Mechanisms regulating chemokine receptor activity

The Chemokine Receptor CXCR3 Is Degraded following Internalization and Is Replenished at the Cell Surface by De Novo Synthesis of Receptor

(2014) A. Meiser et al.   JOURNAL OF IMMUNOLOGY

Arrestin 3 Mediates Endocytosis of CCR7 following Ligation of CCL19 but Not CCL21

(2014) M. A. Byers et al.   JOURNAL OF IMMUNOLOGY

Endogenous Ligand Bias by Chemokines: Implications at the Front Lines of Infection and Leukocyte Trafficking

(2012) David A. Zidar   Endocrine Metabolic & Immune Disorders-Drug Targets

CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection

(2011) Mieke Gouwy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCR4 Expression on Activated B Cells Is Downregulated by CD63 and IL-21

(2011) N. Yoshida et al.   JOURNAL OF IMMUNOLOGY

TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes

(2010) J. M. Fox et al.   BLOOD

Beta-arrestins as regulators of signal termination and transduction: How do they determine what to scaffold?

(2010) Kathryn A. DeFea   CELLULAR SIGNALLING

Na+/H+Exchanger Regulatory Factor-1 Is Involved in Chemokine Receptor Homodimer CCR5 Internalization and Signal Transduction but Does Not Affect CXCR4 Homodimer or CXCR4-CCR5 Heterodimer

(2010) Maha M. Hammad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CC Chemokine Receptor 5 (CCR5) Desensitization

(2010) Jean-Michel Escola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases

(2010) Qihong Zhao   JOURNAL OF LEUKOCYTE BIOLOGY

Arrestin-2 Interacts with the Endosomal Sorting Complex Required for Transport Machinery to Modulate Endosomal Sorting of CXCR4

(2010) Rohit Malik et al.   MOLECULAR BIOLOGY OF THE CELL

Different Effects of the Different Natural CC Chemokine Receptor 2b Ligands on  -Arrestin Recruitment, G i Signaling, and Receptor Internalization

(2010) Y. A. Berchiche et al.   MOLECULAR PHARMACOLOGY

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

(2010) N. J. Smith et al.   PHARMACOLOGICAL REVIEWS

Chemokine receptors intracellular trafficking

(2010) Elena M. Borroni et al.   PHARMACOLOGY & THERAPEUTICS

Filamin A Binds to CCR2B and Regulates Its Internalization

(2010) Laura Minsaas et al.   PLoS One

A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration

(2009) C. S. McKimmie et al.   BLOOD

Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2

(2009) M.A. García Lopez et al.   CELLULAR SIGNALLING

Chemokine receptor oligomerization: functional considerations

(2009) Marcus Thelen et al.   CURRENT OPINION IN PHARMACOLOGY

Molecular integration via allosteric interactions in receptor heteromers. A working hypothesis

(2009) Kjell Fuxe et al.   CURRENT OPINION IN PHARMACOLOGY

Chemokine receptor antagonists: part 2

(2009) James E Pease et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Chemokine receptor antagonists: Part 1

(2009) James E Pease et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists

(2009) Denis Sohy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Regulation of CXCR1 and CXCR2 Homo- and Heterodimers

(2009) L. Martinez Munoz et al.   JOURNAL OF IMMUNOLOGY

Amyloid   Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier

(2009) M. Li et al.   JOURNAL OF IMMUNOLOGY

Pertussis Toxin Signals through the TCR to Initiate Cross-Desensitization of the Chemokine Receptor CXCR4

(2009) O. D. Schneider et al.   JOURNAL OF IMMUNOLOGY

CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8

(2009) Mieke Gouwy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

N-linked glycan-dependent interaction of CD63 with CXCR4 at the Golgi apparatus induces downregulation of CXCR4

(2009) Takeshi Yoshida et al.   MICROBIOLOGY AND IMMUNOLOGY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

(2009) J. C. Alves-Filho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

(2008) Geraldine Parenty et al.   BIOCHEMICAL JOURNAL

CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface

(2008) L. Achour et al.   BLOOD

Modulation of chemokine receptor activity through dimerization and crosstalk

(2008) C. L. Salanga et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CCR5 internalisation and signalling have different dependence on membrane lipid raft integrity

(2008) Clara Moyano Cardaba et al.   CELLULAR SIGNALLING

Dimerization of chemokine receptors in living cells: key to receptor function and novel targets for therapy

(2008) Jinhai Wang et al.   DRUG DISCOVERY TODAY

Ligand stabilization of CXCR4/δ-opioid receptor heterodimers reveals a mechanism for immune response regulation

(2008) Oscar M. Pello et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation

(2008) Marjelo A. Mines et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Carboxyl-terminal PDZ Ligand Motif of Chemokine Receptor CXCR2 Modulates Post-endocytic Sorting and Cellular Chemotaxis

(2008) Paige J. Baugher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bi-directional heterologous desensitization between the major HIV-1 co-receptor CXCR4 and the κ-opioid receptor

(2008) Matthew J. Finley et al.   JOURNAL OF NEUROIMMUNOLOGY

Synergy between Coproduced CC and CXC Chemokines in Monocyte Chemotaxis through Receptor-Mediated Events

(2008) M. Gouwy et al.   MOLECULAR PHARMACOLOGY

The Duffy Antigen/Receptor for Chemokines Exists in an Oligomeric Form in Living Cells and Functionally Antagonizes CCR5 Signaling through Hetero-Oligomerization

(2008) A. Chakera et al.   MOLECULAR PHARMACOLOGY

Chemokine receptor antagonists: overcoming developmental hurdles

(2008) Richard Horuk   NATURE REVIEWS DRUG DISCOVERY

Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors

(2008) Nilgun Isik et al.   PLoS One

CXCR4-CCR5: A couple modulating T cell functions

(2008) R. L. Contento et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function

(2008) G. Hajishengallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CD63 Mutant Inhibits T-cell Tropic Human Immunodeficiency Virus Type 1 Entry by Disrupting CXCR4 Trafficking to the Plasma Membrane

(2008) Takeshi Yoshida et al.   TRAFFIC

Conformational changes involved in G-protein-coupled-receptor activation

(2008) Jürgen Wess et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

G Protein–Coupled Receptor Sorting to Endosomes and Lysosomes

(2007) Adriano Marchese et al.   Annual Review of Pharmacology and Toxicology