Journal
IMMUNOBIOLOGY
Volume 217, Issue 7, Pages 743-748Publisher
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2011.12.009
Keywords
Silica; Autoimmune; Systemic sclerosis; CD95/Fas; Regulatory T cell
Categories
Funding
- Special Coordination Funds for Promoting Science and Technology [H18-1-3-3-1]
- KAKENHI [18390186, 19659153, 20390178]
- Kawasaki Medical School [18-601, 19-603T, 20-410I, 20-603, 21-606, 22-A7]
- Sumitomo Foundation [053027]
- Yasuda Memorial Foundation [H18]
- Takeda Science Foundation [I-2008]
- Japanese Society of Hygiene [H18]
- Grants-in-Aid for Scientific Research [22790550, 23890237, 24590770] Funding Source: KAKEN
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Autoimmune disorders are induced by various environmental and occupational substances. Among the most typical factors involving these substances, it is well known that silica exposure causes not only pulmonary fibrosis known as silicosis, but also induces autoimmune diseases such as rheumatoid arthritis known as Caplan's syndrome, systemic sclerosis, systemic lupus erythematosus, and anti-neutrophil cytoplasmic autoantibody (ANCA)-related vasculitis/nephritis. To investigate the immunological effects of silica, a focus on the occurrence of autoimmune dysfunction may clarify these autoimmune diseases and develop effective tools for observing silicosis patients (SIL). In this review, our investigation concerns the autoantibodies found in SIL, alteration of CD95/Fas and related molecules in SIL, case-oriented and in vitro analyses of silica-induced activation of responder and regulatory T cells, and supposed mechanisms of reduction of CD4 + 25 + FoxP3+ regulatory T cells (T-reg) in SIL Further studies are required to investigate Th17 and the interaction with T-reg in SIL to understand the cellular and molecular mechanisms of environmental and occupational autoimmune disorders. (C) 2011 Elsevier GmbH. All rights reserved.
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