Article
Immunology
Daisuke Chujo, Akitsu Kawabe, Maya Matsushita, Chiharu Tsutsumi, Fumitaka Haseda, Akihisa Imagawa, Toshiaki Hanafusa, Kohjiro Ueki, Hiroshi Kajio, Kunimasa Yagi, Kazuyuki Tobe, Masayuki Shimoda
Summary: The study revealed significantly upregulated IGRP and ZnT8-specific CD8+ T cell responses in FT1D and AT1D patients, with higher frequencies of IGRP-specific Tc1 cells in the FT1D group. These findings suggest a significant role of IGRP-specific CD8+ T cells in the pathogenesis of FT1D.
CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Review
Medicine, Research & Experimental
Tapan Behl, Amit Gupta, Aayush Sehgal, Ali Albarrati, Mohammed Albratty, Abdulkarim M. Meraya, Asim Najmi, Saurabh Bhatia, Simona Bungau
Summary: Type 2 diabetes is a widely spread metabolic disorder with limitations in conventional therapies. Protein tyrosine phosphatase is a promising therapeutic target, and various inhibitors have shown effectiveness in managing diabetes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Endocrinology & Metabolism
Yanping Han, Yuqing Chen, Chenyu Sun, Zhen Zhou
Summary: Compared with the pre-lockdown period, there was a significant improvement in the glycemic control of pediatric patients with type 1 diabetes (T1D) during and after the COVID lockdown. However, there was no significant change in HbA1c.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jinmin Miao, Jiajun Dong, Yiming Miao, Yunpeng Bai, Zihan Qu, Brenson A. Jassim, Bo Huang, Quyen Nguyen, Yuan Ma, Allison A. Murray, Jinyue Li, Philip S. Low, Zhong-Yin Zhang
Summary: In this study, researchers discovered the first highly potent and selective TC-PTP degrader called TP1L, which can induce degradation of TC-PTP and enhance T-cell signaling and tumor killing efficacy.
Article
Biochemistry & Molecular Biology
Sarah M. M. AL-Qabbaa, Samaher I. I. Qaboli, Tahani K. K. Alshammari, Maha A. A. Alamin, Haya M. M. Alrajeh, Lama A. A. Almuthnabi, Rana R. R. Alotaibi, Asma S. S. Alonazi, Anfal F. F. Bin Dayel, Nawal M. M. Alrasheed, Nouf M. M. Alrasheed
Summary: This study examined the therapeutic effects of sitagliptin, a dipeptidyl peptidase inhibitor, on diabetic nephropathy (DN). The results showed that sitagliptin can reduce inflammation and improve DN by inhibiting PTP1B and modulating the JAK/STAT signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Shefaly Shorey, Esperanza D. Ng, Evelyn C. Law, John C. M. Wong, Kah Yin Loke, Wilson W. S. Tam
Summary: This study assessed the effects of physical activity and nutrition-based interventions on children with type 1 diabetes. The findings showed that physical activity and nutrition-based interventions did not have a significant impact on glycemic control. However, the results highlighted the potential of these interventions in improving glycemic control and health-related quality of life.
Article
Biochemistry & Molecular Biology
James Adams, Benjamin P. Thornton, Lydia Tabernero
Summary: The study identified unique ligand cluster distributions specific to kinase interaction motif protein tyrosine phosphatases (KIM-PTPs) and found that ligand clusters coincide with functional and substrate binding sites in these PTPs. Ligand efficiency index (LEI) analysis showed that binders in these clusters reside in a more drug-like chemical-biological space. Differences in clusters across all KIM-PTPs highlight a distinct and specific profile for each phosphatase, with potential for exploiting unexplored allosteric functional sites for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Antonio Casamayor, Diego Velazquez, Carlos Santolaria, Marcel Albacar, Morten I. Rasmussen, Peter Hojrup, Joaquin Arino
Summary: Type 1 Ser/Thr protein phosphatases, represented by PP1 and PPZ, have distinct functions and regulations in fungi. PP1c enzymes are more conserved than PPZs. Specific residues in the catalytic domains of PP1 and PPZ have been identified, some of which likely affect the protein's surface charges. Hal3 is a specific inhibitor of PPZ phosphatases in many fungi, but the basis for their interaction is still unclear. The D566 and D615 residues in ScPpz1 may play a crucial role in the regulation of both enzymes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Milad Nazarzadeh, Zeinab Bidel, Dexter Canoy, Emma Copland, Malgorzata Wamil, Jeannette Majert, Karl Smith Byrne, Johan Sundstrom, Koon Teo, Barry R. Davis, John Chalmers, Carl J. Pepine, Abbas Dehghan, Derrick A. Bennett, George Davey Smith, Kazem Rahimi
Summary: Lowering blood pressure is an effective strategy for preventing new-onset type 2 diabetes. Different classes of antihypertensive drugs have varying effects on diabetes, with ACE inhibitors and ARBs showing the most favorable outcomes. Selective use of antihypertensive drugs can help prevent diabetes.
Article
Endocrinology & Metabolism
Phoebe Loxton, Kruthika Narayan, Craig F. Munns, Maria E. Craig
Summary: This study found abnormal bone development and reduced bone mineral density in youth with type 1 diabetes through systematic review and meta-analysis using multiple modalities. Routine assessment of bone mineral density should be considered for all youth with type 1 diabetes.
Article
Biochemistry & Molecular Biology
Meng Chen, Yuan Dong, Lijie Tian, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: MTSS1 promotes adipocyte differentiation by interacting with PTPRD to activate SFKs, such as FYN tyrosine kinase.
Article
Oncology
Alexander Drilon, Manish R. Sharma, Melissa L. Johnson, Timothy A. Yap, Shirish Gadgeel, Dale Nepert, Gang Feng, Micaela B. Reddy, Allison S. Harney, Mohamed Elsayed, Adam W. Cook, Christina E. Wong, Ronald J. Hinklin, Yutong Jiang, Eric N. Brown, Nickolas A. Neitzel, Ellen R. Laird, Wen - Wu, Anurag Singh, Ping Wei, Keith A. Ching, John J. Gaudino, Patrice A. Lee, Dylan P. Hartley, S. Michael Rothenberg
Summary: PF-07284892, an allosteric SHP2 inhibitor, combined with various oncogenic driver inhibitors, overcame bypass-signaling-mediated resistance in clinical settings. This combination therapy showed significant tumor and circulating tumor DNA responses, extending the duration of overall clinical benefit in patients with targeted therapy resistance in lung, colorectal, ovarian, and pancreatic cancer.
Article
Chemistry, Medicinal
Rosanna Maccari, Gerhard Wolber, Massimo Genovese, Gemma Sardelli, Valerij Talagayev, Francesco Balestri, Simone Luti, Alice Santi, Roberta Moschini, Antonella Del Corso, Paolo Paoli, Rosaria Ottana
Summary: Type 2 diabetes mellitus (T2DM) is a serious chronic disease with a growing prevalence worldwide. Current treatment relies on drug combinations, but recently there has been interest in developing multiple-targeted drugs for complex diseases like T2DM. In this study, the researchers designed new compounds that inhibit both PTP1B and AKR1B1, two enzymes crucially involved in the development of T2DM and its complications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Cell Biology
Francisca Cornejo, Bastian I. Cortes, Greg M. Findlay, Gonzalo I. Cancino
Summary: Protein phosphatases are key regulators of signal transduction, with the LAR-RPTP subfamily playing an important role in neurobiology, from neurodevelopment to brain disorders. The LAR-RPTP subfamily consists of three members in vertebrates and is involved in various brain functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Rheumatology
Yan-Mei Mao, Tao Liao, Qian-Ling Ye, Guo-Cui Wu, Qin Zhang, Sha-Sha Tao, Chan-Na Zhao, Qian Wu, Yi-Lin Dan, Hai-Feng Pan, Dong-Qing Ye
Summary: This study evaluated the circulating level of sclerostin in rheumatoid arthritis (RA) patients and summarized its role. The meta-analysis showed that RA patients had higher circulating sclerostin levels compared to normal controls. Subgroup analyses indicated that age, region, and assay method were associated with sclerostin level in RA patients.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Environmental Sciences
Bo Liu, Xin-Yu Fang, Yu-Lu Yan, Jun Wu, Xiao-Jie Lv, Jie Zhang, Liang-Wei Qi, Ting-Ting Qian, Yu-Yu Cai, Yin-Guang Fan, Dong-Qing Ye
Summary: There is an association between ambient temperature and outpatient visits for warts, where both low and high temperatures increase the risk while a large temperature drop is protective. Males and younger individuals are more sensitive to temperature, while the elderly are more susceptible to temperature changes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
J. Ni, L-J Qiu, K-J Yin, G-M Chen, H-F Pan
Summary: This study found moderate genetic correlations between T2D and COVID-19 severity, but MR analysis did not support a causal effect of T2D on severe COVID-19. Genes with significant associations with both T2D and COVID-19 severe were enriched for biological pathways related to the response to type I interferon, glutathione derivative metabolism, and glutathione derivative biosynthesis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Immunology
Fan Cao, Yi-Sheng He, Yan Wang, Chen -Kai Zha, Jia-Min Lu, Li-Ming Tao, Zheng-Xuan Jiang, Hai-Feng Pan
Summary: This study aims to describe the burden of autoimmune diseases (ADs) including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), and psoriasis (PS), and explore the inequalities across countries with different sociodemographic development levels. Results show significant variations in the age-standardized DALYs rate and age and sex distribution of DALYs rate for the four ADs across 204 countries. The study utilizes slope index of inequality and concentration index to quantify the distributive inequalities in the burden of ADs.
AUTOIMMUNITY REVIEWS
(2023)
Article
Environmental Sciences
Jie Zhang, Xin-Yu Fang, Jun Wu, Yin-Guang Fan, Rui-Xue Leng, Bo Liu, Xiao-Jie Lv, Yu-Lu Yan, Chen Mao, Dong-Qing Ye
Summary: This study investigated the associations between various air pollutants and the risk of incident rheumatoid arthritis (RA) and further estimated the impact of combined exposure to ambient air pollutants on the risk of developing RA under the modification effect of genetic predisposition.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Review
Surgery
Yu-Chen Liu, Chuan-Lu Shen, Zi-Yue Fu, Yu-Chen Zhang, Yan-Xun Han, Bang-Jie Chen, Yuan Jiang, Si-Yue Yin, Zhi Tao, Shu-Yan Sheng, Jian-Peng Wang, Bing-Yu Liang, Liang Zhang, Dong Wang, Kai-Le Wu, Hai-Feng Pan, Ye-Hai Liu
Summary: The effectiveness of intraoperative nerve monitoring (IONM) in endoscopic thyroid surgery was explored in this study. The results showed that IONM significantly reduced the incidence of transient recurrent laryngeal nerve (RLN) palsy, but did not significantly reduce the incidence of permanent RLN palsy. However, there was a significant reduction in total RLN palsy. Additionally, IONM effectively reduced the localization time of the RLN and increased the identification rate of the superior laryngeal nerve. Therefore, the use of IONM is recommended for malignant tumors.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Environmental Sciences
Fan Cao, Zhuo-Ran Liu, Qin-Yu Ni, Chen-Kai Zha, Shu-Jie Zhang, Jia-Min Lu, Yue-Yang Xu, Li-Ming Tao, Zheng-Xuan Jiang, Hai-FenG Pan
Summary: Autoimmune eye diseases (AEDs) are a group of autoimmune inflammatory ocular conditions caused by immune system dysregulation at the ocular level, which can affect both intraocular and periorbital structures, leading to severe visual deficit and global blindness. The roles of air pollution and meteorological factors in the initiation and progression of AEDs have become increasingly attractive, with both systemic and local mechanisms involved. Exposure to excessive air pollution and extreme meteorological conditions can disturb the Th17/Treg balance, regulate macrophage polarization, activate neutrophils, induce systemic inflammation and oxidative stress, decrease retinal blood flow, promote tissue fibrosis, activate the sympathetic nervous system, adversely affect nutrient synthesis, and induce heat stress, which together may worsen AEDs. The interplay among inflammation, oxidative stress, and dysregulated immune system appears to be prominent. This review focuses on the potential mechanisms underlying the connections between air pollution and meteorological factors and ocular autoimmune and inflammatory responses. Furthermore, we concentrate on the specific roles of air pollutants and meteorological factors in several major AEDs including uveitis, Graves' ophthalmopathy (GO), ocular allergic disease (OAD), glaucoma, diabetic retinopathy (DR), etc.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biophysics
Guixia Pan, Jian Cheng, Hai-Feng Pan, Yin-Guang Fan, Dong-Qing Ye
Summary: This study aimed to assess the disease burden of chronic obstructive pulmonary disease (COPD) attributable to air pollution from multiple epidemiological perspectives. The results showed that in 2019, COPD deaths associated with air pollution accounted for 2.32% of global total deaths, and the disease-adjusted life years (DALY) accounted for 1.12% of global DALY. The number of COPD deaths associated with air pollution increased from 1990 to 2019, peaking at 1.41 million in 1993, and then declined. The burden of COPD associated with air pollution was also influenced by national indicators. Therefore, health policymakers are called to take action and interventions targeting vulnerable countries and populations.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Article
Environmental Sciences
Wuli Li, Xirun Zong, Yi-Sheng He, Xinpai Liu, Chunhui Zhao, Yuanyin Wang, Jing Zhang, Hai-Feng Pan
Summary: This study aimed to determine the impact of air pollution on the risk of periodontitis outpatient visits. A total of 56,456 periodontitis outpatient visits in Hefei, China, from January 1, 2014, to December 31, 2021, were analyzed. The findings suggest that NO2 exposure is associated with an increased risk of periodontitis outpatient visits, while O3 exposure is associated with a decreased risk. Season was found to modify these associations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Immunology
Yuchen Liu, Zhechen Wu, Ziyue Fu, Yanxun Han, Jianpeng Wang, Yanqiang Zhang, Bingyu Liang, Ye Tao, Yuchen Zhang, Chuanlu Shen, Yidan Xu, Siyue Yin, Bangjie Chen, Yehai Liu, Haifeng Pan, Zhang Liang, Kaile Wu
Summary: This study investigated focal adhesion-related genes (FARGs) in head and neck squamous cell carcinoma (HNSCC) and identified two molecular subtypes. A FARG signature model consisting of 9 genes was developed and proven to be a reliable prognostic predictor for HNSCC patients. Furthermore, FARGs were found to be associated with immune infiltration, gene mutation status, and chemosensitivity, providing potential targets for targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xi Fang, Cong Chen, Zhi-Xin Wang, Yan Zhao, Ling-Qiong Jiang, Yang Fang, Ruo-Di Zhang, Hai-Feng Pan, Sha-Sha Tao
Summary: The purpose of this study was to evaluate the serum Dickkopf-1 (DKK-1) level in ankylosing spondylitis (AS) patients compared to normal controls and to test the causal relationship between DKK-1 and AS risk. The meta-analysis of 40 studies showed no significant difference in DKK-1 serum level between AS patients and normal controls. The MR analysis also demonstrated no significant association between DKK-1 serum level and AS risk.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Cong Chen, Yi-Sheng He, Sha-Sha Tao, Yang Fang, Ruo-Di Zhang, Xi Fang, Ling-Qiong Jiang, Yan Zhao, Harry Asena Musonye, Jin-Hui Tao, Hai-Feng Pan
Summary: This study aimed to investigate the short-term correlation between meteorological factors and dermatomyositis (DM) outpatient visits. The findings showed significant associations between low temperature, humidity, diurnal temperature range, and temperature change and the risk of DM outpatient visits. Furthermore, women were more susceptible to high humidity and low temperature change, while the elderly were more susceptible to low temperature. In conclusion, exposure to low temperature, extreme humidity, and temperature changes (especially high diurnal temperature range and low temperature change) were associated with an increased risk of DM outpatient visits.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Yongrui Chen, Huiying Li, Guilin Qi, Tianxing Wu, Tenggou Wang
Summary: Query graph construction aims to generate a correct SPARQL query to answer natural language questions on a knowledge graph. Existing methods face challenges in handling complex questions including complicated SPARQL syntax, huge search space, and locally ambiguous query graphs. This paper proposes a novel end-to-end approach that leverages a unified graph grammar called AQG and hierarchical autoregressive decoding to construct query graphs effectively. Experimental results demonstrate that the proposed method significantly improves the state-of-the-art performance on complex KGQA benchmarks.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Environmental Sciences
Wuli Li, Xirun Zong, Yi-Sheng He, Tiantian Meng, Ying Tang, Qi Yang, Qing Huang, Yuanyin Wang, Song Li, Hai-Feng Pan
Summary: Evidence suggests a possible association between ambient air pollutants and oral diseases. The present study aimed to investigate the relationship between short-term exposure to air pollution and outpatient visits for pulpitis. The results showed that exposure to NO2, PM2.5, and CO were positively correlated with an increased risk of pulpitis outpatient visits, while exposure to O-3 was associated with a decreased risk. Age and season were found to be effect modifiers of these associations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
