CD4+ T helper 2 cells - microbial triggers, differentiation requirements and effector functions

Suppression of Th2 Cell Development by Notch Ligands Delta1 and Delta4

(2014) J. Sun et al.   JOURNAL OF IMMUNOLOGY

Th1 and Th2 Cells Form Morphologically Distinct Immunological Synapses

(2014) T. J. Thauland et al.   JOURNAL OF IMMUNOLOGY

IL-33 Induces Antigen-Specific IL-5+ T Cells and Promotes Allergic-Induced Airway Inflammation Independent of IL-4

(2014) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Narrative Review: The Role of Th2 Immune Pathway Modulation in the Treatment of Severe Asthma and Its Phenotypes

(2013) Stewart J. Levine   ANNALS OF INTERNAL MEDICINE

Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-κB pathway in mast cells

(2011) Phil-Dong Moon et al.   CYTOKINE

Type 2 innate immune responses and the natural helper cell

(2011) Shigeo Koyasu et al.   IMMUNOLOGY

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation

(2011) Jennifer Louten et al.   INTERNATIONAL IMMUNOLOGY

An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation

(2011) R. Yagi et al.   INTERNATIONAL IMMUNOLOGY

Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

(2011) Xiuju Dai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic Stromal Lymphopoietin Is Produced by Dendritic Cells

(2011) M. Kashyap et al.   JOURNAL OF IMMUNOLOGY

Th2 Responses to Helminth Parasites Can Be Therapeutically Enhanced by, but Are Not Dependent upon, GITR-GITR Ligand Costimulation In Vivo

(2011) N. van der Werf et al.   JOURNAL OF IMMUNOLOGY

The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

(2011) Hideaki Kouzaki et al.   JOURNAL OF IMMUNOLOGY

Basophils Are the Major Producers of IL-4 during Primary Helminth Infection

(2011) N. van Panhuys et al.   JOURNAL OF IMMUNOLOGY

Genetic analysis of basophil function in vivo

(2011) Brandon M Sullivan et al.   NATURE IMMUNOLOGY

Nuocytes and beyond: new insights into helminth expulsion

(2011) Daniel R. Neill et al.   TRENDS IN PARASITOLOGY

Thymic stromal lymphopoietin

(2010) Rui He et al.   Annals of the New York Academy of Sciences

Helminths and dendritic cells: Sensing and regulating via pattern recognition receptors, Th2 and Treg responses

(2010) Bart Everts et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Basophils Orchestrate Chronic Allergic Dermatitis and Protective Immunity against Helminths

(2010) Caspar Ohnmacht et al.   IMMUNITY

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

(2010) Ahmed N. Hegazy et al.   IMMUNITY

T-cell polarization depends on concentration of the danger signal used to activate dendritic cells

(2010) Marcus Peters et al.   IMMUNOLOGY AND CELL BIOLOGY

CD11c depletion severely disrupts Th2 induction and development in vivo

(2010) Alexander T. Phythian-Adams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

(2010) Hamida Hammad et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel subset of CD4+TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma

(2010) Yui-Hsi Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

(2010) John R. Grainger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch Ligand Delta-Like 4 Regulates Development and Pathogenesis of Allergic Airway Responses by Modulating IL-2 Production and Th2 Immunity

(2010) S. Jang et al.   JOURNAL OF IMMUNOLOGY

Critical Role of IL-25 in Nematode Infection-Induced Alterations in Intestinal Function

(2010) A. Zhao et al.   JOURNAL OF IMMUNOLOGY

Protease Allergens Induce the Expression of IL-25 via Erk and p38 MAPK Pathway

(2010) Hak Sun Yu et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

(2010) Steven A. Saenz et al.   NATURE

Regulation of IL-9 expression by IL-25 signaling

(2010) Pornpimon Angkasekwinai et al.   NATURE IMMUNOLOGY

Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node

(2010) Georgia Perona-Wright et al.   NATURE IMMUNOLOGY

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling

(2010) Hua Tang et al.   NATURE IMMUNOLOGY

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses

(2009) Y.-H. Wang et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Signals for the execution of Th2 effector function

(2009) Deborah J. Fowell   CYTOKINE

IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes

(2009) Neil E. Humphreys et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Omega-1, a glycoprotein secreted bySchistosoma mansonieggs, drives Th2 responses

(2009) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

(2009) Svenja Steinfelder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Basophils Are Transiently Recruited into the Draining Lymph Nodes during Helminth Infection via IL-3, but Infection-Induced Th2 Immunity Can Develop without Basophil Lymph Node Recruitment or IL-3

(2009) S. Kim et al.   JOURNAL OF IMMUNOLOGY

Regulation of Helminth-Induced Th2 Responses by Thymic Stromal Lymphopoietin

(2009) Thirumalai R. Ramalingam et al.   JOURNAL OF IMMUNOLOGY

IL-33 Activates Unprimed Murine Basophils Directly In Vitro and Induces Their In Vivo Expansion Indirectly by Promoting Hematopoietic Growth Factor Production

(2009) E. Schneider et al.   JOURNAL OF IMMUNOLOGY

IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38α-dependent pathway

(2009) Kelly M. Kroeger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide–MHC class II complexes to CD4+ T cells

(2009) Tomohiro Yoshimoto et al.   NATURE IMMUNOLOGY

MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunity

(2009) Jacqueline G Perrigoue et al.   NATURE IMMUNOLOGY

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

(2009) Caroline L Sokol et al.   NATURE IMMUNOLOGY

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

(2009) S. Z. Ben-Sasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function

(2009) J. C. Massacand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

(2009) L. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signaling and immune modulation at the schistosome surface?

(2009) Rita Bhardwaj et al.   TRENDS IN PARASITOLOGY

The danger within: endogenous danger signals, atopy and asthma

(2008) M. A. M. Willart et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Dendritic cell expression of the Notch ligandjagged2 is not essential for Th2 response inductionin vivo

(2008) Alan G. F. Worsley et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

(2008) Y. Kondo et al.   INTERNATIONAL IMMUNOLOGY

Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction

(2008) Francesco Liotta et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A

(2008) Justyna Rzepecka et al.   MOLECULAR IMMUNOLOGY

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

(2008) Aurelien Trompette et al.   NATURE

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation

(2008) N. van Panhuys et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA