Estimation of polyclonal IgG4 hybrids in normal human serum

Fab-arm exchange

(2012) Janine Schuurman et al.   mAbs

Fab-arm exchange is a misnomer

(2012) Janardan P. Pandey   mAbs

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Crystal structure of the human IgG4 CH3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange

(2012) Anna M. Davies et al.   MOLECULAR IMMUNOLOGY

Fc–Fc interactions of human IgG4 require dissociation of heavy chains and are formed predominantly by the intra-chain hinge isomer

(2012) Theo Rispens et al.   MOLECULAR IMMUNOLOGY

IgG4-Related Disease

(2012) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

(2011) A. F. Labrijn et al.   JOURNAL OF IMMUNOLOGY

Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4

(2011) Renée I. Shapiro et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Mechanism of Immunoglobulin G4 Fab-arm Exchange

(2011) Theo Rispens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Autoimmune pancreatitis and IgG4-related sclerosing cholangitis

(2010) Kensuke Takuma et al.   CURRENT OPINION IN RHEUMATOLOGY

What is IgG4? A review of the biology of a unique immunoglobulin subtype

(2010) Ajay Nirula et al.   CURRENT OPINION IN RHEUMATOLOGY

Hybrid IgG4/IgG4 Fc antibodies form upon ‘Fab-arm’ exchange as demonstrated by SDS-PAGE or size-exclusion chromatography

(2010) Theo Rispens et al.   MOLECULAR IMMUNOLOGY

Immunoglobulin G4: an odd antibody

(2009) R. C. Aalberse et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Assessment of Monoclonal Gammopathies by Nephelometric Measurement of Individual Immunoglobulin  /  Ratios

(2009) A. R. Bradwell et al.   CLINICAL CHEMISTRY

Stress-Free Chromatography: Affinity Chromatography

(2009) Tsutomu Arakawa et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Impact of Molecular Processing in the Hinge Region of Therapeutic IgG4 Antibodies on Disposition Profiles in Cynomolgus Monkeys

(2009) K. Stubenrauch et al.   DRUG METABOLISM AND DISPOSITION

Comparison of the ability of wild type and stabilized human IgG4 to undergo Fab arm exchange with endogenous IgG4 in vitro and in vivo

(2009) Kenneth B. Lewis et al.   MOLECULAR IMMUNOLOGY

The in vitro biological activity of the HLA-DR-binding clinical IgG4 antibody 1D09C3 is a consequence of the disruption of cell aggregates and can be abrogated by Fab arm exchange

(2009) Kerrin Hansen et al.   MOLECULAR IMMUNOLOGY

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY