Article
Immunology
Juan He, Yu Li, Jian Chen, Qi Wu, Hongying Shan, Xiaocheng Wang, Miaomiao Zhang, Liping Nie, Qingwen Wang
Summary: Different subsets of CD8+ T cells are associated with clinical features and serological parameters in rheumatoid arthritis (RA). Naive CD8+ T cells are negatively correlated with disease activity, while CD8+ CD28-T cells and CD8+ CD27-T cells are positively correlated with disease activity. Activated CD8+ T cells and TCR gamma E+ CD8+ T cells may be involved in inflammation and lipid metabolism in RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Sumapa Chaiamnuay, Srisakul Jiemjit, Wipatcharin Songdechaphipat, Pongthorn Narongroeknawin, Rattapol Pakchotanon, Paijit Asavatanabodee
Summary: This study identifies predictors of rheumatoid arthritis (RA) disease activity flare in patients who achieved low disease activity (LDA) or persistent remission. Early and aggressive treatment with disease-modifying antirheumatic drugs (DMARDs) can help maintain remission, especially in seropositive patients. Tapering of DMARDs should be done minimally 6 months after reaching remission.
Review
Immunology
Yuan Qu, Yang Fu, Yuan Liu, Chuanguo Liu, Bing Xu, Qian Zhang, Ping Jiang
Summary: Transient receptor potential cation channel subfamily V member 1 (TRPV1) has been found to play a role in immune regulation and its dysregulation affects the development of rheumatoid arthritis. Understanding the mechanism of TRPV1 can lead to the design of new drugs and improved treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Farzin Khosrow-Khavar, Seoyoung C. Kim, Hemin Lee, Su Been Lee, Rishi J. Desai
Summary: The study did not find evidence of increased cardiovascular risk with tofacitinib in patients with RA in a real-world setting. However, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Kristin Schmiedeberg, Irene A. Abela, Natalia Barbara Pikor, Nicolas Vuilleumier, Magdalena Schwarzmueller, Selina Epp, Sabrina Pagano, Sarah Grabherr, Angelica Brooke Patterson, Madalina Nussberger, Alexandra Trkola, Burkhard Ludewig, Johannes von Kempis, Andrea Rubbert-Roth
Summary: There is a correlation between immune responses following a two-dose regimen of mRNA anti-SARS-CoV-2 vaccines in patients with rheumatoid arthritis (RA) and the development of potent neutralising antiviral activity. Patients with RA show slower development of IgG responses, while IgA and IgM responses persist. Anti-S IgG levels 2 weeks after the second vaccine dose are significantly correlated with the development of potent neutralising activity after 12 and 24 weeks.
Article
Rheumatology
Gregory McDermott, Ritu Gill, Staci Gagne, Suzanne Byrne, Weixing Huang, Xiaosong Wang, Lauren C. Prisco, Alessandra Zaccardelli, Lily W. Martin, Lucy Masto, Vanessa L. Kronzer, Nancy Shadick, Paul F. Dellaripa, Tracy J. Doyle, Jeffrey A. Sparks
Summary: The study investigates the demographic, lifestyle, and serologic risk factors associated with isolated rheumatoid arthritis (RA)-associated bronchiectasis (RA-BR) that is not caused by interstitial lung disease (ILD). The findings suggest that seropositivity, older age at RA diagnosis, and lower BMI at RA onset are associated with isolated bronchiectasis in RA that is not a result of ILD.
JOURNAL OF RHEUMATOLOGY
(2022)
Editorial Material
Rheumatology
Camilla R. L. Machado, Gary S. Firestein
Summary: Rheumatoid arthritis synovium contains fibroblast-like synoviocytes that are phenotypically and functionally heterogeneous. Advanced analyses have identified at least four distinct cell states, which are determined by the cells' location in the synovium, epigenetic imprinting, and the influence of microenvironment mediators.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Codrina Ancuta, Rodica Chirieac, Eugen Ancuta, Oana Tanculescu, Sorina Mihaela Solomon, Ana Maria Fatu, Adrian Doloca, Cristina Iordache
Summary: This study showed that tocilizumab can significantly improve gingival conditions in patients with periodontal disease in the short term, with notable impact on bleeding on probing and probing pocket depth. Additionally, significant correlations were found between periodontal status, disease activity, and serologic biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Yunju Jeong, JooYeon Jhun, Seon-Yeong Lee, Hyun Sik Na, JeongWon Choi, Keun-Hyung Cho, Seung Yoon Lee, A. Ram Lee, Sang-Jun Park, Hyun Ju You, Ji-Won Kim, Myeong Soo Park, Bin Kwon, Mi-La Cho, Geun Eog Ji, Sung-Hwan Park
Summary: The study found significant differences in gut microbiota composition in patients with different RF levels, and B. longum RAPO may alleviate RA by inhibiting the production of IL-17, reducing inflammation, bone damage, and cartilage damage. Further investigation is needed to evaluate the safety and efficacy of B. longum RAPO in patients with RA and other autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Yu-Wei Wang, Jia-Feng Chen, Chi-Hua Ko, Tien-Tsai Cheng, Wen-Chan Chiu, Shan-Fu Yu, Chung-Yuan Hsu, Ying-Chou Chen
Summary: This study aimed to evaluate the factors predicting subclinical inflammation of wrist joints in patients with rheumatoid arthritis (RA) who were in clinical remission or low disease activity. Gray scale and power Doppler ultrasound were performed to assess synovitis, comorbidities, and the use of disease-modifying anti-rheumatic drugs (DMARDs). A multivariable forward logistic regression analysis revealed that male sex and smoking were positively associated with inflammation, while age, alcohol consumption, and the use of methotrexate, glucocorticoids, or biological therapy were negatively associated with inflammation. The use of biological agents reduced the risk of inflammation by 40.9%.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Rheumatology
Xanthe M. E. Matthijssen, Ellis Niemantsverdriet, Saskia Le Cessie, Annette H. M. Van der Helm-van Mil
Summary: This study found that the decrease of inflammatory features usually occurs simultaneously in patients with RA and undifferentiated arthritis, including in ACPA subgroups, but synovitis decrease typically precedes tenosynovitis decrease. Additionally, in ACPA-positive patients, synovitis decrease occurs before osteitis decrease.
Article
Nutrition & Dietetics
Christina Heidt, Joern Pons-Kuehnemann, Ulrike Kaemmerer, Thorsten Marquardt, Monika Reuss-Borst
Summary: This study investigated the effect of medium-chain triglycerides (MCTs) on disease activity in rheumatoid arthritis (RA) patients. The preliminary results showed a significant reduction in disease activity index (SDAI) and an increase in beta-hydroxybutyrate (BHB) levels in RA patients supplemented with MCT.
Article
Rheumatology
Jorge Rojas-Serrano, Mayra Mejia, Pedro A. Rivera-Matias, Denisse Herrera-Bringas, Diana Perez-Roman, Renzo Perez-Dorame, Heidegger Mateos-Toledo
Summary: This study suggests a correlation between higher RA disease activity and worse prognosis in RA-ILD patients. Further cohort studies and clinical trials are needed to evaluate the hypothesis that high disease activity is associated with worse survival in RA-ILD patients.
CLINICAL RHEUMATOLOGY
(2022)
Article
Food Science & Technology
Farzana Athirah Abdul Latif, Wan Syamimee Wan Ghazali, Siti Mardhiana Mohamad, Lai Kuan Lee
Summary: This study investigated the effects of 12 weeks high fiber multigrain supplementation on disease activity scores, circulating inflammatory and oxidative stress biomarkers in patients with Rheumatoid Arthritis (RA). The results showed significant improvement in disease activity scores, morning stiffness, joint and pain scales in the multigrain supplementation group. Additionally, the supplementation group also exhibited reduced circulating inflammatory biomarkers, improved oxidative stress indices and antioxidant status.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Medicine, General & Internal
Hideaki Yamakawa, Takashi Ogura, Hideto Kameda, Tomoo Kishaba, Tae Iwasawa, Tamiko Takemura, Kazuyoshi Kuwano
Summary: RA is a common autoimmune arthritis, with ILD being the most important comorbidity. The acute form should be promptly treated with high-dose corticosteroids and antimicrobial agents, while the chronic form requires stabilization of RA followed by ILD management. Identification of UIP pattern and consideration of anti-fibrotic agents are crucial in patient care.
JOURNAL OF CLINICAL MEDICINE
(2021)
