Journal
IMMUNOLOGICAL INVESTIGATIONS
Volume 41, Issue 3, Pages 249-260Publisher
INFORMA HEALTHCARE
DOI: 10.3109/08820139.2011.622828
Keywords
Tolerogenic DNA vaccine; prevention; autoimmune disease
Categories
Funding
- National Natural Science Foundation of China [31070805]
- Key Laboratory for Agro-Microbial Resource and Application, Ministry of Agriculture [201003]
- Chinese Universities Scientific Fund
- State Key Laboratory of Agro-Biotechnology [2009SKLAB08-2]
- State Experiment Innovation for Undergraduates [091001913]
- National High Technology Development Program
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DNA vaccines have been widely used to induce immune responses against molecular targets. In this study, we explored the possibility of using DNA vaccine combined with the immunosuppressant FK506 (tacrolimus) to antigen-specifically suppress unwanted immune responses and prevent autoimmune ovarian disease. To that end, we immunized C57BL/6 mice with a DNA vaccine encoding mouse zona pellucida 3 (ZP3) together with FK506. The immunization induced ZP3-specific CD4(+)CD25(+)Foxp(3+) regulatory T cells (Treg), which suppressed the induction of ZP3-specific delayed-type hypersensitivity in the animals. Significantly, the immunization also protected the animals from experimentally induced autoimmune ovarian disease. These results suggest that DNA vaccination in the presence of FK506 may be used to induce Treg cells and prevent AOD.
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