Accumulation of FLT3+ CD11c+ dendritic cells in psoriatic lesions and the anti-psoriatic effect of a selective FLT3 inhibitor

Identification of Cellular Pathways of "Type 1," Th17 T Cells, and TNF- and Inducible Nitric Oxide Synthase-Producing Dendritic Cells in Autoimmune Inflammation through Pharmacogenomic Study of Cyclosporine A in Psoriasis

(2014) A. S. Haider et al.   JOURNAL OF IMMUNOLOGY

Low Expression of the IL-23/Th17 Pathway in Atopic Dermatitis Compared to Psoriasis

(2014) E. Guttman-Yassky et al.   JOURNAL OF IMMUNOLOGY

Involvement of IL-9 in Th17-Associated Inflammation and Angiogenesis of Psoriasis

(2013) Tej Pratap Singh et al.   PLoS One

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

(2012) Stanislav Pantelyushin et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I IFNs at the Interface between Cutaneous Immunity and Epidermal Remodeling

(2012) Curdin Conrad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Discovery of the Novel Potent and Selective FLT3 Inhibitor 1-{5-[7-(3- Morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and Its Anti-Acute Myeloid Leukemia (AML) Activities in Vitro and in Vivo

(2012) Wei-Wei Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells

(2012) K. Poppensieker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene mutation and AML pathogenesis

(2011) H. Dombret   BLOOD

Patterns of Molecular Response to and Relapse After Combination of Sorafenib, Idarubicin, and Cytarabine in Patients With FLT3 Mutant Acute Myeloid Leukemia

(2011) Aref Al-Kali et al.   Clinical Lymphoma Myeloma & Leukemia

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

(2011) Yihua Cai et al.   IMMUNITY

Epidermal CCR6 + γδ T Cells Are Major Producers of IL-22 and IL-17 in a Murine Model of Psoriasiform Dermatitis

(2011) Tomotaka Mabuchi et al.   JOURNAL OF IMMUNOLOGY

Identification of a Novel Proinflammatory Human Skin-Homing V 9V 2 T Cell Subset with a Potential Role in Psoriasis

(2011) U. Laggner et al.   JOURNAL OF IMMUNOLOGY

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

A role for interleukin-2 trans-presentation in dendritic cell–mediated T cell activation in humans, as revealed by daclizumab therapy

(2011) Simone C Wuest et al.   NATURE MEDICINE

Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells

(2011) A. W. Lau-Kilby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune functions and recruitment of plasmacytoid dendritic cells in psoriasis

(2010) Cristina Albanesi et al.   AUTOIMMUNITY

The role of antigen presenting cells in multiple sclerosis

(2010) Emily M.L. Chastain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Depletion of antigen-presenting cells by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice

(2010) N.L. Ward et al.   BRITISH JOURNAL OF DERMATOLOGY

8-Methoxypsoralen Plus Ultraviolet A Therapy Acts via Inhibition of the IL-23/Th17 Axis and Induction of Foxp3+ Regulatory T Cells Involving CTLA4 Signaling in a Psoriasis-Like Skin Disorder

(2010) T. P. Singh et al.   JOURNAL OF IMMUNOLOGY

Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis

(2010) Sushmita Sinha et al.   JOURNAL OF NEUROIMMUNOLOGY

Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

(2010) Chen S Tan et al.   LANCET NEUROLOGY

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

(2009) P. P. Zarrinkar et al.   BLOOD

Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis

(2009) M. Skarica et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Skin Disease in K5.hTGF-β1 Transgenic Mice Is Not Dependent on the IL-23/Th17 Inflammatory Pathway

(2009) Erin L. Fitch et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis

(2009) Helia B. Schonthaler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Chronic and Acute Skin Inflammation by Treatment with a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor

(2008) Cornelia Halin et al.   AMERICAN JOURNAL OF PATHOLOGY

FLT3 inhibitors for the treatment of autoimmune disease

(2008) Katharine A Whartenby et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis

(2008) H. Hvid et al.   INTERNATIONAL IMMUNOLOGY