The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists

(2012) P. D. Baum et al.   BLOOD

CD70-Driven Costimulation Induces Survival or Fas-Mediated Apoptosis of T Cells Depending on Antigenic Load

(2012) F. M. Wensveen et al.   JOURNAL OF IMMUNOLOGY

Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1

(2011) Felix M. Wensveen et al.   APOPTOSIS

Regulation of memory B-cell survival by the BH3-only protein Puma

(2011) C. Clybouw et al.   BLOOD

BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation

(2011) F. M. Wensveen et al.   BLOOD

Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes

(2011) E. B. M. Remmerswaal et al.   BLOOD

2-Deoxyglucose Induces Noxa-Dependent Apoptosis in Alveolar Rhabdomyosarcoma

(2011) S. Ramirez-Peinado et al.   CANCER RESEARCH

Akt-Dependent Glucose Metabolism Promotes Mcl-1 Synthesis to Maintain Cell Survival and Resistance to Bcl-2 Inhibition

(2011) J. L. Coloff et al.   CANCER RESEARCH

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

(2011) Andreas Strasser et al.   EMBO JOURNAL

The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants

(2011) Klaas P.J.M. van Gisbergen et al.   IMMUNITY

Noxa/Bcl-2 Protein Interactions Contribute to Bortezomib Resistance in Human Lymphoid Cells

(2011) Alyson J. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

(2011) Haiming Dai et al.   JOURNAL OF CELL BIOLOGY

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

(2011) Tanja A. Schwickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation

(2011) L. Janbazian et al.   JOURNAL OF IMMUNOLOGY

Opposing Effects of CD70 Costimulation during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection of Mice

(2011) P. Penaloza-MacMaster et al.   JOURNAL OF VIROLOGY

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells

(2011) Sonia Feau et al.   NATURE IMMUNOLOGY

Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes

(2011) A Dunkle et al.   Cell Death & Disease

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways

(2010) L Zhang et al.   CELL DEATH AND DIFFERENTIATION

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

(2010) Vandana Kalia et al.   IMMUNITY

Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones

(2010) Felix M. Wensveen et al.   IMMUNITY

Human T-cell memory consists mainly of unexpanded clones

(2010) Paul L. Klarenbeek et al.   IMMUNOLOGY LETTERS

Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses

(2010) J. P. Pereira et al.   INTERNATIONAL IMMUNOLOGY

Akt Requires Glucose Metabolism to Suppress Puma Expression and Prevent Apoptosis of Leukemic T Cells

(2010) Jonathan L. Coloff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anti-apoptotic Protein BCL2L1/Bcl-xL Is Neutralized by Pro-apoptotic PMAIP1/Noxa in Neuroblastoma, Thereby Determining Bortezomib Sensitivity Independent of Prosurvival MCL1 Expression

(2010) Judith Hagenbuchner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak

(2010) Han Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice

(2010) Shahram Salek-Ardakani et al.   JOURNAL OF CLINICAL INVESTIGATION

The Pim Kinase Pathway Contributes to Survival Signaling in Primed CD8+ T Cells upon CD27 Costimulation

(2010) V. Peperzak et al.   JOURNAL OF IMMUNOLOGY

Diversity of the CD8+ T Cell Repertoire Elicited against an Immunodominant Epitope Does Not Depend on the Context of Infection

(2010) B. D. Rudd et al.   JOURNAL OF IMMUNOLOGY

CD8 T Cell Cross-Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections

(2010) M. Cornberg et al.   JOURNAL OF IMMUNOLOGY

The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose

(2010) Xazmin H. Lowman et al.   MOLECULAR CELL

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

(2010) Kim L Good-Jacobson et al.   NATURE IMMUNOLOGY

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

(2010) E. M. Carrington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor   subunit CD25

(2010) S. Letourneau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory

(2010) I. Vikstrom et al.   SCIENCE

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

(2009) Lakshmi Srinivasan et al.   CELL

Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology

(2009) Martijn A. Nolte et al.   IMMUNOLOGICAL REVIEWS

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

(2009) Delphine Mérino et al.   JOURNAL OF CELL BIOLOGY

CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production

(2009) Victor Peperzak et al.   JOURNAL OF CLINICAL INVESTIGATION

Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells

(2009) S. M. Anderson et al.   JOURNAL OF IMMUNOLOGY

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation

(2009) L A Pradelli et al.   ONCOGENE

Secondary Replicative Function of CD8+ T Cells That Had Developed an Effector Phenotype

(2009) O. Bannard et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Surviving the crash: Transitioning from effector to memory CD8+ T cell

(2009) Louise M. D’Cruz et al.   SEMINARS IN IMMUNOLOGY

NF- B1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

(2008) A. Banerjee et al.   BLOOD

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

(2008) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity

(2008) Peter D. Hughes et al.   IMMUNITY

Apoptosis Regulators Bim and Fas Function Concurrently to Control Autoimmunity and CD8+ T Cell Contraction

(2008) Ashley E. Weant et al.   IMMUNITY

Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity

(2008) Jack Hutcheson et al.   IMMUNITY

Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre

(2008) David M Tarlinton   IMMUNOLOGY AND CELL BIOLOGY

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

(2008) Nancie J. MacIver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

APRIL affects antibody responses and early leukocyte infiltration, but not influenza A viral control

(2008) Gijs Hardenberg et al.   MOLECULAR IMMUNOLOGY

BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection

(2008) S. F. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells

(2008) Hendrik Streeck et al.   PLOS MEDICINE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY