Article
Biochemistry & Molecular Biology
Federica Farina, Laura Pisapia, Mariavittoria Laezza, Gloria Serena, Antonio Rispo, Simona Ricciolino, Carmen Gianfrani, Alessio Fasano, Giovanna Del Pozzo
Summary: Macrophages play a crucial role in the development of celiac disease by expressing CD-associated HLA-DQ2.5 risk alleles differently from other antigen-presenting cells. Gliadin stimulation increases the expression of DQA1*05:01 and decreases the expression of DQB1*02:01 in macrophages, along with downregulation of DRB1 genes and CIITA transactivator.
Article
Chemistry, Analytical
Anna B. N. Nguyen, Marcos Maldonado, Dylan Poch, Tyler Sodia, Andrew Smith, Teisha J. Rowland, Andrew J. Bonham
Summary: Diagnosing celiac disease (CD) is challenging due to overlapping symptoms with other diseases and invasive diagnostics. A proposed less invasive method using an electrochemical DNA biosensor for CD-specific autoantibodies shows promise in detecting CD-specific patient-derived AABs, with the potential to improve diagnostic tools in the future.
Article
Cell Biology
Giuseppe Ercolano, Alex Moretti, Maryline Falquet, Tania Wyss, Ngoc Lan Tran, Isis Senoner, Maddalena Marinoni, Massimo Agosti, Silvia Salvatore, Camilla Jandus, Sara Trabanelli
Summary: The cytokine profile and expansion of ILC precursors in CD patients are associated with low levels of blood vitamin D. Dietary vitamin D supplementation could be a promising therapeutic approach to dampen ILCP-mediated IFN-gamma production.
Article
Pediatrics
Juan-juan Zhang, Jun-qi Wang, Xu Xu, Li-dan Zhang, Cai-ping Zhang, Wen-li Lu, Wei-qiong Gu, Zhi-ya Dong, Yuan Xiao, Zhen-wei Xia
Summary: This study found a high frequency of celiac disease autoantibodies (CDAbs) in Chinese children with type 1 diabetes (T1D). The expression profile of circRNAs in T1D children with CDAbs was different from that of general T1D patients. Hsa_circ_0004564 and its parental gene RAPH1 may be new targets for studying immune mechanisms in children with T1D and celiac disease (CD).
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Min Yin, Yan Zhang, Shanshan Liu, Juan Huang, Xia Li
Summary: This study identified common gene expression changes in target tissues among patients with T1D, HT, and CD, suggesting the importance of shared environmental factors in the pathogenesis of these autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Christian B. Lindstad, M. Fleur du Pre, Jorunn Stamnaes, Ludvig M. Sollid
Summary: The results of the study suggest that secreted anti-TG2 antibodies do not have a direct role in the development of celiac enteropathy.
Article
Biochemistry & Molecular Biology
Michele Sallese, Konstantinos Efthymakis, Michele Marchioni, Benedetto Neri, Beatrice Dufrusine, Enrico Dainese, Marta Di Nicola, Matteo Neri
Summary: Coeliac disease (CeD) is an immune-mediated disorder triggered by gluten, involving autoimmune damage to the intestines and other systems. The Th1 inflammatory response and innate immune response play important roles in its pathogenesis. Gene expression analysis found key cytokines and immune pathways involved. Comparison with non-celiac gluten sensitivity (NCGS) revealed molecular overlap, suggesting a common root (dysregulated long non-coding RNAs) for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Dhruti P. Chen, Claudia P. Aiello, DeMoris McCoy, Taylor Stamey, Jiajin Yang, Susan L. Hogan, Yichun Hu, Vimal K. Derebail, Eveline Y. Wu, J. Charles Jennette, Ronald J. Falk, Dominic J. Ciavatta
Summary: A GWAS identified an association between PR3-ANCA and a SNP (rs62132293) upstream of the PRTN3 gene. The variant (G allele) was shown to be an expression quantitative trait locus in healthy controls, but its clinical impact is still unknown. Patients carrying the variant allele had elevated leukocyte PRTN3 expression compared to non-carriers, while healthy controls had low PRTN3 regardless of genotype.
Article
Genetics & Heredity
Adriaan van der Graaf, Maria M. Zorro, Annique Claringbould, Urmo Vosa, Raul Aguirre-Gamboa, Chan Li, Joram Mooiweer, Isis Ricano-Ponce, Zuzanna Borek, Frits Koning, Yvonne Kooy-Winkelaar, Ludvig M. Sollid, Shuo-Wang Qiao, Vinod Kumar, Yang Li, Lude Franke, Sebo Withoff, Cisca Wijmenga, Serena Sanna, Iris Jonkers
Summary: This study integrated information from a large transcriptomics dataset using multiple methods to identify 118 prioritized genes in 50 CeD-associated regions, showing an association with adaptive and innate cytokine signaling and T cell activation pathways. Additionally, 41 genes were found to be under the control of a master regulator TRAFD1, involved in interferon gamma signaling and MHC I antigen processing. Experimental validation confirmed TRAFD1 as an immune regulator acting in trans and revealed a genetic link between CeD and immune activation pathways.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Mark B. Zimering, Vedad Delic, Bruce A. Citron
Summary: This study found that circulating agonist autoantibodies targeting the 5-hydroxytryptamine 2A receptor, which increase in patients with Parkinson's disease, cognitive decline, and diabetes, can induce gene expression changes related to mitochondrial function, immune function, and cell death in neuroblastoma cells.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Maarit Oikarinen, Leena Puustinen, Jussi Lehtonen, Leena Hakola, Satu Simell, Jorma Toppari, Jorma Ilonen, Riitta Veijola, Suvi M. Virtanen, Mikael Knip, Heikki Hyoty
Summary: Enterovirus infections may contribute to the development of celiac disease, especially before the appearance of celiac disease-related autoantibodies. Adenovirus infections do not seem to have a significant association with the development of celiac disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Elena Maria Domsa, Ioana Berindan-Neagoe, Livia Budisan, Cornelia Braicu, Ioana Para, Alina Ioana Tantau, Olga Hilda Orasan, Lidia Ciobanu, Teodora Atena Pop, Gabriela Adriana Filip, Nicoleta Leach, Vasile Negrean, Daniela Matei, Vasile Andreica
Summary: This study aimed to investigate the expression of selected genes and miRNAs in adult CD patients. The results showed significant overexpression of TNFα, MAPK1, and CCND1 in newly diagnosed CD patients compared to controls. Further studies are needed to explore the potential of these genes and miRNAs as biomarkers in clinical practice.
MEDICINA-LITHUANIA
(2022)
Article
Dermatology
S. Assaf, L. Malki, T. Mayer, J. Mohamad, A. Peled, M. Pavlovsky, K. Malovitski, O. Sarig, D. Vodo, E. Sprecher
Summary: The study elucidates the mechanism through which ST18 contributes to destabilization of cell-cell adhesion in PV, showing that ST18 directly activates the TNF promoter to disrupt cell adhesion. Enhanced expression of ST18 and TNF-alpha in the skin of PV patients with an ST18-associated risk variant is associated with a more severe PV phenotype, suggesting a role for TNF-alpha in mediating the deleterious effects of increased ST18 expression in PV skin.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Renata Auricchio, Martina Galatola, Donatella Cielo, Roberta Rotondo, Fortunata Carbone, Roberta Mandile, Martina Carpinelli, Serena Vitale, Giuseppe Matarese, Carmen Gianfrani, Riccardo Troncone, Salvatore Auricchio, Luigi Greco
Summary: This study explored the relationship between antibody production in genetically susceptible individuals and systemic inflammation in celiac disease. The early and isolated production of anti-native gliadin-IgA antibodies may be a marker of tolerance to deamidated gliadin and tissue transglutaminase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Marco Valvano, Stefano Fabiani, Sabrina Monaco, Mauro Calabro, Antonio Mancusi, Sara Frassino, Claudia Rolandi, Marta Mosca, Susanna Faenza, Emanuele Sgamma, Nicola Cesaro, Giovanni Latella
Summary: Celiac disease is a chronic enteropathy caused by gluten ingestion in genetically susceptible individuals. The only recommended treatment is a gluten-free diet, but unintentional gluten ingestion or refractory celiac disease with persistent villous atrophy poses a major challenge. This review analyzed data from randomized controlled trials and observational studies to evaluate adjunctive and novel therapies for CD and RCD. Although a gluten-free diet remains the only effective treatment, steroids, mesalamine, and biological therapies have shown promise in managing RCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Rheumatology
I. Pagnini, C. Bason, G. Simonini, T. Giani, A. Brucato, C. Lunardi, R. Cimaz
ANNALS OF THE RHEUMATIC DISEASES
(2015)
Article
Rheumatology
M. Dolcino, A. Puccetti, A. Barbieri, C. Bason, E. Tinazzi, A. Ottria, G. Patuzzo, N. Martinelli, C. Lunardi
Article
Plant Sciences
Elisa Nazzi, Matilde Merlin, Caterina Basonl, Ruggero Ben, Roberta Zampieri, Chiara Lico, Elena Bartoloni, Antonio Puccetti, Claudio Lunardil, Mario Pezzotti, Linda Avesani
FRONTIERS IN PLANT SCIENCE
(2015)
Article
Rheumatology
C. Bason, I. Pagnini, A. Brucato, S. Maestroni, A. Puccetti, C. Lunardi, R. Cimaz
Article
Immunology
Elettra Berti, Gaia Vannucci, Claudio Lunardi, Benedetta Bianchi, Caterina Bason, Antonio Puccetti, Teresa Giani, Ilaria Pagnini, Rolando Cimaz, Gabriele Simonini
Article
Hematology
Elisa Ciraci, Silvia Della Bella, Ombretta Salvucci, Cristina Rofani, Marta Segarra, Caterina Bason, Agnese Molinari, Dragan Maric, Giovanna Tosato, Anna C. Berardi
Article
Immunology
Elisabetta Traggiai, Claudio Lunardi, Caterina Bason, Marzia Dolcino, Elisa Tinazzi, Roberto Corrocher, Antonio Puccetti
INTERNATIONAL IMMUNOLOGY
(2010)
Article
Immunology
Rocco Pastano, Chiara Dell'Agnola, Caterina Bason, Federica Gigli, Cristina Rabascio, Antonio Puccetti, Elisa Tinazzi, Gianluigi Cetto, Fedro Peccatori, Giovanni Martinelli, Claudio Lunardi
INTERNATIONAL IMMUNOLOGY
(2012)
Article
Medicine, General & Internal
C. Lunardi, C. Bason, M. Dolcino, R. Navone, R. Simone, D. Saverino, L. Frulloni, E. Tinazzi, D. Peterlana, R. Corrocher, A. Puccetti
JOURNAL OF INTERNAL MEDICINE
(2009)
Article
Multidisciplinary Sciences
Caterina Bason, Renata Lorini, Claudio Lunardi, Marzia Dolcino, Alessandro Giannattasio, Giuseppe d'Annunzio, Antonella Rigo, Nicoletta Pedemonte, Roberto Corrocher, Antonio Puccetti
Review
Immunology
Elisa Tinazzi, Nicola Osti, Ruggero Beri, Giuseppe Argentino, Dino Veneri, Francesco Dima, Caterina Bason, Gnaneshwer Jadav, Marzia Dolcino, Antonio Puccetti, Claudio Lunardi
AUTOIMMUNITY REVIEWS
(2020)
Article
Immunology
Caterina Bason, Alessandro Barbieri, Nicola Martinelli, Bianca Olivieri, Giuseppe Argentino, Elena Bartoloni, Ruggero Beri, Gnaneshwer Jadav, Antonio Puccetti, Elisa Tinazzi, Claudio Lunardi
Summary: A specific peptide recognized by RA patients' sera was identified through screening, which was not recognized by healthy subjects or patients with other immune-mediated diseases. This peptide may serve as a novel serum biomarker for seronegative RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giuseppe Argentino, Alessandro Barbieri, Ruggero Beri, Caterina Bason, Andrea Ruzzenente, Oliviero Olivieri, Elisa Tinazzi, Antonio Puccetti, Claudio Vitali, Nicoletta Del Papa, Simonetta Friso, Claudio Lunardi
Summary: This study found that endothelin-1 (ET-1) indirectly induces the production of reactive oxygen species (ROS) by stimulating aldosterone production in fibroblasts, which may play a pivotal role in the pathogenesis of systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH).
Article
Biochemistry & Molecular Biology
Antonina Parafioriti, Caterina Bason, Elisabetta Armiraglio, Lucia Calciano, Primo Andrea Daolio, Martina Berardocco, Andrea Di Bernardo, Alessia Colosimo, Roberto Luksch, Anna C. Berardi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)