Journal
IMMUNOLOGICAL REVIEWS
Volume 234, Issue -, Pages 305-316Publisher
WILEY
DOI: 10.1111/j.0105-2896.2009.00880.x
Keywords
dendritic cell; regulatory T cell; Foxp3+; microbe; commensal
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Funding
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI001115, ZIAAI001133] Funding Source: NIH RePORTER
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Each microenvironment is controlled by a specific set of regulatory elements that have to be finely and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes. Various populations of dendritic cells are central to the orchestration of this control. In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes.
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