Article
Allergy
Whitney W. Stevens, Elina Jerschow, Alan P. Baptist, Larry Borish, John V. Bosso, Kathleen M. Buchheit, Katherine N. Cahill, Paloma Campo, Seong H. Cho, Anjeni Keswani, Joshua M. Levy, Anil Nanda, Tanya M. Laidlaw, Andrew A. White
Summary: AERD is characterized by chronic rhinosinusitis with nasal polyps, asthma, and intolerance to cycloxgenase-1 inhibitors, but most patients benefit from aspirin desensitization and maintenance therapy. This approach improves clinical symptoms and quality of life in AERD patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Economics
Jakub P. Hlavka, Bryan Tysinger, Jeffrey C. Yu, Darius N. Lakdawalla
Summary: Aduhelm is the first approved disease-modifying therapy for Alzheimer's disease. However, under current payment models, AD DMTs may pose challenges to patient access due to costs accruing before benefits do. New payment approaches may be needed to address this difference in timing.
Review
Biochemistry & Molecular Biology
Natasha Christabella Sutopo, Ji Hye Kim, Jae Youl Cho
Summary: This review discusses the biological and clinical relevance of histone methylation-modifying enzymes in skin cancer, specifically examining the roles of histone lysine methyltransferases, histone arginine methyltransferase, lysine-specific demethylases, and JmjC demethylases. Additionally, the efficacy of epigenetic inhibitors targeting histone methylation-modifying enzymes in cutaneous cancers such as basal cell carcinoma, squamous cell carcinoma, and melanoma is summarized. The authors propose these enzymes as novel targets for next-generation pharmaceuticals in the treatment of skin cancers and provide a rationale for developing epigenetic drugs specifically targeting histone methylases/demethylases in cutaneous tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Allergy
Jettanong Klaewsongkram, Supranee Buranapraditkun, Pungjai Mongkolpathumrat, Sirinoot Palapinyo, Hiroshi Chantaphakul
Summary: In Thailand, a significant number of patients with non-steroidal anti-inflammatory drug hypersensitivity present with symptoms in multiple organ systems. The diagnostic value of baseline uLTE4 levels is limited, but increased levels after aspirin provocation may suggest cross-reactivity with respiratory components. Aspirin desensitization may be effective in both NSAID-exacerbated respiratory disease and NSAID-induced blended reactions.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Aya A. Mabrouk, Mina Ibrahim Tadros, Wessam M. El-Refaie
Summary: Oral carcinoma is a global health threat with overexpression of COX-2 enzyme in cancer cells. COX-2 inhibitors have potential in oral cancer treatment, but their clinical efficacy is limited by poor aqueous solubility and adverse effects. Advancements in nano-drug delivery systems offer hope in overcoming these limitations and improving the efficacy of COX-2 inhibitors.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mahmood H. M. Jasim, Mohammed N. Abed, Mohannad E. Qazzaz, Mohanad Alfahad, Fawaz A. Alassaf
Summary: The study examined the potential of eight compounds in inhibiting the Cox-2 enzyme through aspirin conjugation with aromatic amino acids. Results showed that while the scores were lower than Celecoxib, these designed compounds were top ranked in solutions generated for each compound, indicating promise for the development of selective and safe Cox-2 inhibitors.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Haisheng Peng, Jiahe Wang, Jiayu Chen, Yanbo Peng, Xiaoxian Wang, Ying Chen, David L. Kaplan, Qun Wang
Summary: The rapid development of bioengineering has made it possible to use complex proteins as therapeutic agents for treating diseases. Oral delivery of proteins is a promising approach to improve patient compliance and reduce production costs. However, the gastrointestinal environment poses challenges to this delivery path, leading to reduced delivery efficiency and poor clinical outcomes.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Oncology
Ronald McDowell, Sarah Perrott, Peter Murchie, Christopher Cardwell, Carmel Hughes, Leslie Samuel
Summary: The study found that antibiotics may be associated with colon tumor formation across all age groups, while they were not associated with rectal cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Ping Wang, Yue Wang, Ping Li, Chen Chen, Siman Ma, Linxuan Zhao, Haibing He, Tian Yin, Yu Zhang, Xing Tang, Jingxin Gou
Summary: Efficient oral delivery of drugs for brain diseases is a challenging topic. Polyester nanoparticles offer solutions to this problem. This article discusses the obstacles in oral brain targeting, factors affecting brain-targeting efficiency of polyester nanoparticles, and recent strategies using oral polyester nanoparticles. The 'as a whole' strategy of polyester nanoparticles provides new insight for oral brain-targeting delivery, and combining multiple strategies improves the stability and permeability for oral brain drug delivery.
CHINESE CHEMICAL LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Balaraman Kalyanaraman
Summary: Black and Hispanic cancer patients have a higher incidence of cancer mortality. Many factors contribute to racial disparity, including socioeconomic differences and insufficient access to healthcare. Emerging research suggests that biological disparity in cancer outcomes may be related to distinct differences in the tumor immune microenvironment (TIME) and altered mitochondrial metabolism.
Review
Pharmacology & Pharmacy
Lenard M. Lichtenberger
Summary: This article describes strategies in drug development to reduce the gastrointestinal toxicity of NSAIDs. The development of PC-NSAIDs, a new family of NSAIDs associated with phosphatidylcholine that has reduced GI toxicity and full therapeutic activity, is discussed. It is shown that the stomach's hydrophobic properties, attributed to phospholipids, can be attenuated by chemically associating NSAIDs with intrinsic PC. Furthermore, pre-associating NSAIDs with PC reduces GI toxicity without affecting therapeutic activity. The commercialization and launch of Aspirin-PC, an over-the-counter drug with the brand name Vazalore (R), is also discussed.
DRUG DISCOVERY TODAY
(2023)
Article
Hematology
Takuya Harada, Hiromi Iwasaki, Tsuyoshi Muta, Shingo Urata, Aiko Sakamoto, Kentaro Kohno, Ken Takase, Tomoya Miyamura, Takuya Sawabe, Hideki Asaoku, Kensuke Oryoji, Tomoaki Fujisaki, Yasuo Mori, Goichi Yoshimoto, Masahiro Ayano, Hiroki Mitoma, Toshihiro Miyamoto, Hiroaki Niiro, Hidetaka Yamamoto, Yumi Oshiro, Hiroaki Miyoshi, Koichi Ohshima, Morishige Takeshita, Koichi Akashi, Koji Kato
Summary: The study evaluated the clinical outcomes of MTX-LPD patients and found that the pathological subtype of lymphoma could predict the clinical outcome. Patients with polymorphic-type LPD had better event-free survival compared to other subtypes. Use of TNF-alpha inhibitors was associated with higher non-relapse mortality in DLBCL patients, while RA patients previously treated with JAK inhibitors more commonly required chemotherapy, indicating disease aggressiveness.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Teymour Vahedpour, Jatinder Kaur, Salar Hemmati, Maryam Hamzeh-Mivehroud, Ali Akbar Alizadeh, Frank Wuest, Siavoush Dastmalchi
Summary: A new series of compounds for the inhibition of COX-2 were synthesized, with the lead compound showing significant COX-2 inhibition and antiproliferative activity. Molecular docking studies indicated that these compounds interact with key binding site residues of the COX-2 enzyme via multiple hydrophobic and hydrogen-bond interactions.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Medicinal
Mahmood H. M. Jasim, Mohanad Alfahad, Baraa M. Al-Dabbagh, Fawaz A. Alassaf, Mohammed N. Abed, Yasser F. Mustafa
Summary: This study aimed to synthesize and characterize five new aspirin conjugates with aromatic amino acids, and test their in vitro effects as potential selective cyclooxygenase 2 (COX-2) inhibitors. The conjugates were successfully synthesized and characterized through analysis of their H-1 and C-13 NMR and optical spectra. In vitro activity testing showed that the synthesized conjugates had lower activity than aspirin on COX-1 but higher activity on COX-2. Three of the conjugates (compounds Y1, Y3, and Y5) demonstrated comparable activity and selectivity to celecoxib. The SwissADME web tool predicted that the conjugates had high gastrointestinal absorption and better synthetic accessibility than celecoxib, and they also met the drug-likeness filters.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2023)
Editorial Material
Allergy
Ellen Minaldi, Katherine Cahill
Summary: This review provides an overview of recent studies on nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity, particularly emphasizing the importance of oral provocation tests in diagnosis and management, the varying risk of cross-reactivity to COX-2 inhibitors, and effective treatment of NSAID-exacerbated cutaneous disease. The pathophysiology, cross-reactivity, and diagnostic evaluation differ among the five distinct phenotypes of NSAID hypersensitivity, and further research is needed to understand the underlying mechanisms in patients with and without underlying disease.
CURRENT ALLERGY AND ASTHMA REPORTS
(2023)
