MPLA inhibits release of cytotoxic mediators from human neutrophils while preserving efficient bacterial killing

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

The function of neutrophils in sepsis

(2012) Melissa A. Kovach et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung

(2012) Arne Ittner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential expression of CD14-dependent and independent pathways for chemokine induction regulates neutrophil trafficking in infection

(2012) Shalaka Metkar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality

(2012) Issrah Jawad et al.   Journal of Global Health

In vivo evidence of oral vaccination with PLGA nanoparticles containing the immunostimulant monophosphoryl lipid A

(2011) Federica Sarti et al.   BIOMATERIALS

Monophosphoryl lipid A induced innate immune responses via TLR4 to enhance clearance of nontypeableHaemophilus influenzaeandMoraxella catarrhalisfrom the nasopharynx in mice

(2011) Takashi Hirano et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The Toll-Like Receptor 4 Agonist Monophosphoryl Lipid A Augments Innate Host Resistance to Systemic Bacterial Infection

(2011) Christopher D. Romero et al.   INFECTION AND IMMUNITY

CpG-ODN and MPLA Prevent Mortality in a Murine Model of Post-Hemorrhage-Staphyloccocus aureus Pneumonia

(2010) Antoine Roquilly et al.   PLoS One

C5a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients

(2009) Andrew Conway Morris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A

(2009) Caglar Cekic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

(2009) T. Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA