Genetics of antigen processing and presentation

ElevatedHLA-Aexpression impairs HIV control through inhibition of NKG2A-expressing cells

(2018) Veron Ramsuran et al.   SCIENCE

Identification of an elaborate NK-specific system regulating HLA-C expression

(2018) Hongchuan Li et al.   PLoS Genetics

Crystal structure of a TAPBPR–MHC I complex reveals the mechanism of peptide editing in antigen presentation

(2017) Jiansheng Jiang et al.   SCIENCE

Structural and regulatory diversity shape HLA-C protein expression levels

(2017) Gurman Kaur et al.   Nature Communications

TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

(2017) Andreas Neerincx et al.   eLife

Single molecule real-time DNA sequencing of HLA genes at ultra-high resolution from 126 International HLA and Immunogenetics Workshop cell lines

(2017) T. R. Turner et al.   HLA

Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing

(2016) Paul J. Norman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

(2016) Richard T. Timms et al.   Nature Communications

Co-evolution with chicken class I genes

(2015) Jim Kaufman   IMMUNOLOGICAL REVIEWS

Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity

(2015) Clive A. Tregaskes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reply to Robinson and Brown: It is the combination ofERAP1allotypes that identifies individuals with Ankylosing Spondylitis

(2015) Emma Reeves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERAP1 biology and assessment in Ankylosing Spondylitis

(2015) Philip C. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst

(2015) Clemens Hermann et al.   eLife

HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation

(2014) E. W. Petersdorf et al.   BLOOD

ERAP1 in the pathogenesis of ankylosing spondylitis

(2014) Emma Reeves et al.   IMMUNOLOGIC RESEARCH

TAPBPR isoforms exhibit altered association with MHC class I

(2014) Keith M. Porter et al.   IMMUNOLOGY

Functionally distinctERAP1allotype combinations distinguish individuals with Ankylosing Spondylitis

(2014) Emma Reeves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of HLA-C Expression Level on HIV Control

(2013) R. Apps et al.   SCIENCE

Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27

(2013) Liye Chen et al.   Arthritis & Rheumatology

NLRC5, at the Heart of Antigen Presentation

(2013) Andreas Neerincx et al.   Frontiers in Immunology

NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells

(2012) F. Staehli et al.   JOURNAL OF IMMUNOLOGY

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism

(2012) Abigail I Guce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation

(2011) Petra Paul et al.   CELL

Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility

(2011) Malgorzata Anna Garstka et al.   FASEB JOURNAL

Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes

(2011) S. Badrinath et al.   HAEMATOLOGICA

Differential microRNA regulation of HLA-C expression and its association with HIV control

(2011) Smita Kulkarni et al.   NATURE

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project

(2008) Roger Horton et al.   IMMUNOGENETICS