Article
Immunology
Viktoryia Laurynenka, Lili Ding, Kenneth M. Kaufman, Judith A. James, John B. Harley
Summary: The association between EBV infection and SLE is reconfirmed, and the presence of anti-EBNA1 antibodies in SLE cases is more frequent than in EBV-infected controls, supporting the hypothesis that anti-EBNA1 contributes to SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Alessio Buonavoglia, Patrizia Leone, Marcella Prete, Antonio Giovanni Solimando, Chiara Guastadisegno, Gianvito Lanave, Michele Camero, Vito Martella, Lorenzo Lo Muzio, Vito Racanelli
Summary: This study reveals a significant association between EBV and both SLE and SLE-related oral lesions, providing a basis for further investigation into the role of EBV in SLE pathogenesis. The detection rate of EBV varies among different populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Xiaoying Shang, Lisheng Ren, Guirong Sun, Teng Yu, Yuan Yao, Lin Wang, Fenghai Liu, Lijun Zhang, Xiaqin He, Mingjun Liu
Summary: The study showed that anti-C1q, anti-dsDNA, anti-Nucleosome, and anti-Histone antibodies are valuable in diagnosing active lupus nephritis and monitoring systemic lupus erythematosus disease activity. These antibodies correlated positively with SLE disease activity index, with anti-Nucleosome showing the highest correlation coefficient. The levels of these antibodies decreased following treatment and the changes were positively correlated with SLE disease activity index variations.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Fang Zhang, Baokai Zhang, Huihua Ding, Xiangyue Li, Xilin Wang, Xiaomin Zhang, Qiaojie Liu, Qiuyun Feng, Mingshun Han, Longlong Chen, Linlin Qi, Dan Yang, Xiaojing Li, Xingguo Zhu, Qi Zhao, Jiaqian Qiu, Zhengjiang Zhu, Huiru Tang, Nan Shen, Hongyan Wang, Bin Wei
Summary: Systemic lupus erythematosus (SLE) is associated with abnormal lipid and cholesterol metabolism, as well as type I interferon (IFN-I) signaling. An analysis reveals increased levels of 7α,25-dihydroxycholesterol (7α,25-OHC) in SLE patients, which binds to its receptor EBI2 in macrophages and suppresses immune activation. EBI2-deficient macrophages produce higher levels of chemokines and cytokines, exacerbating SLE. This study highlights the potential of targeting the EBI2 pathway for diagnostic and therapeutic purposes in SLE.
Article
Immunology
Yingxin Dai, Enling Li, Dandan Chen, Xiangyu Niu, Zhiqing Wang, Liangjing Lu, Bing Zheng
Summary: Monospecific autoantibodies to dense fine speckles 70 (DFS70) antigen are prevalent in Chinese SLE patients and are positively associated with anti-dsDNA. There is consistent dynamic variation between anti-DFS70 and anti-dsDNA during follow-up.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Neelakshi R. Jog, Judith A. James
Summary: Infections or infectious reactivation can trigger systemic lupus erythematosus (SLE), and Epstein-Barr virus (EBV) is associated with various autoimmune diseases, including SLE. Recent advances suggest that EBV may play a role in immune dysregulation and its relationship to SLE disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Adrian Y. S. Lee
Summary: This review article summarizes the current knowledge of the IgA isotype of anti-double-stranded DNA autoantibodies in systemic lupus erythematosus, focusing on its clinical associations and potential links with lupus nephritis.
Article
Multidisciplinary Sciences
Deborah K. Johnson, Kaylia M. Reynolds, Brian D. Poole, Matthew D. Montierth, Vera M. Todd, April Barnado, Mary F. Davis
Summary: Patients with autoimmune disorders have altered cancer risks compared to the general population, with a strong association between viral infection and increased cancer risk. SLE and MS patients are more susceptible to viral infections, and preventing viral infections through vaccination may help control cancer risk for these patients.
Article
Immunology
Melissa E. Munroe, Jourdan R. Anderson, Timothy F. Gross, Laura L. Stunz, Gail A. Bishop, Judith A. James
Summary: This study explores the impact of the EBV molecular mimic EBNA-1 on disease-specific autoimmunity, finding that mCD40-LMP1 transgenic mice exhibit enhanced cellular and humoral immune responses after EBNA-1 immunization, suggesting an interaction between LMP1 and EBNA-1 that increases immune dysregulation leading to pathogenic, autoantigen-specific lupus inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Jing Han, Zhuochao Zhou, Rongrong Zhang, Yijun You, Zizhen Guo, Jinyan Huang, Fan Wang, Yue Sun, Honglei Liu, Xiaobing Cheng, Yutong Su, Hui Shi, Qiongyi Hu, Jialin Teng, Chengde Yang, Shifang Ren, Junna Ye
Summary: This study found that the glycosylation of anti-dsDNA IgG was different from that of total IgG, and fucosylation of anti-dsDNA IgG1 correlated best with SLE disease activity.
Article
Virology
Xiaotong Chen, Hui Li, Chunling Wu, Yan Zhang
Summary: This study suggests that EBV infection may be related to the occurrence of SLE, while HHV-6 infection may not have a direct association with the development of SLE. However, in SLE patients, EBV and HHV-6 infection may have a coacceleration effect.
Article
Immunology
Ana Banko, Andja Cirkovic, Rada Miskovic, Ivica Jeremic, Milka Grk, Milica Basaric, Ivana Lazarevic, Sanvila Raskovic, Aleksa Despotovic, Danijela Miljanovic
Summary: The study found that there is a significant association between EBV infection and SLE development. Anti-EBV-EA(D) IgG antibodies were shown to increase the possibility of having SLE by 24 times in SLE patients. Higher titers of anti-EBV-EA(D) IgG antibodies were associated with lymphopenia and hematological SLE manifestation. Furthermore, novel data on EBV EBNA1 and LMP1 gene polymorphisms in lupus were reported.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Anna Hedenstedt, Sarah Reid, Ahmed Sayadi, Maija-Leena Eloranta, Elisabeth Skoglund, Karin Bolin, Martina Frodlund, Karoline Lerang, Andreas Joensen, Solbritt Rantapaeae-Dahlqvist, Anders A. Bengtsson, Anna Rudin, Oyvind Molberg, Christopher Sjoewall, Johanna K. Sandling, Dag Leonard
Summary: This study found that the genetic burden related to B cell function is associated with dsDNA antibody development and lupus nephritis in SLE patients.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Medicine, General & Internal
Keiichiro Kadoba, Keisuke Nishimura, Kaori Uchino, Daisuke Waki, Hiroyuki Murabe, Toshihiko Yokota
Summary: This case report describes an age-related EBV-LPD mimicking SLE in elderly patients without immunodeficiency. Therefore, EBV-related disorders should be considered in the differential diagnosis of SLE even in the elderly population.
Review
Virology
Marco Quaglia, Guido Merlotti, Marco De Andrea, Cinzia Borgogna, Vincenzo Cantaluppi
Summary: There is a causal link between viral infections and systemic lupus erythematosus (SLE), with viruses such as Epstein-Barr virus, parvovirus B19, and human endogenous retroviruses playing a role in SLE pathogenesis. Viruses impact SLE development through mechanisms like molecular mimicry, epitope spreading, and activation of innate immune response. Understanding these mechanisms may lead to new therapeutic perspectives for SLE.