Article
Biochemistry & Molecular Biology
Megan Pophal, Zachary W. Grimmett, Clara Chu, Seunghee Margevicius, Thomas Raffay, Kristie Ross, Anjum Jafri, Olivia Giddings, Jonathan S. Stamler, Benjamin Gaston, James D. Reynolds
Summary: The study suggests that F-ENO could reflect airway S-nitrosothiol concentrations and serve as a biomarker for asthma. Inhalational challenge with GSNO resulted in increased F-ENO, indicating a potential non-invasive test for monitoring airway GSNO breakdown.
Review
Critical Care Medicine
Hitasha Rupani, Brian D. Kent
Summary: Asthma is a common disease with lower airway inflammation and airflow limitation. Measurement of fractional exhaled nitric oxide (FENO) can quickly assess the degree of lower airway inflammation and aid in the diagnosis, treatment guidance, and selection of appropriate biologic therapy for asthma.
Review
Biochemistry & Molecular Biology
Tommaso Pianigiani, Lorenzo Alderighi, Martina Meocci, Maddalena Messina, Beatrice Perea, Simona Luzzi, Laura Bergantini, Miriana D'Alessandro, Rosa Metella Refini, Elena Bargagli, Paolo Cameli
Summary: Through a systematic review of published articles, it was found that FeNO plays an important role as a biomarker in severe asthmatic patients undergoing biologic treatment. Higher baseline FeNO levels are associated with better clinical control and lower exacerbation rates. FeNO during biologic treatment can help predict clinical worsening and differentiate eosinophilic from non-eosinophilic exacerbations.
Article
Medicine, General & Internal
Bruna Cuoco Provenzano, Thiago Prudente Bartholo, Kennedy Martins Kirk, Mario Fritsch Neves, Marcelo Ribeiro-Alves, Ana Paula Ramos Barreto, Nadja Polisseni Graca, Paulo Roberto Chauvet Coelho, Claudia Henrique da Costa, Rogerio Rufino
Summary: Nitric oxide (NO) is produced by eosinophilic metabolism and its increase is linked with bronchial remodeling and airway hyperresponsiveness. Fractional exhaled NO (FENO) is used as a marker for eosinophilic inflammation in patients with asthma. This study found that both positive and negative bronchodilation (BD) response groups showed an increase in eosinophil count and FENO values as asthma severity increased. The correlations between FENO and eosinophils, as well as FENO values and BD+, were significant. Measuring FENO levels may help identify patients with positive BD.
Review
Allergy
Fahad Alahmadi, Adam Peel, Brian Keevil, Rob Niven, Stephen J. Fowler
Summary: Although corticosteroid treatment is effective in controlling asthma, poor adherence undermines its efficacy. Studies have used blood prednisolone levels and FeNO as markers for adherence to oral and inhaled corticosteroids, but further research is needed to assess the impact of dose and timing on blood levels and explore FeNO suppression testing in prospective studies.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Pediatrics
Yoon Young Jang, Ji Young Ahn
Summary: The study aimed to measure FeNO levels in Korean children with asthma and provide cutoff values for diagnosis. Results showed a significant correlation between FeNO levels and total immunoglobulin E. The FeNO cutoff values for the asthma group and asthma rhinitis group were 16.5 ppb and 18.5 ppb, respectively.
Article
Critical Care Medicine
Sumita B. Khatri, Jonathan M. Iaccarino, Amisha Barochia, Israa Soghier, Praveen Akuthota, Anna Brady, Ronina A. Covar, Jason S. Debley, Zuzana Diamant, Anne M. Fitzpatrick, David A. Kaminsky, Nicholas J. Kenyon, Sandhya Khurana, Brian J. Lipworth, Kevin McCarthy, Michael Peters, Loretta G. Que, Kristie R. Ross, Elena K. Schneider-Futschik, Christine A. Sorkness, Teal S. Hallstrand
Summary: The FENO test is a useful tool in assessing asthma patients, and based on the latest evidence a recommendation has been made that using FENO in patients under consideration for treatment may be beneficial and should be used in conjunction with standard care.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Natasa Karamarkovic Lazarusic, Eugenija Kasap Basioli, Ena Tolic, Martina Dokoza, Gordana Pavlisa
Summary: This study evaluated the diagnostic accuracy of fractional exhaled nitric oxide (FeNO) in mild asthma and found that FeNO has insufficient sensitivity and specificity in this condition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Sumita B. Khatri, Jonathan M. Laccarino, Amisha Barochia, Israa Soghier, Praveen Akuthota, Anna Brady, Ronina A. Covar, Jason S. Debley, Zuzana Diamant, Anne M. Fitzpatrick, David A. Kaminsky, Nicholas J. Kenyon, Sandhya Khurana, Brian J. Lipworth, Kevin McCarthy, Michael Peters, Loretta G. Que, Kristie R. Ross, Elena K. Schneider-Futschik, Christine A. Sorkness, Teal S. Hallstrand
Summary: The study suggests that using fractional exhaled nitric oxide (FENO) testing is beneficial in patients with asthma in whom treatment is being considered, and is recommended for use in addition to usual care. This recommendation is based on overall low quality evidence, but the panel believes that FENO can optimize asthma treatment.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Denis Vinnikov, Zhangir Tulekov, Paul D. Blanc
Summary: In a metalworking industrial cohort, welders/assemblers exhibited significantly higher levels of FeNO. This may indicate respiratory tract inflammation associated with airborne exposures specific to this group.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2022)
Article
Allergy
J. A. Buendia, R. Acuna-Cordero, C. E. Rodriguez-Martinez
Summary: This study evaluated the budget impact of asthma management using FeNO monitoring in Colombia. The findings showed that adopting FeNO for routine management in patients with persistent asthma could lead to cost savings for the Colombian National Health System.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Pediatrics
Liang-Mei Lin, Yu-Jun Chang, Kuender D. Yang, Ching-Hsiung Lin, Jien-Wen Chien, Jun-Kai Kao, Ming-Sheng Lee, Tsay- Chiang, Ching-Yuang Lin, Yi-Giien Tsai
Summary: This study aimed to investigate the utility of IOS and FeNO for assessing childhood asthma control in terms of small airway dysfunction and airway inflammation.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Isaac Ikwu, Louis Gardy Nicolas, Alem Mehari, Richard F. Gillum
Summary: This study found that a Fractional concentration of exhaled Nitric Oxide (FeNO) level of 25 ppb or higher was associated with a reduced risk of mortality in patients with asthma and no history of emergency department visits in the previous year. However, there was no significant association between FeNO and mortality in patients with chronic obstructive pulmonary disease (COPD).
RESPIRATORY MEDICINE
(2022)
Review
Allergy
Claire A. Butler, Liam G. Heaney
Summary: High FeNO levels in asthmatic patients indicate an increased risk of exacerbation, often due to suboptimal adherence to inhaled corticosteroid treatment. Monitoring FeNO response and adherence can help prevent unnecessary escalation to biologic therapy in difficult-to-control asthma patients with Type-2 biomarker high.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Christina Kellerer, Stefan Wagenpfeil, Luke Daines, Rudolf A. Joerres, Alexander Hapfelmeier, Antonius Schneider
Summary: This study aimed to assess the impact of different reference standards on the accuracy of asthma diagnosis, finding that when using whole-body plethysmography, fractional exhaled nitric oxide and certain clinical signs and symptoms showed higher specificity. In conclusion, superior reference standards led to more favorable assessments of index tests for asthma diagnosis.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
