Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 88, Issue 3, Pages 269-274Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/icb.2009.105
Keywords
gamma delta T cell; IgE; allergy; parasitic infection; lung; spleen and lymph nodes
Categories
Funding
- National Institutes of Health [AI40611, HL65410, AI44920, AI063400]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL065410] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI040611, R21AI063400, R01AI044920] Funding Source: NIH RePORTER
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Substantial evidence has been accumulated to indicate that gamma delta T cells take part in type 2 immune responses. It is not yet clear, however, in what capacity. Apparently, gamma delta T cells themselves can not only take the function of follicular T helper (T(H)) cells in certain responses, but also can support responses that are dependent on classical help provided by ab T cells. Furthermore, the gamma delta T cells engage as regulators of T(H2) immunity. Here, we consider two mouse models that depend on type 2 immunity, non-specific airway hyperresponsiveness to methacholine after allergen inhalation challenge and the primary IgE response induced by alum-aided immunization, and examine the function of gamma delta T cells. In either case, gamma delta T cells regulate type 2 immunity through balanced enhancing and inhibitory influences. However, after airway allergen exposure, suppressive gamma delta T cells become dominant. The underlying mechanisms are discussed. Immunology and Cell Biology (2010) 88, 269-274; doi: 10.1038/icb.2009.105; published online 26 January 2010
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