Article
Immunology
Lisa Kornstaedt, Sandra Pierre, Andreas Weigert, Stefanie Ebersberger, Tim J. Schaeufele, Anja Kolbinger, Tobias Schmid, Jennifer Cohnen, Dominique Thomas, Nerea Ferreiros, Bernhard Bruene, Ingo Ebersberger, Klaus Scholich
Summary: Mast cells play a role in the resolution phase of inflammation by producing mediators like IFN-beta that regulate macrophage phagocytosis. Deficiency in mast cells can result in decreased efferocytosis and phagocytosis during the resolution of inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jinzhao Ou, Meng Zhu, Xiaoyan Ju, Dandan Xu, Guojun Lu, Kejia Li, Wei Jiang, Chenxiao Wan, Yuexia Zhao, Yongping Han, Ye Tian, Zhongwei Niu
Summary: The phenotype of tumor-associated macrophages is crucial in regulating the tumor immune microenvironment. Tobacco mosaic virus (TMV), a rod-like plant virus, can polarize macrophages to an M1 phenotype and create a tumor-suppressive microenvironment.
Review
Immunology
Kensuke Miyake, Takuma Shibata, Ryutaro Fukui, Ryota Sato, Shin-Ichiroh Saitoh, Yusuke Murakami
Summary: Toll-like receptors (TLRs) respond to pathogen constituents by recognizing and degrading nucleic acids with the help of nucleases. However, these nucleases also negatively regulate TLR responses by degrading ligands. Dysregulation of nucleic acid metabolism in endosomal compartments drives TLR-dependent pathologies in human diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Emma J. Keller, Neeva B. Patel, Madeline Patt, Jane K. Nguyen, Trine N. Jorgensen
Summary: Research indicates that in SLE patients, IFN alpha beta signaling in B cells leads to splenomegaly, increased populations of activated B cells, germinal center B cells, memory B cells, and plasma blasts/cells, while not affecting the development of glomerulonephritis and immune-complex deposition.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xin Zhang, Xiulin Lin, Hui Luo, Yuanxing Zhi, Xin Yi, Xiaoyan Wu, Wendi Duan, Ying Cao, Jianxin Pang, Shuwen Liu, Pingzheng Zhou
Summary: Potassium efflux mediated by the Kv1.3 channel plays a critical role in TLR3/4 activation, and pharmacological inhibition of Kv1.3 may be beneficial for treating autoimmune diseases and bacterial infections.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Bo-Ram Jo, Hyun-Soo Kim, Jeong-Won Ahn, Eui-Young Jeoung, Su-Kil Jang, Yeong-Min Yoo, Seong-Soo Joo
Summary: Pathogenesis-related (PR) proteins in plants play a crucial role in plant defense against microbial attacks. In this study, a novel PR-1-like protein (OPRP) was identified and its pharmacologic relevance and cell signaling in mammalian cells were examined. The purified full-length OPRP protein increased the expression levels of genes involved in the immune response, while small peptides designed from OPRP upregulated antiviral genes in mouse splenocytes and human epithelial cells. OPRP and its small peptides activated specific signaling pathways and inhibited viral entry into host cells.
Review
Medicine, Research & Experimental
Xiao Li, Xinyuan Sun, Xuemin Guo, Xueren Li, Shouchun Peng, Xin Mu
Summary: Nucleic acid-mediated interferon signaling plays a pivotal role in defense against microorganisms, especially during viral infection. This article discusses the receptors involved in sensing nucleic acid molecules, their structures and functions, and the importance of their proper functioning in cell homeostasis and response to pathogen invasion. It also explores the impact of manipulating these receptors on defense mechanisms and presents the discovery of chemicals that can modulate their signaling activities.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Kevin Alicea-Torres, Emilio Sanseviero, Jun Gui, Jinyun Chen, Filippo Veglia, Qiujin Yu, Laxminarasimha Donthireddy, Andrew Kossenkov, Cindy Lin, Shuyu Fu, Charles Mulligan, Brian Nam, Gregory Masters, Fred Denstman, Joseph Bennett, Neil Hockstein, Agnieszka Rynda-Apple, Yulia Nefedova, Serge Y. Fuchs, Dmitry Gabrilovich
Summary: Type I interferon receptor signaling serves as a universal mechanism restricting MDSC suppressive activity, with downregulation of IFNAR1 required for activation of immune suppressive properties in MDSC. Modulating IFNAR1 undermines MDSC suppressive activity and has potent anti-tumor effects.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jorn E. Stok, Timo Oosenbrug, Laurens R. ter Haar, Dennis Gravekamp, Christian P. Bromley, Santiago Zelenay, Caetano Reis e Sousa, Annemarthe G. van der Veen
Summary: This study reveals the crucial role of LGP2 in inducing a type I interferon response in ADAR1-deficient cells. In addition, the sensitivity of tumor cells to ADAR1 loss is dependent on LGP2 expression.
Article
Microbiology
Jun Kang, Mengqian Huang, Jinyu Li, Keke Zhang, Cheng Zhu, Sihua Liu, Zhenwei Zhou, Tao Wang, Zhiyun Wang
Summary: EV-D68 is a globally emerging pathogen causing severe respiratory illnesses mainly in children. The structural protein VP3 of EV-D68 interacts with IRF7 and inhibits its phosphorylation and nuclear translocation, resulting in the repression of IFN production. VP3 also inhibits the ubiquitination of IRF7 induced by TRAF6 through competitive interaction. The control of IRF7 by VP3 may contribute to the subversion of host innate immune responses by EV-D68.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Supeng Yin, Mengmeng Yuan, Sirui Zhang, Hongdan Chen, Jing Zhou, Tongyu He, Gang Li, Yanlan Yu, Fan Zhang, Ming Li, Yan Zhao
Summary: This study reveals that SspA-1 from the highly virulent Streptococcus suis 2 strain induces excessive inflammatory response through TLR2 endosomal and type I IFN signaling, uncovering a novel role of type I IFN in S. suis infection.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Wenjun Shao, Yue Huang, Lili Wang, Penghui Li, Yan Jia, Jiewen Zhang
Summary: The study found that Fgl2 can alleviate the symptoms and damage of autoimmune myelitis by reducing TLR9 expression, indicating its potential role in the treatment of autoimmune diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Bo Li, Min Lian, Yikang Li, Qiwei Qian, Jun Zhang, Qiaoyan Liu, Ruqi Tang, Xiong Ma
Summary: The study found that upregulation of LXR alpha in patients with autoimmune hepatitis can promote the expansion of MDSCs and alleviate hepatic injury. By downregulating IRF-8, LXR alpha plays an important role in MDSCs, providing a new approach to treating AIH.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jen-Chih Tseng, Yung-Chi Chang, Chun-Ming Huang, Li-Chung Hsu, Tsung-Hsien Chuang
Summary: Psoriasis is a complex inflammatory autoimmune skin disorder affecting 2-3% of the global population, mainly influenced by genetic and environmental factors, with current treatments focusing on immune responses. While biologics have shown better efficacy and safety in alleviating symptoms, psoriasis remains incurable.
Article
Biochemistry & Molecular Biology
Jincai Wen, Wenqing Mu, Hui Li, Yulu Yan, Xiaoyan Zhan, Wei Luo, Zhongxia Wang, Wen Kan, Jia Zhao, Siwen Hui, Ping He, Shuanglin Qin, Yingjie Xu, Ping Zhang, Xiaohe Xiao, Guang Xu, Zhaofang Bai
Summary: The cGAS-STING signaling pathway plays a crucial role in the natural immune system. Abnormal activation of this pathway has been strongly linked to the development and progression of autoimmune diseases. Glabridin, a major component of licorice, has been found to specifically inhibit this pathway by reducing the levels of type I interferon and inflammatory cytokines. It also shows therapeutic effects on innate immune diseases caused by abnormal cytoplasmic DNA in Trex1-deficient mice. Glabridin may be a potential candidate for clinical therapy in autoimmune diseases mediated by the cGAS-STING pathway.
MOLECULAR MEDICINE
(2023)
