4.7 Article

Approximate Maximum Parsimony and Ancestral Maximum Likelihood

Publisher

IEEE COMPUTER SOC
DOI: 10.1109/TCBB.2008.13

Keywords

Phylogenetic reconstruction; ancestral maximum likelihood; maximum parsimony; Steiner trees; approximation algorithms

Funding

  1. Israel Science Foundation
  2. USA-Israel BSF
  3. Hermann Minkowski Minerva Center for Geometry

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We explore the maximum parsimony (MP) and ancestral maximum likelihood (AML) criteria in phylogenetic tree reconstruction. Both problems are NP-hard, so we seek approximate solutions. We formulate the two problems as Steiner tree problems under appropriate distances. The gist of our approach is the succinct characterization of Steiner trees for a small number of leaves for the two distances. This enables the use of known Steiner tree approximation algorithms. The approach leads to a 16/9 approximation ratio for AML and asymptotically to a 1.55 approximation ratio for MP.

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