Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 86, Issue 6, Pages 530-534Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/icb.2008.17
Keywords
thymus independent; APRIL; TACI; plasma cell
Categories
Funding
- Dutch Cancer Society [UvA 2003-2812, UvA 2007-3750]
- Stichting Vanderes [150]
- Fondation de France
- Fondation pour la Recherche Medicale
- Association pour la Recherche sur le Cancer
Ask authors/readers for more resources
The tumour necrosis factor (TNF) family member a proliferation-inducing ligand (APRIL) is implicated in various B-cell processes, such as class switch recombination, plasma cell differentiation and plasma cell survival. This was suggested from initial studies analysing B-cell responses in APRIL-deficient and transgenic mice, and mice deficient for the TNF receptors of APRIL, transmembrane activator and CAML interactor (TACI) and B-cell maturation antigen. Here, we present additional evidence for the importance of APRIL in thymus-independent (TI) B-cell responses, using APRIL-deficient and transgenic mice. APRIL-deficient mice show an impaired immunoglobulin A (IgA) response towards TI B-cell antigens, whereas APRIL transgenic mice show exaggerated TI B-cell responses. Moreover, antibody titres to TI antigens were sustained in APRIL transgenic mice for a long time and even increased up to 75 days in the case of IgA against 4-hydroxy-nitrophenacetyl-lipopolysaccharide.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available