernandez-Martos, Estela Pineda
Summary: The prognosis for oligometastatic colorectal cancer has improved due to recent advances in new techniques and approaches such as new surgical procedures, better systemic treatments, percutaneous ablation, and stereotactic body radiation therapy. Factors to consider when deciding on the best approach include tumor factors, patient factors, and physician factors. These advances have presented challenges and opportunities for oncologic multidisciplinary teams to treat patients with limited liver and lung metastases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
M. J. van Amerongen, A. M. Vos, W. van der Woude, I. D. Nagtegaal, J. H. W. de Wilt, J. J. Futterer, J. J. Hermans
Summary: This study aimed to evaluate the relationship between CTP and histological biomarkers in CRLM patients. The results showed no significant correlation between CTP and pathological markers, but CTP may potentially non-invasively evaluate the prognostic marker of hypoxia in CRLM.