Journal
IMMUNOLOGICAL REVIEWS
Volume 247, Issue -, Pages 133-142Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-065X.2012.01117.x
Keywords
germinal centers; plasma cells; CD4+T-cell differentiation; IL-21; Maf; vaccines
Categories
Ask authors/readers for more resources
T-cell help to B cells is a fundamental aspect of adaptive immunity and the generation of B-cell memory (memory B cells and plasma cells). Follicular helper CD4+ T (Tfh) cells are the specialized providers of B-cell help, and Tfh cells depend on Bcl6 for their differentiation. This review discusses Tfh cell functions, transcription factors, and induction signals, with particular focus on the richness of the underlying biology and assessing the simplicity or complexity of each of these processes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
