Article
Immunology
Jose Luis Rodriguez-Fernandez, Olga Criado-Garcia
Summary: Chemoattraction is the migration of cells towards a chemical gradient, controlled by chemoattractant receptors. Directional sensing and actin-based motility are the two basic activities involved in chemoattraction, and recent research suggests that they can be independently regulated.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jong Min Hong, Jin-Woo Lee, Dong-Seung Seen, Jae-Yeon Jeong, Won-Ki Huh
Summary: The heteromerization between CXCR4 and LPA1 has been investigated, showing its important role in cancer cells and providing insights into the regulatory mechanism of CXCR4 through heteromer formation. The findings suggest a potential therapeutic approach using combined CXCR4 and LPA1 inhibitors for cancer and inflammatory diseases associated with these receptors.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Francesca Sozio, Tiziana Schioppa, Mattia Laffranchi, Valentina Salvi, Nicola Tamassia, Francisco M. Bianchetto-Aguilera, Laura Tiberio, Raffaella Bonecchi, Daniela Bosisio, Marc Parmentier, Barbara Bottazzi, Roberto Leone, Eleonora Russo, Giovanni Bernardini, Stefano Garofalo, Cristina Limatola, Angela Gismondi, Giuseppe Sciume, Alberto Mantovani, Annalisa Del Prete, Silvano Sozzani
Summary: Patterns of receptors play a crucial role in regulating the homing of leukocytes. A study reveals that the CCRL2/chemerin/CMKLR1 axis acts as a selective pathway for the homing of NK cells to the lung. Inactivation of CCRL2 or its ligand chemerin promotes lung tumor growth by affecting the recruitment of NK cells, while other receptors identified in lung-infiltrating NK cells are dispensable for this process.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Cell Biology
Yihong Yang, Dong Li, Xiaoting Chao, Shashi P. Singh, Peter Thomason, Yonghong Yan, Mengqiu Dong, Lei Li, Robert H. Insall, Huaqing Cai
Summary: This study identifies a novel polarity regulator, Leep1, in the model system Dictyostelium, which selectively localizes at the leading edge of cells by binding to PIP3 to negatively regulate the Scar/WAVE complex, thereby modulating the dynamics of protrusive structures at the leading edge.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Cell Biology
Shuvasree SenGupta, Carole A. Parent, James E. Bear
Summary: Cells are capable of sensing various signals and migrating towards or away from them, involving signal generation, sensing, transduction, and polarized force generation. Understanding the mechanisms underlying cell migration is crucial for understanding migration in vivo.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Article
Pathology
Gun-Dong Kim, Hang Pong Ng, E. Ricky Chan, Ganapati H. Mahabeleshwar
Summary: Macrophages play crucial roles in inflammatory vascular diseases, and deficiency of HIF1α may attenuate vascular smooth muscle cells and macrophage abundance, reducing inflammation in stenotic arteries. HIF1α regulates various metabolic and inflammatory signaling pathways in macrophages.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carolina M. Polonio, Patrick da Silva, Fabiele B. Russo, Brendo R. N. Hyppolito, Nagela G. Zanluqui, Cecilia Benazzato, Patricia C. B. Beltrao-Braga, Sandra M. Muxel, Jean Pierre S. Peron
Summary: Viral infections, particularly Zika virus, have a significant impact on public health, causing severe fetal neuropathogenesis and microcephaly. MiRNAs play a role in infected neuronal precursor cells and directly contribute to the pathogenesis of fetal microcephaly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Junyong Wang, Junpeng Ma, Hongyu Nie, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Hongliang Li, Yan-Xiao Ji, Jingjing Cai
Summary: The study found that RGS5 protects against NAFLD and nonalcoholic steatohepatitis, and that it is negatively associated with mitogen-activated protein kinase signaling cascades in response to metabolic challenges. RGS5 directly interacts with TAK1, inhibits its hyperphosphorylation, and prevents the activation of the downstream JNK/p38 signaling cascade.
Article
Cell Biology
Woo Yong Park, Gahee Song, Ja Yeon Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jinbong Park, Jun Hee Lee, Jae-Young Um
Summary: In this study, the therapeutic efficacy of ellagic acid (EA) for benign prostate hyperplasia (BPH) was investigated. EA was found to improve BPH by inhibiting the AR signaling axis and STAT3 pathway. EA reduced prostate weight, epithelial thickness, and serum DHT levels in BPH rats. It also improved testicular injury and induced apoptosis in prostate cells.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Yi-Shin Wu, Chian-Ruei Chen, Yun-Ting Yeh, Han-Huei Lin, Yin-Hsuan Peng, Yu-Ling Lin
Summary: DMGF inhibits the production of proinflammatory cytokines and the migration of inflammatory cells, potentially through downregulation of estrogen receptor alpha signaling.
Article
Multidisciplinary Sciences
Thomas Tran, Aruni P. K. K. Karunanayake Mudiyanselage, Stephen J. Eyles, Lynmarie K. Thompson
Summary: Motile bacteria can sense their environment and swim towards favorable conditions using a chemotaxis system. In this system, ligand binding to the chemoreceptor triggers a phosphorylation cascade that controls flagellar rotation. By studying functional signaling complexes in E. coli, it was found that stabilization/destabilization of certain domains in CheA is crucial for modulating its kinase activity in chemotaxis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Wiebke Nadolni, Roland Immler, Kilian Hoelting, Marco Fraticelli, Myriam Ripphahn, Simone Rothmiller, Masayuki Matsushita, Ingrid Boekhoff, Thomas Gudermann, Markus Sperandio, Susanna Zierler
Summary: The study demonstrates the functional expression of TRPM7 in neutrophils and its impact on neutrophil recruitment during inflammation. Blocking TRPM7 channel or kinase activity affects neutrophil function, indicating a potential target to treat excessive neutrophil invasion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hui Chen, Mindy Smith, Jasmin Herz, Tong Li, Rebecca Hasley, Cecile Le Saout, Ziang Zhu, Jie Cheng, Andres Gronda, Jose A. Martina, Pablo M. Irusta, Tatiana Karpova, Dorian B. McGavern, Marta Catalfamo
Summary: PAR1 activation in CD8 T cells accelerates calcium mobilization, facilitates granule trafficking through actin polymerization, and repositions the microtubule organizing center toward the immunological synapse. Mice lacking PAR1 exhibit reduced cytokine-producing T cells in response to viral infection, and specific deletion of PAR1 in LCMV GP33-specific CD8 T cells results in diminished expansion and effector function. These findings suggest that PAR1 plays a crucial role in T cell activation and function, offering a new therapeutic strategy to modulate CD8 T cell effector function.
Article
Multidisciplinary Sciences
Jong Min Choi, Seung Eun Baek, Ji On Kim, Eun Yeong Jeon, Eun Jeong Jang, Chi Dae Kim
Summary: In injured vasculatures, 5-LO-derived LTB4 plays a key role in MCP-1 expression in HMGB1-exposed VSMCs via BLTR1 signaling, suggesting the LTB4-BLTR1 signaling axis as a potential therapeutic target for vascular inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Daniel Bastardo Blanco, Nicole M. Chapman, Jana L. Raynor, Chengxian Xu, Wei Su, K. C. Anil, Wei Li, Seon Ah Lim, Stefan Schattgen, Hao Shi, Isabel Risch, Yu Sun, Yogesh Dhungana, Yunjung Kim, Jun Wei, Sherri Rankin, Geoffrey Neale, Paul G. Thomas, Kai Yang, Hongbo Chi
Summary: PTEN loss leads to the accumulation of type-17 innate-like T cells through altered metabolic reprogramming and the involvement of mTOR, Foxo1, and IL-23-Stat3 signaling.
NATURE CELL BIOLOGY
(2022)