Article
Immunology
Sining Zhu, Almin I. Lalani, Juan Jin, Derek Sant'Angelo, Lori R. Covey, Kebin Liu, Howard A. Young, Suzanne Ostrand-Rosenberg, Ping Xie
Summary: Myeloid-derived suppressor cells (MDSCs), recognized as a prime therapeutic target in cancer, are found to be critically restrained by the adaptor protein TRAF3, which inhibits MDSC expansion via both cell-intrinsic and cell-extrinsic mechanisms. This study provides novel insights into the complex regulatory mechanisms of MDSC expansion and opens up unique perspectives for targeting MDSCs in cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jiawei Li, Juntao Chen, Mingnan Zhang, Chao Zhang, Renyan Wu, Tianying Yang, Yue Qiu, Jingjing Liu, Tongyu Zhu, Yi Zhang, Ruiming Rong
Summary: The study found that mTOR deficiency enhances the immunosuppressive function of monocytic MDSCs and prolongs the survival time of mouse cardiac transplantation, mainly manifested as promoting MDSC differentiation, increasing intracellular autophagy levels, and inhibiting T cell activation and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
M. Elizabeth Deerhake, Keiko Danzaki, Makoto Inoue, Emre D. Cardakli, Toshiaki Nonaka, Nupur Aggarwal, William E. Barclay, Ru-Rong Ji, Mari L. Shinohara
Summary: This study revealed that Dectin-1 limits experimental autoimmune encephalomyelitis (EAE) by inducing the gene expression of the neuroprotective molecule Osm through a Card9-independent pathway. The Osm receptor functions in astrocytes to reduce EAE severity. The study introduces a mechanism of beneficial myeloid cell-astrocyte crosstalk regulated by a Dectin-1 pathway.
Article
Oncology
Yutaka Sugita, Kimihiro Yamashita, Mitsugu Fujita, Masafumi Saito, Kota Yamada, Kyosuke Agawa, Akihiro Watanabe, Eiji Fukuoka, Hiroshi Hasegawa, Shingo Kanaji, Taro Oshikiri, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
Summary: Recent research has shown that the increase of PMN-MDSCs is closely associated with the progression of peritoneal dissemination (PD) in colorectal cancer (CRC). Targeted therapy for PMN-MDSCs using anti-Ly6G monoclonal antibody significantly inhibits PD progression and restores CD4(+) and CD8(+) T cells in the peritoneal cavity and peripheral blood.
Article
Cell Biology
Meike von Wulffen, Veronika Luehrmann, Stefanie Robeck, Antonella Russo, Lena Fischer-Riepe, Martijn van den Bosch, Peter van Lent, Karin Loser, Dmitry I. Gabrilovich, Sven Hermann, Johannes Roth, Thomas Vogl
Summary: This study demonstrates the crucial role of endogenous alarmin S100A8/A9 in autoimmune arthritis by reprogramming myeloid cells to a T cell suppressing phenotype. The reprogramming process is dependent on Toll-like receptor 4.
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Zhaonian Hao, Ruyuan Li, Yuanyuan Wang, Shuangying Li, Zhenya Hong, Zhiqiang Han
Summary: MDSC play vital roles in cancer microenvironment, influencing the responses to immunotherapies and prognosis of cancer patients. Therefore, proposing MDSC-inhibiting strategies becomes crucial in the field of cancer immunotherapies.
BIOMARKER RESEARCH
(2021)
Article
Oncology
Yao Tang, Cong Zhou, Qingli Li, Xiaojiao Cheng, Tinglei Huang, Fuli Li, Lina He, Baiweng Zhang, Shuiping Tu
Summary: This study highlights the potential of combining PD-L1 blockade therapy with agonistic anti-DR5 antibody to target MDSCs in gastric and colon cancers. Targeting DR5 effectively depleted MDSCs, increased CD8(+) T lymphocytes in tumors, and showed synergistic antitumor effects when combined with anti-PD-L1 antibody. The combination therapy also induced sustained memory immunity and enhanced CD8(+) T-cell infiltration and activation in tumors, resulting in significant tumor growth suppression and prolonged survival in mice.
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Iosif Papafragkos, Efrosyni Markaki, Christina Kalpadakis, Panayotis Verginis
Summary: Myeloid-derived suppressor cells (MDSCs) are potent regulators of the immune system, playing a role in cancer but their specific contribution to lymphomas remains unclear. This review focuses on MDSCs in lymphomas, discussing literature and lessons learned from animal models, and highlights future research directions and challenges in understanding the immune system complexities in malignancies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Adam N. R. Cartwright, Shengbao Suo, Soumya Badrinath, Sushil Kumar, Johannes Melms, Adrienne Luoma, Archis Bagati, Assieh Saadatpour, Benjamin Izar, Guo-Cheng Yuan, Kai W. Wucherpfennig
Summary: The study demonstrates that MDSCs do not block early steps of T-cell activation but induce DNA damage and p53 pathway activation in CD8(+) T cells through an iNOS-dependent pathway.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Taosan Li, Fang Zheng, Fanjun Cheng
Summary: This article analyzes the role of MDSCs in lymphopenia in COVID-19 patients and discusses their immunopathologic changes and potential therapeutic targets.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Estefania Prochetto, Eliana Borgna, Carlos Jimenez-Cortegana, Victor Sanchez-Margalet, Gabriel Cabrera
Summary: Myeloid-derived suppressor cells (MDSCs) play a role in both pathological and non-pathological conditions, including cancer, infections, pregnancy, aging, and vaccination. Vaccination is a crucial public health measure, but the presence of MDSCs may impact vaccine efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Liraz Shmuel-Galia, Fiachra Humphries, Xuqiu Lei, Simona Ceglia, Ruth Wilson, Zhaozhao Jiang, Natalia Ketelut-Carneiro, Sage E. Foley, Susanne Pechhold, JeanMarie Houghton, Khaja Muneeruddin, Scott A. Shaffer, Beth A. McCormick, Andrea Reboldi, Doyle Ward, Ann Marshak-Rothstein, Katherine A. Fitzgerald
Summary: Alterations in the cGAS-STING DNA-sensing pathway can affect intestinal homeostasis and lead to inflammation. Increased STING expression is a feature of intestinal inflammation in both mice with colitis and humans with inflammatory bowel disease. STING accumulation in intestinal myeloid cells can be triggered by dysbiosis and bacterial products, leading to a positive feedback loop that drives intestinal inflammation.
Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Article
Biochemistry & Molecular Biology
Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Weiya Xia, Boning Liu, Yu-Yi Chu, Laura Bover, Long Vien, Mien-Chie Hung
Summary: This study reports the development of two novel Gal-9-neutralizing antibodies that effectively protect human T cells from Gal-9-induced cell death and promote T cell-mediated killing of tumor cells. These findings demonstrate the potential of targeting Gal-9 for cancer immunotherapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Haige Ye, Shengjian Huang, Yang Liu, Zhihong Chen, Michael Wang, Vivian Changying Jiang
Summary: This study focuses on identifying the signalling network rewiring that characterizes the ibrutinib resistant phenotype. Dual targeting of the BCL-2 and PI3-kinase signalling pathways shows significant anti-tumour activity by inhibiting compensatory pathways and inducing apoptosis in MCL.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jian Tu, Zijun Huo, Yao Yu, Dandan Zhu, An Xu, Mo-Fan Huang, Ruifeng Hu, Ruoyu Wang, Julian A. Gingold, Yi-Hung Chen, Kuang-Lei Tsai, Nicolas R. Forcioli-Conti, Sarah X. L. Huang, Thomas R. Webb, Jie Su, Danielle A. Bazer, Peilin Jia, Jason T. Yustein, Lisa L. Wang, Mien-Chie Hung, Zhongming Zhao, Chad D. Huff, Jingnan Shen, Ruiying Zhao, Dung-Fang Lee
Summary: The study reveals that the spliceosome is an up-regulated target in RB1-mutant cells responding to oncogenic stress, and pRB and E2F3a coregulate spliceosomal gene expression, affecting cell proliferation and tumorigenesis. These findings suggest that the spliceosomal machinery could be a potential therapeutic vulnerability for pRB-deficient cancers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Li-Li Feng, Shu-Ying Bie, Li Gong, Fang Wang, Ming-Biao Wei, Wei-Xing Feng, Xiao-Lin Pang, Cao-Litao Qin, Xin-Ke Yin, Ying-Nai Wang, Weihua Zhou, Daniel R. Wahl, Quentin Liu, Ming Chen, Mien-Chie Hung, Xiang-Bo Wan
Summary: MRNIP forms liquid-like condensates to promote DSB repair. It concentrates the MRN complex to the damaged DNA in the nucleus, accelerating DSB sensing and end resection.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wei-Jan Wang, Yeh Chen, Wen-Chi Su, Yen-Yi Liu, Wan-Jou Shen, Wei-Chao Chang, Sheng-Teng Huang, Cheng-Wen Lin, Yu-Chuan Wang, Chia-Shin Yang, Mei-Hui Hou, Yu-Chi Chou, Yang-Chang Wu, Shao-Chun Wang, Mien-Chie Hung
Summary: In this study, we identified a naturally derived compound called peimine, extracted from Fritillaria, that can inhibit viral infection of SARS-CoV-2 variants of concern (VOCs) in lung cells. Peimine blocks viral entry by interfering with the interaction between the spike protein and ACE2. Molecular docking analysis showed that peimine has a strong binding affinity for the N501Y mutation in the spike protein. Furthermore, Fritillaria was found to significantly inhibit SARS-CoV-2 viral infection. These findings suggest that peimine and Fritillaria could be potential drugs and food sources for COVID-19 patients.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Cell Biology
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Yan Ma, Xin-Ke Yin, Li-Li Feng, Guang-Dong Zeng, Fang Wang, Wei-Xing Feng, Jian Zheng, Ying-Nai Wang, Bing Zeng, Quentin Liu, Mien-Chie Hung, Xiang-Bo Wan
Summary: The research revealed the crucial role of radiation-induced paraspeckles in DNA repair and tumor radioresistance, offering a new insight into the ribosome-independent function of ribosomal proteins.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Rodney Cheng-En Hsieh, Sunil Krishnan, Ren-Chin Wu, Akash R. Boda, Arthur Liu, Michelle Winkler, Wen-Hao Hsu, Steven Hsesheng Lin, Mien-Chie Hung, Li-Chuan Chan, Krithikaa Rajkumar Bhanu, Anupallavi Srinivasamani, Ricardo Alexandre De Azevedo, Yung-Chih Chou, Ronald A. DePinho, Matthew Gubin, Eduardo Vilar, Chao Hsien Chen, Ravaen Slay, Priyamvada Jayaprakash, Shweta Mahendra Hegde, Genevieve Hartley, Spencer T. Lea, Rishika Prasad, Brittany Morrow, Coline Agnes Couillault, Madeline Steiner, Chun-Chieh Wang, Bhanu Prasad Venkatesulu, Cullen Taniguchi, Yon Son Betty Kim, Junjie Chen, Nils-Petter Rudqvist, Michael A. Curran
Summary: Radiation therapy induces up-regulation of CD47 and PD-L1 through the ATR-mediated DNA repair signaling pathway in CRC cells, which limits TAA cross-presentation and immune activation. Combination therapy with anti-SIRP alpha and anti-PD-1 reverses immune resistance, promotes TAA cross-presentation and robust antitumor immune priming.
SCIENCE IMMUNOLOGY
(2022)
Article
Oncology
Yu-Yi Chu, Mei-Kuang Chen, Yongkun Wei, Heng-Huan Lee, Weiya Xia, Ying-Nai Wang, Clinton Yam, Jennifer L. Hsu, Hung-Ling Wang, Wei-Chao Chang, Hirohito Yamaguchi, Zhou Jiang, Chunxiao Liu, Ching-Fei Li, Lei Nie, Li-Chuan Chan, Yuan Gao, Shao-Chun Wang, Jinsong Liu, Shannon N. Westin, Sanghoon Lee, Anil K. Sood, Liuqing Yang, Gabriel N. Hortobagyi, Dihua Yu, Mien-Chie Hung
Summary: This study reveals that anaplastic lymphoma kinase (ALK) phosphorylates CDK9 at tyrosine-19, leading to homologous recombination repair and resistance to PARP inhibitors. Combining ALK and PARP inhibitors shows promising results in reducing tumor growth and improving survival. The expression of phosphorylated ALK is associated with resistance to PARP inhibitors.
Article
Oncology
Yi-Chuan Li, Hirohito Yamaguchi, Yen-Yi Liu, Kai-Cheng Hsu, Ting-Hsuan Sun, Pei-Chi Sun, Mien-Chie Hung
Summary: This article investigates the interaction between ribonuclease 1 (RNase1) and EphA4 and reveals their structure and role in cellular activation. The study suggests that electrostatic force plays a crucial role in the binding and activation of RNase1 and EphA4.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Chun-Te Ho, Shih-Pei Lin, Ling-Ming Tseng, Mien-Chie Hung, Shih-Chieh Hung
Summary: This study found that a mutant form of Snail reduced the expression of Src in luminal A breast cancer cells and enhanced their migration and invasion abilities, while reducing their capacity to form tumor spheres. Additionally, human luminal A breast cancer samples showed a negative correlation between Vimentin and Src expression.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chen-Shiou Wu, Hsiu-Mei Chiang, Yeh Chen, Chung-Yu Chen, Hsiao-Fan Chen, Wen-Chi Su, Wei-Jan Wang, Yu-Chi Chou, Wei-Chao Chang, Shao-Chun Wang, Mien-Chie Hung
Summary: This research explores natural plant extracts that have the potential to combat SARS-CoV-2 and provide alternative options for prevention and disinfection. The study identifies coffee leaf extract as an effective inhibitor of SARS-CoV-2 infection in various strains. Additionally, the extract proves to be more potent at preventing viral entry into cells when applied topically than the standard disinfectant ethanol. Compounds such as caffeine, chlorogenic acid, quinic acid, and mangiferin are found to be associated with the extract's antiviral activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Poyee Lau, Guanxiong Zhang, Shuang Zhao, Long Liang, Hailun Zhang, Guowei Zhou, Mien-Chie Hung, Xiang Chen, Hong Liu
Summary: This study reveals the important role of SPHK1 in tumor immunity and shows that its inhibition can suppress tumor growth and promote antitumor immunity. Additionally, SPHK1 and MTA3 are identified as biological markers for predicting the efficacy of anti-PD-1 mAb therapy in melanoma patients.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Oncology
Zhen Xue, Shuang Zheng, Dongli Linghu, Boning Liu, Yi Yang, Mei-Kuang Chen, Hua Huang, Jiaming Song, Hongyue Li, Jing Wang, Mien-Chie Hung, Diansheng Zhong, Linlin Sun
Summary: PD-L1 plays a crucial role in DNA damage repair in cancer cells and can enhance the efficacy of existing immunotherapy by modulating pathways related to innate immunity.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Fu Ou-Yang, Chung-Liang Li, Chia-Chi Chen, Yi-Chun Shen, Sin-Hua Moi, Chi-Wen Luo, Wei-Ya Xia, Ying-Nai Wang, Heng-Huan Lee, Lu-Hai Wang, Shao-Chun Wang, Mei-Ren Pan, Ming-Feng Hou, Mien-Chie Hung
Summary: This study found that de-glycosylation of tumor cell surface PD-L1 staining is significantly correlated with clinical response in atezolizumab treatment for breast cancer. These findings suggest that de-glycosylation procedure may serve as a patient stratification strategy and should be further explored.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
David J. H. Shih, Mei-Kuang Chen, Jun Yin, Daniel J. McGrail, Hui Dai, Rongbin Wei, Jing Zhang, Wenjin Jim Zheng, Kim-Anh Do, Liuqing Yang, Mien-Chie Hung, Shiaw-Yih Lin
Summary: This study developed a bioinformatic strategy for identifying candidate drugs to overcome acquired resistance in cancer treatment. By analyzing transcriptomic data and compound perturbation profiles, the authors discovered a transcriptional adaptation deficiency in resistant clones of breast cancer cells treated with PARP inhibitors. They successfully validated the vulnerability induced by this deficiency and suggested a new strategy for precision oncology.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
