Article
Medicine, General & Internal
Yin Ping Wong, Noorhafizah Wagiman, Jonathan Wei De Tan, Barizah Syahirah Hanim, Muhammad Syamil Hilman Rashidan, Kai Mun Fong, Naufal Naqib Norhazli, Yashini Qrisha, Raja Norazah Raja Alam Shah, Muaatamarulain Mustangin, Haliza Zakaria, Siew Xian Chin, Geok Chin Tan
Summary: This study aimed to investigate the immunoexpression of CXC-chemokine receptor 1 (CXCR1) in placentas with chorioamnionitis and its association with adverse perinatal outcomes. The study found that the loss of CXCR1 expression in umbilical cord endothelial cells was significantly associated with an increased risk of adverse perinatal outcomes, such as fetal death.
Review
Physiology
Andrew Parsons, Adom Netsanet, Gregory Seedorf, Steven H. Abman, Elizabeth S. Taglauer
Summary: This review discusses the role of the placenta in predisposing to bronchopulmonary dysplasia (BPD) and proposes a unique placental-pulmonary connection. The authors explore this hypothesis through analysis of literature and preclinical models, and discuss the impact of antenatal steroids on fetal lung development.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Shuhan Jiang, Wei Zhang, Qing Cao, Maryam Rahbar, William Cooke, Masayuki Ono, Kenichi Fujimaki, Atsushi Saito, Makoto Itonaga, Kenta Oda, Christopher Redman, Manu Vatish
Summary: The ExoCounter assay developed in this study can detect small placental extracellular vesicles in the plasma of pregnant women at high risk of developing preeclampsia, providing an opportunity for early intervention.
Article
Biochemistry & Molecular Biology
Heyam Hayder, Guodong Fu, Lubna Nadeem, Jacob A. O'Brien, Stephen J. Lye, Chun Peng
Summary: The overexpression of miR-210-3p reduces trophoblast migration and invasion, affects EVT outgrowth in early pregnancy explants, and decreases the ability of trophoblast to form endothelial-like networks. Furthermore, miR-210-3p downregulates the expression of certain cytokines, potentially influencing EVT invasion and immune cell recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marta Magatti, Alice Masserdotti, Anna Cargnoni, Andrea Papait, Francesca Romana Stefani, Antonietta Rosa Silini, Ornella Parolini
Summary: The pathophysiology of preeclampsia involves immune cells, with B cells playing a significant role in its development. Perinatal cells, derived from birth-associated tissues, have immunomodulatory properties that could potentially be used to regulate B cell activation and function, representing a novel therapeutic strategy for preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Morgan R. Firestein, Harvey J. Kliman, Ayesha Sania, Lucy T. Brink, Parker H. Holzer, Katherine M. Hofmann, Kristin M. Milano, Nicolo Pini, Lauren C. Shuffrey, Hein J. Odendaal, William P. Fifer
Summary: Objective trophoblast inclusions are associated with adverse birth outcomes and specific placental pathologies. The presence of trophoblast inclusions is significantly higher in preterm and stillborn deliveries compared to full-term liveborn deliveries. These findings suggest the need for further investigation into the complex mechanisms underlying trophoblast inclusions.
Article
Developmental Biology
Magdi M. Salih, Lobna E. Ali, Emad M. Eed, Ahmed Abu Siniyeh
Summary: The study found significant structural differences in the chorion and chorionic villi vessels of patients with preeclampsia compared to normotensive women, without significant differences in lumen area. Future research should focus on morphological events throughout pregnancy, including associations between arterial elastic properties and structural proteins in hypertensive patients.
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Article
Medicine, General & Internal
Yin Ping Wong, T. Yee Khong
Summary: Neonates born with the fetal inflammatory response (FIR) are at risk of complications such as early-onset neonatal sepsis, meningitis, and pneumonia. This study evaluated the diagnostic performance of umbilical cord (UC) section in identifying FIR and investigated clinical predictors of umbilical cord FIR. The results showed that UC section diagnosis of FIR is reasonably accurate in cases with clinical chorioamnionitis, fever, and/or prolonged rupture of membrane (PROM).
Review
Biochemistry & Molecular Biology
Mingyu Hu, Ji Li, Philip N. Baker, Chao Tong
Summary: Preeclampsia is a major threat to the health of mothers and newborns worldwide, primarily due to placental metabolic abnormalities leading to placental dysfunction.
Review
Environmental Sciences
Miaoliang Wu, Fuhui Yan, Qian Liu, Ganzhong Liao, Yilin Shen, Zhi Bai, Xiaoshan Liu
Summary: Preeclampsia (PE) is a disease that occurs after 20 weeks of pregnancy and is characterized by new onset hypertension and albuminuria or other end-organ damage. It is a major complication of pregnancy that can increase morbidity and mortality in pregnant women and fetuses, causing significant social burden. Recent research suggests that exposure to environmental xenobiotic compounds, particularly endocrine disruptors, may contribute to the development of PE. However, the specific mechanisms underlying this relationship remain unclear. This paper reviews the role and potential mechanism of PE induced by exogenous chemicals and provides an outlook on the environmental etiology of PE.
Article
Environmental Sciences
Elia Shazniza Shaaya, Siti Atiqah Abdul Halim, Ka Wen Leong, Kevin Boon Ping Ku, Pei Shan Lim, Geok Chin Tan, Yin Ping Wong
Summary: Candida chorioamnionitis presents characteristic gross and histological findings on the umbilical cord, often associated with gestational diabetes mellitus and high risk of adverse perinatal and neonatal outcomes. Careful examination of the umbilical cord is recommended in mothers with gestational diabetes mellitus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Cell Biology
Megan A. Opichka, Matthew W. Rappelt, David D. Gutterman, Justin L. Grobe, Jennifer J. McIntosh
Summary: Preeclampsia is a life-threatening cardiovascular disorder associated with pregnancy, potentially caused by dysfunction in maternal and placental blood vessels and other factors. Current gaps in knowledge include detailed understanding of its underlying causes and effective treatment options.
Article
Environmental Sciences
Habyeong Kang, Hee-Sun Kim, Yeong Sook Yoon, Jeongsun Lee, Younglim Kho, Jisun Lee, Hye Jin Chang, Yoon Hee Cho, Young Ah Kim
Summary: This study found that the transfer of PFASs through the placenta varies by compounds, with PFOA and PFHxS showing higher transfer rates compared to PFOS. Additionally, gestational age and birth weight were positively related to the placental transfer rate of PFASs, while pre-pregnancy BMI and weight were inversely related, highlighting the importance of pregnancy-related factors in the placental transfer of PFASs. Further research on novel PFASs in Korean pregnant women is recommended.
Article
Developmental Biology
Fatma Simsek, Ezgi Turunc, Elif Keskin-Arslan, Hilal Erol, Selin Acar, Bahar Konuralp Atakul, Serpil Aydogmus, Tijen Temiz
Summary: This study aimed to investigate the differences in endothelin-1 (ET-1) levels in placenta, umbilical cord, and maternal blood in patients with preeclampsia (PE) and to understand the changes in umbilical artery contraction response. The results showed higher levels of ET-1 expression and lower levels of miR-125b expression in the placenta of the PE group compared to the control group. Additionally, the PE group exhibited changes in the morphology of umbilical cord vessels. However, there were no significant differences in ET-1 responses between the groups in the tissue bath experiments.
Review
Immunology
Jaume Alijotas-Reig, Enrique Esteve-Valverde, Raquel Ferrer-Oliveras, Luis Saez-Comet, Elmina Lefkou, Arsene Mekinian, Cristina Belizna, Amelia Ruffatti, Angela Tincani, Luca Marozio, Gerard Espinosa, Ricard Cervera, Roberto Rios-Garces, Sara De Carolis, Omar Latino, Elisa LLurba, Cecilia Beatrice Chighizola, Maria Gerosa, Vittorio Pengo, Krista Lundelin, Patrizia Rovere-Querini, Valentina Canti, Karoline Mayer-Pickel, Tatiana Reshetnyak, Ariela Hoxha, Sara Tabacco, Ldjumila Stojanovich, Vassiliki Gogou, Aikaterini Varoudis, Anna Arnau, Domingo Ruiz-Hidalgo, Jaume Trape, Laia Sos, Carlotta Stoppani, Anna Marti-Canamares, Inmaculada Farran-Codina, Maria Tiziana Bertero, Anna Kuzenko, Emmanuel Coloma, Pier Luigi Meroni, Lucilda Stojanovich, Anna Ruano, Teresa del Ross, Tania Melnychuk, Valetina Canti, Vittorio Pengo, Beatrice Chighizola, Maria Gerosa, Micaela Fredi, Krista Lundelin, Elisa Picardo, Elisa Llurba, Ricard Cervera, Arsene Mekinian, Bettina Toth, Luis Saez-Comet, Katharina Bremme, Karoline Mayer-Pickel, Antonio Gil-Aguado, Laia Sos, Carlotta Stoppani, Ariela Hoxha, Inmaculada Farran-Codina
AUTOIMMUNITY REVIEWS
(2019)
Article
Obstetrics & Gynecology
Sara De Carolis, Sascia Moresi, Francesca Rizzo, Giuseppina Monteleone, Sara Tabacco, Silvia Salvi, Cristina Garufi, Antonio Lanzone
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2019)
Review
Medicine, Research & Experimental
Eric Barbarite, Sidharth V. Puram, Adeeb Derakhshan, Esther D. Rossi, William C. Faquin, Mark A. Varvares
Review
Oncology
Esther Diana Rossi, William C. Faquin, Liron Pantanowitz
CANCER CYTOPATHOLOGY
(2019)
Article
Oncology
Giuseppe Angelico, Angela Santoro, Frediano Inzani, Saveria Spadola, Vincenzo Fiorentino, Federica Cianfrini, Claudia Carbone, Giorgia Garganese, Esther D. Rossi, Giovanni Scambia, Gian F. Zannoni
CANCER CYTOPATHOLOGY
(2019)
Article
Pathology
Francesca Ambrosi, Esther Diana Rossi, Serena Calderoni, Maria Cristina Cucchi, Gianni Saguatti, Maria P. Foschini
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2020)
Editorial Material
Oncology
Esther Diana Rossi, Liron Pantanowitz
CANCER CYTOPATHOLOGY
(2019)
Article
Obstetrics & Gynecology
Maria Pia De Carolis, Giovanna Casella, Erika Serafino, Giovanni Pinna, Carmen Cocca, Sara De Carolis
Summary: The study demonstrated that positioning UVC in the delivery room can help ELBW neonates reach normal body temperature and blood glucose levels faster after birth, and reduce the incidence of hypothermia. This intervention is more common among newborns born during the morning shift.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Pediatrics
Alessandro Perri, Milena Tana, Riccardo Riccardi, Rossella Iannotta, Lucia Giordano, Serena Antonia Rubortone, Francesca Priolo, Domenico V. Di Molfetta, Enrico Zecca, Giovanni Vento
PEDIATRIC PULMONOLOGY
(2020)
Article
Pediatrics
Iliana Bersani, Sara De Carolis, Dirk Foell, Toni Weinhage, Cristina Garufi, Maria Pia De Carolis, Esther Diana Rossi, Giovanna Casella, Serena Antonia Rubortone, Christian Paul Speer
Summary: The study found that S100A12 could not accurately identify mothers with HCA or very preterm infants exposed to HCA. However, IL-6 and CRP levels were higher in maternal blood of the HCA group compared with controls. High concentrations of S100A12 were detected in cord and neonatal blood of some neonates exposed to HCA with advanced funisitis.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Oncology
Esther Diana Rossi, Liron Pantanowitz, Marco Raffaelli, Guido Fadda
Summary: The increasing use of ultrasound in diagnosing thyroid nodules has led to a rise in fine needle aspirations for evaluation. Different tools, such as clinical factors and reporting systems, are being used to stratify the risk of thyroid nodules accurately. Establishing high concordance between ultrasound features and cytologic diagnoses can help reduce healthcare costs by minimizing unnecessary procedures and treatments.
Review
Pediatrics
Vito D'Andrea, Giorgia Prontera, Serena Antonia Rubortone, Lucilla Pezza, Giovanni Pinna, Giovanni Barone, Mauro Pittiruti, Giovanni Vento
Summary: The umbilical venous catheter (UVC) is commonly used in neonates for stable intravenous access, and ultrasound-guided UVC tip location is a simple and learnable technique. However, UVC-related complications are common. Targeted training on the use of point-of-care ultrasound for UVC placement is feasible among neonatal medical staff.
FRONTIERS IN PEDIATRICS
(2022)
Article
Health Care Sciences & Services
Marco Dell'Aquila, Pietro Tralongo, Giuseppe De Ruggieri, Mariangela Curatolo, Luca Revelli, Celestino Pio Lombardi, Alfredo Pontecorvi, Guido Fadda, Luigi Maria Larocca, Marco Raffaelli, Liron Pantanowitz, Esther Diana Rossi
Summary: This study analyzed a cohort of patients with locally advanced thyroid cancer (LATC), including variants of papillary thyroid carcinoma (PTC), to assess their risk for local recurrence, distant metastases, and overall survival. The findings suggest that LATC, including PTC variants, exhibit a more aggressive biological course and should be managed more assertively.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pediatrics
Serena Antonia Rubortone, Simonetta Costa, Alessandro Perri, Vito D'Andrea, Giovanni Vento, Giovanni Barone
Summary: The study aimed to evaluate the effectiveness of a training protocol in improving the use of real-time ultrasound for umbilical venous catheter placement. Results showed a significant increase in the use of real-time ultrasound for tip location after the training program, leading to more accurate placement of catheter tips.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Meeting Abstract
Rheumatology
Enrique Esteve-Valverde, Jaume Alijotas-Reig, Raquel Ferrer-Oliveras, Luis Saez-Comet, Cristina Belizna, Amelia Ruffatti, Angela Tincani, Sara Decarolis, Omar Latino, Ricard Cervera
ANNALS OF THE RHEUMATIC DISEASES
(2019)