Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm

Th1 and Th2 Cells Form Morphologically Distinct Immunological Synapses

(2014) T. J. Thauland et al.   JOURNAL OF IMMUNOLOGY

The cytoplasm of living cells behaves as a poroelastic material

(2013) Emad Moeendarbary et al.   NATURE MATERIALS

Calcium Regulation of Myosin-I Tension Sensing

(2012) John H. Lewis et al.   BIOPHYSICAL JOURNAL

Active Remodeling of Cortical Actin Regulates Spatiotemporal Organization of Cell Surface Molecules

(2012) Kripa Gowrishankar et al.   CELL

Organization of the resting TCR in nanoscale oligomers

(2012) Wolfgang W. A. Schamel et al.   IMMUNOLOGICAL REVIEWS

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

Characterization of dynamic actin associations with T-cell receptor microclusters in primary T cells

(2012) A. A. Smoligovets et al.   JOURNAL OF CELL SCIENCE

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Integration of the movement of signaling microclusters with cellular motility in immunological synapses

(2012) Peter Beemiller et al.   NATURE IMMUNOLOGY

Myosin IIA Modulates T Cell Receptor Transport and CasL Phosphorylation during Early Immunological Synapse Formation

(2012) Yan Yu et al.   PLoS One

T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse

(2012) Sudha Kumari et al.   Frontiers in Immunology

The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling

(2011) R. Calvez et al.   HAEMATOLOGICA

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

(2011) Eilon Sherman et al.   IMMUNITY

Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes

(2011) Rashmi Kumar et al.   IMMUNITY

Vav1-Mediated Scaffolding Interactions Stabilize SLP-76 Microclusters and Contribute to Antigen-Dependent T Cell Responses

(2011) N. R. Sylvain et al.   Science Signaling

Diversity in immunological synapse structure

(2010) Timothy J. Thauland et al.   IMMUNOLOGY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

Myosin II contributes to cell-scale actin network treadmilling through network disassembly

(2010) Cyrus A. Wilson et al.   NATURE

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Illuminating emergent activity in the immune system by real-time imaging

(2010) Matthew F Krummel   NATURE IMMUNOLOGY

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA–regulated adhesions

(2010) Jordan Jacobelli et al.   NATURE IMMUNOLOGY

Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation

(2009) Kaushik Choudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells

(2009) Yoshihisa Kaizuka et al.   JOURNAL OF CELL BIOLOGY

Animal cell hydraulics

(2009) G. T. Charras et al.   JOURNAL OF CELL SCIENCE

Myosin-IIA and ICAM-1 Regulate the Interchange between Two Distinct Modes of T Cell Migration

(2009) J. Jacobelli et al.   JOURNAL OF IMMUNOLOGY

Intracellular fluid flow in rapidly moving cells

(2009) Kinneret Keren et al.   NATURE CELL BIOLOGY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

T cell antigen receptor signaling and immunological synapse stability require myosin IIA

(2009) Tal Ilani et al.   NATURE IMMUNOLOGY

Cluster size regulates protein sorting in the immunological synapse

(2009) N. C. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Receptor Microcluster Transport through Molecular Mazes Reveals Mechanism of Translocation

(2008) Andrew L. DeMond et al.   BIOPHYSICAL JOURNAL

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Organelle Transport: Dynamic Actin Tracks for Myosin Motors

(2008) Louise Cramer   CURRENT BIOLOGY

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY

MTOC translocation modulates IS formation and controls sustained T cell signaling

(2008) Noa B. Martín-Cófreces et al.   JOURNAL OF CELL BIOLOGY

Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration

(2008) Nicole A. Morin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY

Effects of Intracellular Calcium and Actin Cytoskeleton on TCR Mobility Measured by Fluorescence Recovery

(2008) Omer Dushek et al.   PLoS One

Implications of a poroelastic cytoplasm for the dynamics of animal cell shape

(2008) T.J. Mitchison et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity

(2008) Zhengyu Ma et al.   PLOS BIOLOGY