Review
Biochemistry & Molecular Biology
Raj Kumar Mongre, Chandra Bhushan Mishra, Arvind Kumar Shukla, Amresh Prakash, Samil Jung, Md Ashraf-Uz-Zaman, Myeong-Sok Lee
Summary: This article discusses the crucial role of receptor tyrosine kinases in cancer therapy and the efficacy of TKIs as targeted therapy for various cancers. It emphasizes the signaling transduction and therapeutic effects of TKIs, as well as their applications in clinical trials and preclinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xinran Li, Amy Y. T. Lau, Angel S. N. Ng, Abdullah Aldehaiman, Yuan Zhou, Patrick K. S. Ng, Stefan T. Arold, Lydia W. T. Cheung
Summary: The study demonstrates that driver mutations in p85α can activate multiple kinase pathways and promote malignant growth of cancer cells. These mutations increase HER3 protein levels by inhibiting HER3 ubiquitination and degradation, leading to its heterodimerization with EGFR, HER2, and c-Met, as well as the allosteric activation of these dimerized partners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Analytical
Juan Gao, Jingyi Jian, Zhengjin Jiang, Ann Van Schepdael
Summary: Tyrosine kinases have been extensively studied as drug targets due to their regulation of cellular processes. The deregulation of tyrosine kinases plays a key role in the pathophysiology of various diseases. Several techniques, including traditional binding assays and high-throughput screening methods, have been developed to discover new tyrosine kinase inhibitors. This review provides insights into the different assay methods for the exploration of novel tyrosine kinase inhibitors.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Oncology
Lucia Gandullo-Sanchez, Alberto Ocana, Atanasio Pandiella
Summary: HER3 protein is closely associated with the development of various tumors, and targeting HER3 has therapeutic relevance in promoting cell proliferation. Different types of agents targeting HER3 have been developed, including antibodies, aptamers, and vaccines. This article reviews the preclinical and clinical development of drugs targeting HER3.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Cell Biology
Li Chen, Xiangyi Kong, Yi Fang, Shishir Paunikar, Xiangyu Wang, James A. L. Brown, Emer Bourke, Xingrui Li, Jing Wang
Summary: Discoidin domain receptor tyrosine kinases (DDRs) are a type of receptor tyrosine kinases associated with various diseases, widely expressed in different cell types and involved in signaling pathways, closely related to the development and progression of solid tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Alida Besch, William M. Marsiglia, Moosa Mohammadi, Yingkai Zhang, Nathaniel J. Traaseth
Summary: Many human cancers are treated with small molecule inhibitors that target the kinase domain of receptor tyrosine kinases. Long-term treatment often leads to drug resistance mutations at the gatekeeper residue, increasing the aggressiveness of the cancer. However, the mechanism of gain-of-function by gatekeeper mutations is poorly understood.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Bihui Cao, Manting Liu, Lu Wang, Kangshun Zhu, Mingyue Cai, Xiaopei Chen, Yunfei Feng, Shuo Yang, Shengyu Fu, Cheng Zhi, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Xin Yang, Ming Zhao, Qingde Wu, Linfeng Xu, Lili Yang, Hui Lian, Qi Zhao, Zhenfeng Zhang
Summary: The complex immunosuppressive tumor microenvironment and lack of tumor-specific targets hinder the application of CAR T cell therapy in solid tumors. AXL, highly expressed in NSCLC but not in normal tissues, might be a target for CAR T cell therapy. Combining microwave ablation and AXL-CAR T cells shows superior antitumor efficacy.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Akanksha Gandhi, Ralf Oelmueller
Summary: Plants rely on membrane-bound receptor-like kinases (RLKs) to perceive and respond to stress signals. While they play a crucial role in growth, reproduction, hormone perception, and defense responses against biotic stresses, their involvement in abiotic stress responses is not well-documented. This review summarizes the sub-classes of RLKs based on their domain structure and discusses their specific role in abiotic stress adaptation. The importance of RLKs in abiotic stress responses and their potential for engineering stress-tolerant crop varieties are highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Wei-Qing Shao, Wen-Wei Zhu, Meng-Jun Luo, Ming-Hao Fan, Qin Li, Sheng-Hao Wang, Zhi-Fei Lin, Jing Zhao, Yan Zheng, Qiong-Zhu Dong, Lu Lu, Hu-Liang Jia, Ju-Bo Zhang, Ming Lu, Jin-Hong Chen, Lun-Xiu Qin
Summary: This study reveals that cholesterol suppresses the autophagic degradation of RTKs in a GOLM1-dependent manner, and lowering cholesterol by statins can enhance the efficacy of multiple tyrosine kinase inhibitors in HCC.
Review
Endocrinology & Metabolism
Rong Tang, Wallace Y. Langdon, Jian Zhang
Summary: Receptor tyrosine kinases (RTKs) are transmembrane receptors involved in various cellular processes. The negative regulation of RTKs by the Cbl family proteins has attracted interest for potential therapeutic applications in diseases including cancer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
William McCoull, Scott Boyd, Martin R. Brown, Muireann Coen, Olga Collingwood, Nichola L. Davies, Ann Doherty, Gary Fairley, Kristin Goldberg, Elizabeth Hardaker, Guang He, Edward J. Hennessy, Philip Hopcroft, George Hodgson, Anne Jackson, Xiefeng Jiang, Ankur Karmokar, Anne-Laure Laine, Nicola Lindsay, Yumeng Mao, Roshini Markandu, Lindsay McMurray, Neville McLean, Lorraine Mooney, Helen Musgrove, J. Willem M. Nissink, Alexander Pflug, Venkatesh Pilla Reddy, Philip B. Rawlins, Emma Rivers, Marianne Schimpl, Graham F. Smith, Sharon Tentarelli, Jon Travers, Robert Troup, Josephine Walton, Cheng Wang, Stephen Wilkinson, Beth Williamson, Jon Winter-Holt, Dejian Yang, Yuting Zheng, Qianxiu Zhu, Paul D. Smith
Summary: Inhibition of Mer and Axl kinases has been suggested as a potential way to enhance immuno-oncology therapeutics by restoring the innate immune response in the tumor microenvironment. Highly selective dual Mer/Axl kinase inhibitors were optimized from hits from a DNA-encoded library screen, showing in vivo efficacy and target engagement in Mer- and Axl-dependent efficacy models. Additionally, in vivo efficacy was observed in a preclinical MC38 immuno-oncology model in combination with anti-PD1 antibodies and ionizing radiation.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Zhonghua Shi, Xiaoyan Li, Mengxing Wei, Peiyao Chen, Ting Zhang, Xiufeng Ling, Junqiang Zhang, Chun Zhao, Fuqiang Wang, Gaolin Liang
Summary: The development of a new hydrogel Gel Y + Inh provides a smart strategy to delay ovarian aging by releasing Inh that moderately inhibits mTOR activity. Experimental results in oocytes and zygotes show improvement in meiotic maturation and early embryonic development with Gel Y + Inh treatment.
Review
Biochemistry & Molecular Biology
Supratim Mandal, Shrabasti Bandyopadhyay, Komal Tyagi, Adhiraj Roy
Summary: Phosphoinositide metabolism is a critical intracellular signaling system that regulates various biological functions, and PLCγ1, as a member of the PLC family, plays a crucial role in tumorigenesis by modulating cell survival, migration, invasion, and angiogenesis. The aberrant expression and regulation of PLCγ1 are linked to a range of deadly human cancers, highlighting its significance as a potential therapeutic target in cancer research. Further studies are needed to fully understand PLCγ1's precise role in carcinogenesis and its potential as a novel treatment target.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Anatomy & Morphology
Jeremiah P. C. Stinson, Cooper A. Brett, Julianne B. Carroll, Mark L. Gabriele
Summary: Guidance errors and unrefined neural map configurations may be linked to certain neurodevelopmental conditions, including autism spectrum disorders. The lateral cortex of the inferior colliculus (LCIC) integrates information from multiple levels and modalities, and Eph-ephrin signaling mechanisms may play a significant role in ordering behaviorally significant multisensory midbrain networks.
FRONTIERS IN NEUROANATOMY
(2021)
Review
Cell Biology
Trishna Saha, Hava Gil-Henn
Summary: Non-receptor tyrosine kinases (NRTKs) play a crucial role in regulating intracellular signaling and are associated with various diseases, including cancer metastasis. Understanding how NRTKs control invadopodia formation can potentially lead to new treatments for cancer metastasis.