Journal
IMMUNOLOGICAL REVIEWS
Volume 261, Issue 1, Pages 50-61Publisher
WILEY
DOI: 10.1111/imr.12207
Keywords
histone modification; T cell; gene expression; epigenetic
Categories
Funding
- National Health and Medical Research Council of Australia [APP1049307]
- American Asthma Foundation
- Australian Research Council Future Fellowships
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The multiple lineages and differentiation states that constitute the T-cell compartment all derive from a common thymic precursor. These distinct transcriptional states are maintained both in time and after multiple rounds of cell division by the concerted actions of a small set of lineage-defining transcription factors that act in conjunction with a suite of chromatin-modifying enzymes to activate, repress, and fine-tune gene expression. These chromatin modifications collectively provide an epigenetic code that allows the stable and heritable maintenance of the T-cell phenotype. Recently, it has become apparent that the epigenetic code represents a therapeutic target for a variety of immune cell disorders, including lymphoma and acute and chronic inflammatory diseases. Here, we review the recent advances in epigenetic regulation of gene expression, particularly as it relates to the T-cell differentiation and function.
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