Article
Immunology
Adil Ahmed Ali, Khalid Eltahir Khalid, Somaya Elhaj Mohammed, Mohammed Salman Akhtar, Osman Khalafalla Saeed
Summary: The aim of this study was to determine the frequency of HLA class II alleles and haplotypes in Sudanese patients with Rheumatoid Arthritis (RA). The study found that HLA-DRB1*04 and *10 alleles were more common in RA patients, while HLA-DRB1*07 allele was significantly less common. HLA-DQB1*03 allele was strongly associated with RA risk, whereas HLA-DQB1*02 and *06 showed protective effects against RA. Several specific HLA haplotypes were also found to be significantly associated with RA risk or protection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Navia Vinoy, Neethu Sheeja, Suresh Kumar, Lalitha Biswas
Summary: The study identified HLA-DRB1 * 15:01, 15:02, and DQB1 * 06:02 as predisposing alleles for MS in our population, while HLA-DRB1 * 14:04 was found to be a protective allele. Significant associations were also observed between HLA-DRB1 alleles and IL7R (rs6897932) genotypes in MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Multidisciplinary Sciences
Leidy Pedraza, Milena Camargo, Darwin A. Moreno-Perez, Ricardo Sanchez, Luisa Del Rio-Ospina, Indira M. Baez-Murcia, Manuel E. Patarroyo, Manuel A. Patarroyo
Summary: This study identified 16 HLA-DRB1 alleles in Colombian women that significantly influence the outcome of Chlamydia trachomatis infection. DRB1*08:02:01G and DRB1*12:01:01G were related to infection-promoting events, while only the DQB1*05:03:01G allele related to clearance/persistence events. Women homozygous for HLA-DRB1 alleles were associated with lower clearance probability and/or early occurrence of persistence.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Paulin Sonon, Maria Lucia Brito Ferreira, Renata Santos Almeida, Neifi Hassan Saloum Deghaide, Glauco Henrique Willcox, Elizabeth Lima Guimaraes, Antonio Fernando da Purificacao Junior, Marli Tenorio Cordeiro, Carlos Alexandre Antunes de Brito, Maria de Fatima Militao de Albuquerque, Roberto D. Lins, Eduardo A. Donadi, Norma Lucena-Silva
Summary: The study found that specific HLA-DRB1/DQA1/DQB1 genotypes/haplotypes were overrepresented in patients exhibiting neurological complications during the Brazilian 2015-2016 arbovirus outbreak. Certain allele groups were also identified to have a protective effect against arbovirus neurological manifestation, being underrepresented in both the whole group of patients and in patients with peripheral neurological spectrum disorders (PSD) or encephalitis spectrum disorders (ESD).
JOURNAL OF INFECTIOUS DISEASES
(2021)
Editorial Material
Cell Biology
Maria Loginova, Daria Smirnova, Svetlana Kutyavina, Igor Paramonov
Summary: The two novel HLA alleles, DRB1*12:90 and DQB1*03:458, have non-synonymous mutations in exon 3.
Article
Medical Laboratory Technology
Ji Won In, Kiwook Jung, Sue Shin, Kyoung Un Park, Hajeong Lee, Eun Young Song
Summary: This study investigated the association of HLA-DRB1 and -DQB1 alleles with the susceptibility to IgA nephropathy (IgAN) and its progression to end-stage kidney disease (ESKD) in Korean patients. The findings revealed novel associations between certain HLA alleles and IgAN, as well as a significant difference in the frequency of an HLA allele between ESKD and non-ESKD groups.
ANNALS OF LABORATORY MEDICINE
(2022)
Editorial Material
Cell Biology
Ahmad Abu-Khader, Alison J. Gareau, Caitlyn Burns, Faisal Khan, Noureddine Berka
Summary: This study identified two novel HLA class II alleles, HLA-DRB1*01:115 and HLA-DRB1*14:224, using NGS technology.
Article
Neurosciences
Sasiharan Pandi, Rathika Chinniah, Vandit Sevak, Padma Malini Ravi, Muthuppandi Raju, Neethi Arasu Vellaiappan, Balakrishnan Karuppiah
Summary: The study identified specific HLA alleles that may be associated with susceptibility and protection against Parkinson's disease.
NEUROSCIENCE LETTERS
(2021)
Article
Immunology
David G. Hernandez-Mejia, Ivan Aurelio Paez-Gutierrez, Valerie Dorsant Ardon, Nathalie Camacho Ramirez, Melissa Mosquera, Paola Andrea Cendales, Bernardo Armando Camacho
Summary: The main limitation in finding compatible donors is the HLA compatibility, especially if no identical match is found within the patient's family group. Bone marrow registries have allowed the identification of 10/10 compatible unrelated donors, but the availability and frequency of haplotypes and HLA alleles vary among ethnic groups and geographical areas, making it difficult to find identical matches in international registries.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sigrid Le Clerc, Laura Lombardi, Bernhard T. Baune, Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott R. Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Rafaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hofmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John R. Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, SusanG Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Urban Osby, Andrea Pfennig, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofeld, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Claudia Pisanu, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Wahid Boukouaci, Jean-Romain Richard, Philippe Le Corvoisier, Caroline Barrau, Jean-Francois Zagury, Marion Leboyer, Ryad Tamouza
Summary: The study revealed that certain amino acid variants within the HLA-DRB1*11:01 classical allele are associated with different responses to lithium treatment in bipolar affective disorder patients. This suggests that the inflammatory background mediated by HLA genes may impact the efficacy of lithium treatment in BD.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Maria Loginova, Svetlana Druzhinina, Igor Paramonov
Summary: Three novel HLA-DRB1 alleles, HLA-DRB1*07:150, HLA-DRB1*13:345 and HLA-DRB1*14:256, were identified.
Article
Biochemistry & Molecular Biology
Sidnooma Veronique Zongo, Florencia Wendkuuni Djigma, Albert Theophane Yonli, Pegdwende Abel Sorgho, Bolni Marius Nagalo, Lassina Traore, Dogfounianalo Somda, Lanyo Jospin Amegnona, Eugene Languie, Couna Christiane Bere Some, Lydie Marie Jeannette Sia, Issa Boaffi Sourabie, Roger Arsene Sombie, Abdel Karim Serme, Dorcas Obiri-Yeboah, Jacques Simpore
Summary: This study found that the HLA-DRB1*12 allele in the Human Leucocyte Antigen (HLA) system may have a protective effect in HBV infection, while HLA-DRB1*11 increases the risk of developing severe liver disease.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Immunology
Xin Wan, Ying Wang, Peipei Jin, Ju Zhang, Liu Liu, Zhangfei Wang, Yue Hu
Summary: This study investigated the presence and influence of HLA class II alleles on disease risk and autoantibody status in Chinese Han patients with RA, showing strong positive associations between specific HLA alleles and RA. Certain HLA haplotypes were found to be more frequent in RA patients compared to healthy controls, indicating their potential role as risk alleles. Serological results suggested that carrying RA-risk HLA alleles may affect the serum levels of anti-citrullinated protein antibodies and rheumatoid factor, influencing RA progression.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Editorial Material
Cell Biology
Anastasiia Ananeva, Nailia Osipova, Alina Shaihutdinova, Anna Andryushkina, Elena Shagimardanova
Summary: Three new DQB1 alleles, DQB1*03:02:33, DQB1*04:79, and DQB1*05:249, were identified in Russian individuals through next-generation sequencing.
Editorial Material
Cell Biology
Magali Devriese, Sephora Da Silva, Maryvonnick Carmagnat, Jean-Luc Taupin
Summary: HLA-DRB1*07:143N and HLA-DRB1*07:144 differ from DRB1*07:01:01:01 by single mismatches in exons 3 and 2 respectively.
Article
Immunology
Ayman Hammad, Youssef M. Mosaad, Enas M. Hammad, Samir Elhanbly, Sherif R. El-Bassiony, Mohammad F. Al-Harrass, Riham Eid, Omar A. Sharaf Eldein, Gehan Attia Alsawah, Sohier Yahia, Iman M. Fawzy
Article
Immunology
Y. M. Mosaad, A. Hammad, Z. Fawzy, A. El-Refaaey, Z. Tawhid, E. M. Hammad, L. F. Youssef, E. A. A. ElAttar, D. F. Radwan, I. M. Fawzy
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2015)
Article
Immunology
Ashraf A. Elghzaly, Shereen S. Metwally, Farha A. El-Chennawi, Maha A. Elgayaar, Youssef M. Mosaad, Ehab E. El-Toraby, Mohsen M. Hegab, Saleh M. Ibrahim
Article
Oncology
Youssef M. Mosaad, Rasha Elashery, Ahmad Darwish, Omar A. Sharaf Eldein, Tarek Barakat, Samy Marouf, Noha T. Abou El-Khier, Laila F. Youssef, Iman M. Fawzy
LEUKEMIA & LYMPHOMA
(2017)
Article
Rheumatology
A. Hammad, E. Osman, Y. Mosaad, M. Wahba
Article
Rheumatology
A. Hammad, Y. M. Mossad, N. Nasef, R. Eid
Article
Immunology
Youssef M. Mosaad, Ehab E. S. El-Toraby, Ziyad M. E. Tawhid, Adel I. Abdelsalam, Asmaa F. Enin, Amany M. E. Hasson, Ghada M. Shafeek
IMMUNOLOGICAL INVESTIGATIONS
(2018)
Article
Immunology
Youssef M. Mosaad, Shereen S. Metwally, Raghda E. Farag, Zakeria F. Lotfy, Hosam E. AbdelTwab
IMMUNOLOGICAL INVESTIGATIONS
(2019)
Article
Rheumatology
Y. M. Mosaad, A. Hammad, A. A. Elghzaly, Z. M. E. Tawhid, E. M. Hammad, A. Showma, R. Abdelsalam, A. Elmoughy, I. M. Fawzy, N. Anber
Article
Oncology
Youssef M. Mosaad, Mohamed Khashaba, Ahmad Darwish, Mohamed Darwish, Mona Elwassefy, Souzy Abdelmabood, Iman M. Fawzy, Laila F. Youssef, Rehab A. Elbasiouny
PEDIATRIC HEMATOLOGY AND ONCOLOGY
(2019)
Article
Behavioral Sciences
Noura El Adle Khalaf, Farida Mohamed El Banna, Mona Younis Youssef, Youssef Mohammed Mosaad, Mohamed-Hesham Yousry Daba, Rehab Hamdy Ashour
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2020)
Article
Oncology
Youssef M. Mosaad, Magdy A. El-Ziny, Ahmad Darwish, Mohammad Al-Harrass, Suzy Abdmabood, Iman M. Fawzy, Doa M. Sherif, Mostafa G. Yakoub, Hosam Abdeltawab
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2020)
Article
Rheumatology
Youssef M. Mosaad, Ayman Hammad, Mohamed F. AlHarrass, Rehab Sallam, Amany Shouma, Enas Hammad, Engy Osman Ahmed, Heba A. Abdel-Azeem, Doaa Sherif, Iman Fawzy, Amany Elbahnasawy, Hosam Abdel Twab
Summary: The study investigated the association between ARID5B gene polymorphisms and SLE, especially LN, in Egyptian children, revealing that ARID5B rs10821936 may be a susceptibility risk factor for juvenile SLE. However, rs10994982 was not found to be associated with jSLE.
Article
Parasitology
Aliaa M. Elsawey, Suzan H. Elgendy, Salam A. A. Abdel-Magied, Yousef Mosaad, Nairmen Nabih
PARASITOLOGISTS UNITED JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Sherif Arafa, Sherehan Abdelsalam, Abdel-Hady El-Gilany, Youssef Mohamed Mosaad, Adel Abdel-Ghaffar
EGYPTIAN HEART JOURNAL
(2018)