Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 89, Issue 3, Pages 352-358Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/icb.2010.136
Keywords
virus; T cells; HLA; immunotherapy; vaccine; human
Categories
Funding
- National Health and Medical Research Council, Australia
- National Health and Medical Research Council
Ask authors/readers for more resources
Human herpesviruses have coevolved with humans over millions of years, and adaptation of latent infection within the cells of the immune system is a unique characteristic of many of these viruses. Following primary infection, these herpesviruses establish an asymptomatic-persistent infection in healthy individuals that is strictly controlled by virus-specific CD8(+) and CD4(+) T cells. Here, we provide a brief overview of how the human immune system interacts with these latent viruses and regulates the lifelong host-virus relationship in healthy virus carriers. Extensive studies on T-cell-mediated immune regulation over the last decade has allowed researchers to successfully translate these findings into the clinical setting to treat various herpesvirus-associated diseases in transplant patients and individuals with virus-associated malignancies. It is highly likely that these newly emerging T-cell-based therapeutic and diagnostic technologies will revolutionize the clinical management of patients with herpesvirus-associated diseases. Immunology and Cell Biology (2011) 89, 352-358; doi:10.1038/icb.2010.136; published online 8 February 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available